alprenolol-7141 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the alprenolol-7141 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ABI2 abl-interactor 2
AP4S1 adaptor-related protein complex 4, sigma 1 subunit
AQR aquarius intron-binding spliceosomal factor
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
ARNT aryl hydrocarbon receptor nuclear translocator
ATF7IP2 activating transcription factor 7 interacting protein 2
AUH AU RNA binding protein/enoyl-CoA hydratase
BAHCC1 BAH domain and coiled-coil containing 1
BAIAP2 BAI1-associated protein 2
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
C19ORF54 chromosome 19 open reading frame 54
C7ORF43 chromosome 7 open reading frame 43
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CCNO cyclin O
CDH7 cadherin 7, type 2
CDIP1 cell death-inducing p53 target 1
CREB3L1 cAMP responsive element binding protein 3-like 1
DENND3 DENN/MADD domain containing 3
DSPP dentin sialophosphoprotein
EDRF1 erythroid differentiation regulatory factor 1
ERCC1 excision repair cross-complementation group 1
ERN2 endoplasmic reticulum to nucleus signaling 2
ESRRA estrogen-related receptor alpha
FA2H fatty acid 2-hydroxylase
FGF5 fibroblast growth factor 5
FOXJ3 forkhead box J3
FZD7 frizzled class receptor 7
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
GPALPP1 GPALPP motifs containing 1
GPATCH2L G patch domain containing 2-like
GPR137 G protein-coupled receptor 137
H2AFX H2A histone family, member X
HIST1H2AJ histone cluster 1, H2aj
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IRF2BP1 interferon regulatory factor 2 binding protein 1
JUND jun D proto-oncogene
KDM5C lysine (K)-specific demethylase 5C
KIAA1549L KIAA1549-like
KLF4 Kruppel-like factor 4 (gut)
KLHL20 kelch-like family member 20
LNPEP leucyl/cystinyl aminopeptidase
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MARS methionyl-tRNA synthetase
MBL1P mannose-binding lectin (protein A) 1, pseudogene
METTL7A methyltransferase like 7A
MMRN2 multimerin 2
MON2 MON2 homolog (S. cerevisiae)
MRPS14 mitochondrial ribosomal protein S14
MXD4 MAX dimerization protein 4
NF2 neurofibromin 2 (merlin)
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NUFIP1 nuclear fragile X mental retardation protein interacting protein 1
OPTN optineurin
PAX9 paired box 9
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PDE8B phosphodiesterase 8B
PDGFB platelet-derived growth factor beta polypeptide
PDLIM5 PDZ and LIM domain 5
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
PGPEP1 pyroglutamyl-peptidase I
PIGO phosphatidylinositol glycan anchor biosynthesis, class O
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6
PNPLA4 patatin-like phospholipase domain containing 4
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKCE protein kinase C, epsilon
RAB11FIP3 RAB11 family interacting protein 3 (class II)
RAB27B RAB27B, member RAS oncogene family
RABEP2 rabaptin, RAB GTPase binding effector protein 2
SCEL sciellin
SCG5 secretogranin V
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SGSM3 small G protein signaling modulator 3
SIPA1L3 signal-induced proliferation-associated 1 like 3
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2
SLC38A7 solute carrier family 38, member 7
SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa
SPRYD7 SPRY domain containing 7
TBC1D17 TBC1 domain family, member 17
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
THOC5 THO complex 5
TPP1 tripeptidyl peptidase I
TPRA1 transmembrane protein, adipocyte asscociated 1
TWISTNB TWIST neighbor
USP34 ubiquitin specific peptidase 34
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae)
WDTC1 WD and tetratricopeptide repeats 1
ZC3H12A zinc finger CCCH-type containing 12A
ZNF253 zinc finger protein 253
ZNF467 zinc finger protein 467
ZNF510 zinc finger protein 510
ZNF701 zinc finger protein 701

decreased expression

Symbol Name
ACTR3B ARP3 actin-related protein 3 homolog B (yeast)
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ANG angiogenin, ribonuclease, RNase A family, 5
ANKZF1 ankyrin repeat and zinc finger domain containing 1
ANXA10 annexin A10
APLP1 amyloid beta (A4) precursor-like protein 1
ARSJ arylsulfatase family, member J
BTBD2 BTB (POZ) domain containing 2
C19ORF40 chromosome 19 open reading frame 40
C9ORF91 chromosome 9 open reading frame 91
CAPN5 calpain 5
CCDC68 coiled-coil domain containing 68
CCRL2 chemokine (C-C motif) receptor-like 2
CFAP44 cilia and flagella associated protein 44
COQ4 coenzyme Q4
CTAGE9 CTAGE family, member 9
CXCL2 chemokine (C-X-C motif) ligand 2
DDIT4 DNA-damage-inducible transcript 4
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
EAF2 ELL associated factor 2
EDIL3 EGF-like repeats and discoidin I-like domains 3
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3
ERCC5 excision repair cross-complementation group 5
EYA4 EYA transcriptional coactivator and phosphatase 4
FER fer (fps/fes related) tyrosine kinase
FZD3 frizzled class receptor 3
GLTSCR1 glioma tumor suppressor candidate region gene 1
GMIP GEM interacting protein
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GPRASP1 G protein-coupled receptor associated sorting protein 1
HIST1H2AI histone cluster 1, H2ai
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1
HS1BP3 HCLS1 binding protein 3
IL10RB interleukin 10 receptor, beta
INCENP inner centromere protein antigens 135/155kDa
IRF2 interferon regulatory factor 2
IRF9 interferon regulatory factor 9
KATNA1 katanin p60 (ATPase containing) subunit A 1
KCTD15 potassium channel tetramerization domain containing 15
KIAA0556 KIAA0556
KIAA0753 KIAA0753
KLC2 kinesin light chain 2
MAN2B2 mannosidase, alpha, class 2B, member 2
MAST3 microtubule associated serine/threonine kinase 3
MB myoglobin
MOCOS molybdenum cofactor sulfurase
MON1B MON1 secretory trafficking family member B
NARFL nuclear prelamin A recognition factor-like
NCS1 neuronal calcium sensor 1
NOL6 nucleolar protein 6 (RNA-associated)
NPDC1 neural proliferation, differentiation and control, 1
OLFML2A olfactomedin-like 2A
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PECR peroxisomal trans-2-enoyl-CoA reductase
PEX26 peroxisomal biogenesis factor 26
PHKG2 phosphorylase kinase, gamma 2 (testis)
PLA2G15 phospholipase A2, group XV
PLD3 phospholipase D family, member 3
POLM polymerase (DNA directed), mu
PPT2 palmitoyl-protein thioesterase 2
PRMT7 protein arginine methyltransferase 7
RAB3A RAB3A, member RAS oncogene family
RNF126P1 ring finger protein 126 pseudogene 1
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SAMD9 sterile alpha motif domain containing 9
SESN1 sestrin 1
SIPA1 signal-induced proliferation-associated 1
SIRT2 sirtuin 2
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
SNIP1 Smad nuclear interacting protein 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TBX19 T-box 19
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
THBS3 thrombospondin 3
TM7SF2 transmembrane 7 superfamily member 2
TMEM104 transmembrane protein 104
TMEM209 transmembrane protein 209
TTLL7 tubulin tyrosine ligase-like family member 7
TUBA3D tubulin, alpha 3d
UBL4A ubiquitin-like 4A
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
ZDHHC14 zinc finger, DHHC-type containing 14
ZFP36 ZFP36 ring finger protein
ZFP69B ZFP69 zinc finger protein B
ZNF134 zinc finger protein 134
ZNF180 zinc finger protein 180
ZNF282 zinc finger protein 282
ZNF574 zinc finger protein 574
ZNF623 zinc finger protein 623
ZNF770 zinc finger protein 770
ZNF804A zinc finger protein 804A
ZXDC ZXD family zinc finger C