alpha-yohimbine-2778 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the alpha-yohimbine-2778 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACSBG2 acyl-CoA synthetase bubblegum family member 2
ADCY3 adenylate cyclase 3
ALCAM activated leukocyte cell adhesion molecule
ANGPTL2 angiopoietin-like 2
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
APP amyloid beta (A4) precursor protein
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ATF6B activating transcription factor 6 beta
BCL2L10 BCL2-like 10 (apoptosis facilitator)
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2
BTG2 BTG family, member 2
C21ORF2 chromosome 21 open reading frame 2
CABP1 calcium binding protein 1
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CGA glycoprotein hormones, alpha polypeptide
CLMN calmin (calponin-like, transmembrane)
CNTN1 contactin 1
CNTNAP2 contactin associated protein-like 2
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
DCAF15 DDB1 and CUL4 associated factor 15
DOK4 docking protein 4
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EGF epidermal growth factor
ENO3 enolase 3 (beta, muscle)
EPOR erythropoietin receptor
EXT1 exostosin glycosyltransferase 1
FRMD8 FERM domain containing 8
GATA4 GATA binding protein 4
GNG13 guanine nucleotide binding protein (G protein), gamma 13
GPER1 G protein-coupled estrogen receptor 1
GPR22 G protein-coupled receptor 22
GRIP2 glutamate receptor interacting protein 2
HIST1H3J histone cluster 1, H3j
HN1L hematological and neurological expressed 1-like
IL1B interleukin 1, beta
IL6ST interleukin 6 signal transducer
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KDM4C lysine (K)-specific demethylase 4C
KRT19P2 keratin 19 pseudogene 2
L3MBTL1 l(3)mbt-like 1 (Drosophila)
LAIR2 leukocyte-associated immunoglobulin-like receptor 2
LENEP lens epithelial protein
LGALS4 lectin, galactoside-binding, soluble, 4
LHFPL2 lipoma HMGIC fusion partner-like 2
LIMCH1 LIM and calponin homology domains 1
LMAN1 lectin, mannose-binding, 1
MAN2A2 mannosidase, alpha, class 2A, member 2
MAP4 microtubule-associated protein 4
MAPK10 mitogen-activated protein kinase 10
MAPK8 mitogen-activated protein kinase 8
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MON2 MON2 homolog (S. cerevisiae)
MTA2 metastasis associated 1 family, member 2
MZT2B mitotic spindle organizing protein 2B
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NLRX1 NLR family member X1
NPHP1 nephronophthisis 1 (juvenile)
OAZ3 ornithine decarboxylase antizyme 3
OR10J1 olfactory receptor, family 10, subfamily J, member 1
OVGP1 oviductal glycoprotein 1, 120kDa
PAX5 paired box 5
PCSK6 proprotein convertase subtilisin/kexin type 6
PHC3 polyhomeotic homolog 3 (Drosophila)
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
PRDM2 PR domain containing 2, with ZNF domain
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
RFXAP regulatory factor X-associated protein
RNF2 ring finger protein 2
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RTN2 reticulon 2
SCUBE3 signal peptide, CUB domain, EGF-like 3
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC35E2 solute carrier family 35, member E2
SMYD2 SET and MYND domain containing 2
SNTG1 syntrophin, gamma 1
SOX12 SRY (sex determining region Y)-box 12
SP1 Sp1 transcription factor
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
STK4 serine/threonine kinase 4
STMN1 stathmin 1
SULF1 sulfatase 1
SYNJ1 synaptojanin 1
TGM2 transglutaminase 2
TH tyrosine hydroxylase
TJAP1 tight junction associated protein 1 (peripheral)
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TYMS thymidylate synthetase
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
WDFY3 WD repeat and FYVE domain containing 3
WIPI2 WD repeat domain, phosphoinositide interacting 2
ZDHHC14 zinc finger, DHHC-type containing 14
ZNF442 zinc finger protein 442
ZNF710 zinc finger protein 710

decreased expression

Symbol Name
ACTL8 actin-like 8
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ADGRE5 adhesion G protein-coupled receptor E5
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
B9D2 B9 protein domain 2
BAGE B melanoma antigen
C2ORF27A chromosome 2 open reading frame 27A
C4ORF29 chromosome 4 open reading frame 29
CBX8 chromobox homolog 8
CCDC85C coiled-coil domain containing 85C
CCNO cyclin O
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CHKB choline kinase beta
CLCN6 chloride channel, voltage-sensitive 6
CORT cortistatin
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24
DNM1 dynamin 1
DVL1 dishevelled segment polarity protein 1
DYRK4 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
DZANK1 double zinc ribbon and ankyrin repeat domains 1
EFCAB2 EF-hand calcium binding domain 2
ERN2 endoplasmic reticulum to nucleus signaling 2
F3 coagulation factor III (thromboplastin, tissue factor)
FAM53B family with sequence similarity 53, member B
FOXN2 forkhead box N2
GINS4 GINS complex subunit 4 (Sld5 homolog)
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GPR143 G protein-coupled receptor 143
GSTA4 glutathione S-transferase alpha 4
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
GUSBP3 glucuronidase, beta pseudogene 3
HCFC1 host cell factor C1
HIRA histone cell cycle regulator
HIST1H2AL histone cluster 1, H2al
HMOX1 heme oxygenase 1
HOXC5 homeobox C5
IFT22 intraflagellar transport 22
IL22 interleukin 22
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa
KCTD7 potassium channel tetramerization domain containing 7
KLHL25 kelch-like family member 25
KRI1 KRI1 homolog (S. cerevisiae)
KRT86 keratin 86, type II
LHX6 LIM homeobox 6
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MYO1E myosin IE
N4BP3 NEDD4 binding protein 3
NCALD neurocalcin delta
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NIPAL2 NIPA-like domain containing 2
NPTX1 neuronal pentraxin I
NT5E 5'-nucleotidase, ecto (CD73)
ONECUT2 one cut homeobox 2
OSMR oncostatin M receptor
PC pyruvate carboxylase
PCDHA9 protocadherin alpha 9
PLA2G3 phospholipase A2, group III
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLD3 phospholipase D family, member 3
PP14571 uncharacterized LOC100130449
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2
PTK6 protein tyrosine kinase 6
PVRL3 poliovirus receptor-related 3
RAB8B RAB8B, member RAS oncogene family
RPAP1 RNA polymerase II associated protein 1
RPH3AL rabphilin 3A-like (without C2 domains)
SCN1B sodium channel, voltage gated, type I beta subunit
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC12A8 solute carrier family 12, member 8
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22
SLMO1 slowmo homolog 1 (Drosophila)
SOWAHC sosondowah ankyrin repeat domain family member C
SPINK5 serine peptidase inhibitor, Kazal type 5
STIM1 stromal interaction molecule 1
STON1 stonin 1
TAGLN transgelin
TCP10 t-complex 10
TICAM1 toll-like receptor adaptor molecule 1
TMSB15A thymosin beta 15a
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TTC30A tetratricopeptide repeat domain 30A
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
USP36 ubiquitin specific peptidase 36
VEZT vezatin, adherens junctions transmembrane protein
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZBTB22 zinc finger and BTB domain containing 22
ZBTB48 zinc finger and BTB domain containing 48
ZNF205 zinc finger protein 205
ZNF324 zinc finger protein 324
ZNF652 zinc finger protein 652
ZNF862 zinc finger protein 862
ZSCAN31 zinc finger and SCAN domain containing 31
ZW10 zw10 kinetochore protein