altered susceptibility to infection induced morbidity/mortality Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description differences from the expected moribund state caused by a pathogenic invasion or from components of or toxins produced by pathogens (Mammalian Phenotype Ontology, MP_0009785)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0009785
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Genes

148 gene mutations causing the altered susceptibility to infection induced morbidity/mortality phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADGRE5 adhesion G protein-coupled receptor E5
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AICDA activation-induced cytidine deaminase
AIM2 absent in melanoma 2
ANK1 ankyrin 1, erythrocytic
ANTXR2 anthrax toxin receptor 2
APCS amyloid P component, serum
AQP4 aquaporin 4
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
B2M beta-2-microglobulin
BATF2 basic leucine zipper transcription factor, ATF-like 2
BTK Bruton agammaglobulinemia tyrosine kinase
C3 complement component 3
C4A complement component 4A (Rodgers blood group)
CAMP cathelicidin antimicrobial peptide
CASP12 caspase 12 (gene/pseudogene)
CAV1 caveolin 1, caveolae protein, 22kDa
CCL13 chemokine (C-C motif) ligand 13
CCR1 chemokine (C-C motif) receptor 1
CCR2 chemokine (C-C motif) receptor 2
CD14 CD14 molecule
CD1D CD1d molecule
CD200R1 CD200 receptor 1
CD274 CD274 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD47 CD47 molecule
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CLEC4D C-type lectin domain family 4, member D
CLEC6A C-type lectin domain family 6, member A
CR2 complement component (3d/Epstein Barr virus) receptor 2
CTSG cathepsin G
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL6 chemokine (C-X-C motif) ligand 6
CXCR2 chemokine (C-X-C motif) receptor 2
CXCR3 chemokine (C-X-C motif) receptor 3
CXCR4 chemokine (C-X-C motif) receptor 4
CYLD cylindromatosis (turban tumor syndrome)
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58
DUSP1 dual specificity phosphatase 1
ELANE elastase, neutrophil expressed
FBXO7 F-box protein 7
FCMR Fc fragment of IgM receptor
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FGL2 fibrinogen-like 2
FLT3 fms-related tyrosine kinase 3
FOXN1 forkhead box N1
FPR1 formyl peptide receptor 1
GBP2 guanylate binding protein 2, interferon-inducible
GBP3 guanylate binding protein 3
GPR15 G protein-coupled receptor 15
GUCY2C guanylate cyclase 2C
HAMP hepcidin antimicrobial peptide
HAVCR2 hepatitis A virus cellular receptor 2
HMOX1 heme oxygenase 1
ICAM1 intercellular adhesion molecule 1
IFIT1B interferon-induced protein with tetratricopeptide repeats 1B
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFITM3 interferon induced transmembrane protein 3
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IL12B interleukin 12B
IL13 interleukin 13
IL15 interleukin 15
IL17A interleukin 17A
IL17RE interleukin 17 receptor E
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL22 interleukin 22
IL23A interleukin 23, alpha subunit p19
IL27 interleukin 27
IL34 interleukin 34
IL4 interleukin 4
IL6 interleukin 6
IL6R interleukin 6 receptor
IRF1 interferon regulatory factor 1
JAK3 Janus kinase 3
JCHAIN joining chain of multimeric IgA and IgM
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8
KHSRP KH-type splicing regulatory protein
KLRK1 killer cell lectin-like receptor subfamily K, member 1
LIF leukemia inhibitory factor
LTA lymphotoxin alpha
LTB lymphotoxin beta (TNF superfamily, member 3)
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MAVS mitochondrial antiviral signaling protein
MB21D1 Mab-21 domain containing 1
MMP9 matrix metallopeptidase 9
MRC1 mannose receptor, C type 1
MSR1 macrophage scavenger receptor 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
MX1 MX dynamin-like GTPase 1
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
MYD88 myeloid differentiation primary response 88
NCOA3 nuclear receptor coactivator 3
NCR1 natural cytotoxicity triggering receptor 1
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NOD2 nucleotide-binding oligomerization domain containing 2
NOS3 nitric oxide synthase 3 (endothelial cell)
OASL 2'-5'-oligoadenylate synthetase-like
OTUD7B OTU deubiquitinase 7B
PELI3 pellino E3 ubiquitin protein ligase family member 3
PGLYRP1 peptidoglycan recognition protein 1
PGLYRP2 peptidoglycan recognition protein 2
PIAS1 protein inhibitor of activated STAT, 1
PILRA paired immunoglobin-like type 2 receptor alpha
PILRB paired immunoglobin-like type 2 receptor beta
PKLR pyruvate kinase, liver and RBC
PRF1 perforin 1 (pore forming protein)
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RAG2 recombination activating gene 2
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RORC RAR-related orphan receptor C
S100A9 S100 calcium binding protein A9
SARM1 sterile alpha and TIR motif containing 1
SDC1 syndecan 1
SELK selenoprotein K
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SFN stratifin
SLAMF6 SLAM family member 6
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SOCS1 suppressor of cytokine signaling 1
SPP1 secreted phosphoprotein 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT2 signal transducer and activator of transcription 2, 113kDa
STAT4 signal transducer and activator of transcription 4
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TBK1 TANK-binding kinase 1
TERF2IP telomeric repeat binding factor 2, interacting protein
TICAM1 toll-like receptor adaptor molecule 1
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TMEM173 transmembrane protein 173
TNF tumor necrosis factor
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TREX1 three prime repair exonuclease 1
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TRPV2 transient receptor potential cation channel, subfamily V, member 2
TYK2 tyrosine kinase 2
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
USP18 ubiquitin specific peptidase 18
USP21 ubiquitin specific peptidase 21
VTCN1 V-set domain containing T cell activation inhibitor 1