alpha-yohimbine-5800 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the alpha-yohimbine-5800 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AKAP5 A kinase (PRKA) anchor protein 5
ALPK1 alpha-kinase 1
AMPD1 adenosine monophosphate deaminase 1
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38
ARNT aryl hydrocarbon receptor nuclear translocator
ARTN artemin
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
BMP3 bone morphogenetic protein 3
C11ORF16 chromosome 11 open reading frame 16
C11ORF21 chromosome 11 open reading frame 21
C1ORF95 chromosome 1 open reading frame 95
CCDC57 coiled-coil domain containing 57
CD300A CD300a molecule
CD33 CD33 molecule
CD58 CD58 molecule
CD79B CD79b molecule, immunoglobulin-associated beta
CD93 CD93 molecule
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CFAP69 cilia and flagella associated protein 69
CHAT choline O-acetyltransferase
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
CPNE7 copine VII
CREBZF CREB/ATF bZIP transcription factor
CRYGD crystallin, gamma D
ELOVL5 ELOVL fatty acid elongase 5
ERC1 ELKS/RAB6-interacting/CAST family member 1
EXOSC1 exosome component 1
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2
FGF8 fibroblast growth factor 8 (androgen-induced)
FLRT2 fibronectin leucine rich transmembrane protein 2
FOXRED2 FAD-dependent oxidoreductase domain containing 2
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GSN gelsolin
GSN-AS1 GSN antisense RNA 1
GSTTP1 glutathione S-transferase theta pseudogene 1
HHAT hedgehog acyltransferase
HIST1H2BM histone cluster 1, H2bm
HKDC1 hexokinase domain containing 1
HOMER3 homer scaffolding protein 3
IFNA16 interferon, alpha 16
IGL immunoglobulin lambda locus
IRF2BP1 interferon regulatory factor 2 binding protein 1
ITGA7 integrin, alpha 7
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KLHL1 kelch-like family member 1
LARGE like-glycosyltransferase
LOX lysyl oxidase
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
LY9 lymphocyte antigen 9
MAGEA1 melanoma antigen family A1
MAP3K7CL MAP3K7 C-terminal like
MAPK14 mitogen-activated protein kinase 14
MBNL2 muscleblind-like splicing regulator 2
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MMP27 matrix metallopeptidase 27
MTMR3 myotubularin related protein 3
MYCNOS MYCN opposite strand
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NFX1 nuclear transcription factor, X-box binding 1
NME5 NME/NM23 family member 5
OAZ3 ornithine decarboxylase antizyme 3
OR10H1 olfactory receptor, family 10, subfamily H, member 1
PAIP2B poly(A) binding protein interacting protein 2B
PDE4D phosphodiesterase 4D, cAMP-specific
PKNOX1 PBX/knotted 1 homeobox 1
PRKCA protein kinase C, alpha
PRKG1 protein kinase, cGMP-dependent, type I
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTPRU protein tyrosine phosphatase, receptor type, U
PVR poliovirus receptor
RAD51 RAD51 recombinase
RBPMS RNA binding protein with multiple splicing
RCN3 reticulocalbin 3, EF-hand calcium binding domain
RGS5 regulator of G-protein signaling 5
SEC14L4 SEC14-like 4 (S. cerevisiae)
SHOX2 short stature homeobox 2
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SPP1 secreted phosphoprotein 1
TBC1D30 TBC1 domain family, member 30
TGM4 transglutaminase 4
TIMELESS timeless circadian clock
TMEM180 transmembrane protein 180
TMF1 TATA element modulatory factor 1
TMPRSS2 transmembrane protease, serine 2
TRAC T cell receptor alpha constant
TRPC5 transient receptor potential cation channel, subfamily C, member 5
TSHR thyroid stimulating hormone receptor
UBE2I ubiquitin-conjugating enzyme E2I
UCN urocortin
WFDC2 WAP four-disulfide core domain 2
ZC2HC1C zinc finger, C2HC-type containing 1C
ZMYND8 zinc finger, MYND-type containing 8
ZNF224 zinc finger protein 224

decreased expression

Symbol Name
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
ARHGAP24 Rho GTPase activating protein 24
ART1 ADP-ribosyltransferase 1
BCL2L10 BCL2-like 10 (apoptosis facilitator)
BET1L Bet1 golgi vesicular membrane trafficking protein-like
BRAF B-Raf proto-oncogene, serine/threonine kinase
C17ORF53 chromosome 17 open reading frame 53
C1QTNF3 C1q and tumor necrosis factor related protein 3
C1R complement component 1, r subcomponent
C1RL complement component 1, r subcomponent-like
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CCDC71 coiled-coil domain containing 71
CCNO cyclin O
CDKL3 cyclin-dependent kinase-like 3
CEP295 centrosomal protein 295kDa
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
COBL cordon-bleu WH2 repeat protein
CORO1A coronin, actin binding protein, 1A
CORT cortistatin
CPEB1 cytoplasmic polyadenylation element binding protein 1
CTSF cathepsin F
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DDN dendrin
DMTN dematin actin binding protein
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
ERCC4 excision repair cross-complementation group 4
ERMAP erythroblast membrane-associated protein (Scianna blood group)
EYA4 EYA transcriptional coactivator and phosphatase 4
FAM63B family with sequence similarity 63, member B
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GLS2 glutaminase 2 (liver, mitochondrial)
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPR27 G protein-coupled receptor 27
GRTP1 growth hormone regulated TBC protein 1
HIST1H1D histone cluster 1, H1d
HIST1H1T histone cluster 1, H1t
HIST1H3B histone cluster 1, H3b
HIST1H4D histone cluster 1, H4d
HIST1H4E histone cluster 1, H4e
HOXA7 homeobox A7
HOXC5 homeobox C5
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
IL11RA interleukin 11 receptor, alpha
IL4R interleukin 4 receptor
ITGA10 integrin, alpha 10
KRT86 keratin 86, type II
KRT9 keratin 9, type I
LAMC3 laminin, gamma 3
LOC100287590 uncharacterized LOC100287590
LOC257152 uncharacterized LOC257152
LOC729164 hCG1732469
LRRK1 leucine-rich repeat kinase 1
MAST3 microtubule associated serine/threonine kinase 3
MMP3 matrix metallopeptidase 3
MVD mevalonate (diphospho) decarboxylase
MYL5 myosin, light chain 5, regulatory
NABP1 nucleic acid binding protein 1
NPY1R neuropeptide Y receptor Y1
NTF3 neurotrophin 3
ODF2 outer dense fiber of sperm tails 2
OR1D2 olfactory receptor, family 1, subfamily D, member 2
OR3A3 olfactory receptor, family 3, subfamily A, member 3
PAN2 PAN2 poly(A) specific ribonuclease subunit
PCDHGB5 protocadherin gamma subfamily B, 5
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
POMT2 protein-O-mannosyltransferase 2
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTPRH protein tyrosine phosphatase, receptor type, H
RETN resistin
RHOBTB2 Rho-related BTB domain containing 2
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RPL13P5 ribosomal protein L13 pseudogene 5
RUNX1-IT1 RUNX1 intronic transcript 1
RUSC2 RUN and SH3 domain containing 2
SCG2 secretogranin II
SEC14L2 SEC14-like 2 (S. cerevisiae)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7
SP1 Sp1 transcription factor
SREK1IP1 SREK1-interacting protein 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STK16 serine/threonine kinase 16
TMCC2 transmembrane and coiled-coil domain family 2
TMEM212 transmembrane protein 212
TSKU tsukushi, small leucine rich proteoglycan
TTC30A tetratricopeptide repeat domain 30A
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
WDR62 WD repeat domain 62
ZNF230 zinc finger protein 230
ZNF37BP zinc finger protein 37B, pseudogene
ZNF510 zinc finger protein 510
ZNF667 zinc finger protein 667
ZNF76 zinc finger protein 76
ZNF862 zinc finger protein 862