altering Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
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Genes

443 genes co-occuring with the biological term altering in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ABCD4 ATP-binding cassette, sub-family D (ALD), member 4
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACO1 aconitase 1, soluble
ACOT12 acyl-CoA thioesterase 12
ACTN1 actinin, alpha 1
ACTN4 actinin, alpha 4
ADAM9 ADAM metallopeptidase domain 9
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADAMTS18 ADAM metallopeptidase with thrombospondin type 1 motif, 18
ADIPOQ adiponectin, C1Q and collagen domain containing
ADRA2A adrenoceptor alpha 2A
ADRB2 adrenoceptor beta 2, surface
AGA aspartylglucosaminidase
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
AGTR1 angiotensin II receptor, type 1
AHCY adenosylhomocysteinase
AICDA activation-induced cytidine deaminase
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1
ALOX15 arachidonate 15-lipoxygenase
AMER2 APC membrane recruitment protein 2
APC adenomatous polyposis coli
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APOA1 apolipoprotein A-I
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARRB2 arrestin, beta 2
ASIC1 acid sensing (proton gated) ion channel 1
ATG5 autophagy related 5
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1
AXIN2 axin 2
B3GNT8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8
BAX BCL2-associated X protein
BCAR1 breast cancer anti-estrogen resistance 1
BCAR3 breast cancer anti-estrogen resistance 3
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BDNF brain-derived neurotrophic factor
BEST1 bestrophin 1
BLK BLK proto-oncogene, Src family tyrosine kinase
BMP4 bone morphogenetic protein 4
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BRWD3 bromodomain and WD repeat domain containing 3
BSG basigin (Ok blood group)
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASR calcium-sensing receptor
CAT catalase
CAV1 caveolin 1, caveolae protein, 22kDa
CBX1 chromobox homolog 1
CD14 CD14 molecule
CD44 CD44 molecule (Indian blood group)
CDC42 cell division cycle 42
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK2 cyclin-dependent kinase 2
CDK9 cyclin-dependent kinase 9
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDO1 cysteine dioxygenase type 1
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CFL1 cofilin 1 (non-muscle)
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHAT choline O-acetyltransferase
CHGA chromogranin A
CLCNKB chloride channel, voltage-sensitive Kb
CLDN11 claudin 11
CLDN2 claudin 2
CLIC4 chloride intracellular channel 4
CPB2 carboxypeptidase B2 (plasma)
CREB1 cAMP responsive element binding protein 1
CSF1 colony stimulating factor 1 (macrophage)
CSF1R colony stimulating factor 1 receptor
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CTGF connective tissue growth factor
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTSK cathepsin K
CTTN cortactin
CUL1 cullin 1
CXADR coxsackie virus and adenovirus receptor
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
CYBA cytochrome b-245, alpha polypeptide
CYCS cytochrome c, somatic
CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYSLTR2 cysteinyl leukotriene receptor 2
DAZAP1 DAZ associated protein 1
DCANP1 dendritic cell-associated nuclear protein
DEFB1 defensin, beta 1
DERL1 derlin 1
DIO2 deiodinase, iodothyronine, type II
DKC1 dyskeratosis congenita 1, dyskerin
DLL1 delta-like 1 (Drosophila)
DLX3 distal-less homeobox 3
DRD2 dopamine receptor D2
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
E2F1 E2F transcription factor 1
EEF2K eukaryotic elongation factor 2 kinase
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGFR epidermal growth factor receptor
EGR2 early growth response 2
EHF ets homologous factor
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
EIF4E eukaryotic translation initiation factor 4E
ELAVL4 ELAV like neuron-specific RNA binding protein 4
ENG endoglin
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ERCC2 excision repair cross-complementation group 2
ESR1 estrogen receptor 1
ESRRA estrogen-related receptor alpha
EYA1 EYA transcriptional coactivator and phosphatase 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F2 coagulation factor II (thrombin)
F2R coagulation factor II (thrombin) receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
F8 coagulation factor VIII, procoagulant component
F9 coagulation factor IX
FABP6 fatty acid binding protein 6, ileal
FADS1 fatty acid desaturase 1
FAS Fas cell surface death receptor
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
FGFR4 fibroblast growth factor receptor 4
FLT1 fms-related tyrosine kinase 1
FLT3 fms-related tyrosine kinase 3
FOXO1 forkhead box O1
FOXP2 forkhead box P2
FOXP3 forkhead box P3
FYN FYN proto-oncogene, Src family tyrosine kinase
FZD3 frizzled class receptor 3
GATA3 GATA binding protein 3
GATA4 GATA binding protein 4
GCK glucokinase (hexokinase 4)
GDNF glial cell derived neurotrophic factor
GHRL ghrelin/obestatin prepropeptide
GJA1 gap junction protein, alpha 1, 43kDa
GJA5 gap junction protein, alpha 5, 40kDa
GLA galactosidase, alpha
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPX1 glutathione peroxidase 1
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A
H19 H19, imprinted maternally expressed transcript (non-protein coding)
H2AFZ H2A histone family, member Z
HAX1 HCLS1 associated protein X-1
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HDAC3 histone deacetylase 3
HDAC6 histone deacetylase 6
HFE hemochromatosis
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HK2 hexokinase 2
HLA-A major histocompatibility complex, class I, A
HMGA2 high mobility group AT-hook 2
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HNF1A HNF1 homeobox A
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HRAS Harvey rat sarcoma viral oncogene homolog
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPB1 heat shock 27kDa protein 1
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
ICAM1 intercellular adhesion molecule 1
IFNB1 interferon, beta 1, fibroblast
IFNG interferon, gamma
IFT57 intraflagellar transport 57
IGF1R insulin-like growth factor 1 receptor
IGFBP1 insulin-like growth factor binding protein 1
IGFBP6 insulin-like growth factor binding protein 6
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IL1B interleukin 1, beta
IL21 interleukin 21
IL21R interleukin 21 receptor
IL3 interleukin 3
IL4 interleukin 4
IL4R interleukin 4 receptor
IL6 interleukin 6
ILF3 interleukin enhancer binding factor 3, 90kDa
INHBA inhibin, beta A
INSR insulin receptor
IRF1 interferon regulatory factor 1
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGA6 integrin, alpha 6
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITGB4 integrin, beta 4
ITGB8 integrin, beta 8
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
JAK2 Janus kinase 2
JUN jun proto-oncogene
KAT2B K(lysine) acetyltransferase 2B
KAT5 K(lysine) acetyltransferase 5
KAT7 K(lysine) acetyltransferase 7
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10
KCNMB4 potassium channel subfamily M regulatory beta subunit 4
KEAP1 kelch-like ECH-associated protein 1
KLF4 Kruppel-like factor 4 (gut)
LAMC2 laminin, gamma 2
LBP lipopolysaccharide binding protein
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2
LMNA lamin A/C
LMO4 LIM domain only 4
LPCAT1 lysophosphatidylcholine acyltransferase 1
LPL lipoprotein lipase
LRP1 low density lipoprotein receptor-related protein 1
LRRK2 leucine-rich repeat kinase 2
LY96 lymphocyte antigen 96
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MAPK14 mitogen-activated protein kinase 14
MAPRE1 microtubule-associated protein, RP/EB family, member 1
MAPT microtubule-associated protein tau
MBL2 mannose-binding lectin (protein C) 2, soluble
MBNL1 muscleblind-like splicing regulator 1
MCM7 minichromosome maintenance complex component 7
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MED23 mediator complex subunit 23
MEF2D myocyte enhancer factor 2D
MEIS1 Meis homeobox 1
MET MET proto-oncogene, receptor tyrosine kinase
MIR100 microRNA 100
MIR106B microRNA 106b
MIR132 microRNA 132
MIR138-2 microRNA 138-2
MIR146A microRNA 146a
MIR152 microRNA 152
MIR184 microRNA 184
MIR20A microRNA 20a
MIR21 microRNA 21
MIR221 microRNA 221
MIR222 microRNA 222
MIR25 microRNA 25
MIR26A1 microRNA 26a-1
MIR26A2 microRNA 26a-2
MIR375 microRNA 375
MIR378A microRNA 378a
MIR499A microRNA 499a
MIR502 microRNA 502
MIR99A microRNA 99a
MIRLET7C microRNA let-7c
MITF microphthalmia-associated transcription factor
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae)
MMP13 matrix metallopeptidase 13
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MSX2 msh homeobox 2
MT3 metallothionein 3
MTDH metadherin
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MUC4 mucin 4, cell surface associated
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
MYD88 myeloid differentiation primary response 88
MYH10 myosin, heavy chain 10, non-muscle
MYOD1 myogenic differentiation 1
NAE1 NEDD8 activating enzyme E1 subunit 1
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NCF2 neutrophil cytosolic factor 2
NCOA1 nuclear receptor coactivator 1
NCSTN nicastrin
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NEWENTRY Record to support submission of GeneRIFs for a gene not in Gene (human; man).
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKX3-1 NK3 homeobox 1
NLGN3 neuroligin 3
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH1 notch 1
NOTCH4 notch 4
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin)
NPSR1 neuropeptide S receptor 1
NR1D2 nuclear receptor subfamily 1, group D, member 2
NR1I2 nuclear receptor subfamily 1, group I, member 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR4A3 nuclear receptor subfamily 4, group A, member 3
NR5A1 nuclear receptor subfamily 5, group A, member 1
NRG1 neuregulin 1
NRTN neurturin
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
NUMB numb homolog (Drosophila)
NUP155 nucleoporin 155kDa
OLIG2 oligodendrocyte lineage transcription factor 2
ORM1 orosomucoid 1
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PF4 platelet factor 4
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PKD1 polycystic kidney disease 1 (autosomal dominant)
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PNP purine nucleoside phosphorylase
POU3F3 POU class 3 homeobox 3
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PRB2 proline-rich protein BstNI subfamily 2
PRDX6 peroxiredoxin 6
PRKCZ protein kinase C, zeta
PRL prolactin
PRNP prion protein
PRODH proline dehydrogenase (oxidase) 1
PRSS1 protease, serine, 1 (trypsin 1)
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2
PTCH1 patched 1
PTEN phosphatase and tensin homolog
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAD51 RAD51 recombinase
RBX1 ring-box 1, E3 ubiquitin protein ligase
RELN reelin
RER1 retention in endoplasmic reticulum sorting receptor 1
RET ret proto-oncogene
RGS7BP regulator of G-protein signaling 7 binding protein
RORC RAR-related orphan receptor C
RP2 retinitis pigmentosa 2 (X-linked recessive)
RPE ribulose-5-phosphate-3-epimerase
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2
RPTOR regulatory associated protein of MTOR, complex 1
S100A4 S100 calcium binding protein A4
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCN1A sodium channel, voltage gated, type I alpha subunit
SCN5A sodium channel, voltage gated, type V alpha subunit
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCRIB scribbled planar cell polarity protein
SEPT2 septin 2
SEPT7 septin 7
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1
SESN3 sestrin 3
SETD8 SET domain containing (lysine methyltransferase) 8
SFTPA1 surfactant protein A1
SFTPD surfactant protein D
SGMS1 sphingomyelin synthase 1
SGMS2 sphingomyelin synthase 2
SH3GL2 SH3-domain GRB2-like 2
SIRT1 sirtuin 1
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC26A4 solute carrier family 26 (anion exchanger), member 4
SLC39A9 solute carrier family 39, member 9
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SMAD6 SMAD family member 6
SNAP23 synaptosomal-associated protein, 23kDa
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOD1 superoxide dismutase 1, soluble
SOD2 superoxide dismutase 2, mitochondrial
SOST sclerostin
SOX11 SRY (sex determining region Y)-box 11
SP1 Sp1 transcription factor
SP3 Sp3 transcription factor
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
SPOP speckle-type POZ protein
SPRY2 sprouty homolog 2 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STIM1 stromal interaction molecule 1
STIM2 stromal interaction molecule 2
STIP1 stress-induced phosphoprotein 1
STK11 serine/threonine kinase 11
STK39 serine threonine kinase 39
STMN1 stathmin 1
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
STXBP1 syntaxin binding protein 1
STXBP2 syntaxin binding protein 2
SUMO1 small ubiquitin-like modifier 1
TACSTD2 tumor-associated calcium signal transducer 2
TBX1 T-box 1
TCF3 transcription factor 3
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TERT telomerase reverse transcriptase
TEX14 testis expressed 14
TFF3 trefoil factor 3 (intestinal)
TGFB1 transforming growth factor, beta 1
TGFBR1 transforming growth factor, beta receptor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGFBR3 transforming growth factor, beta receptor III
TGM2 transglutaminase 2
TIGIT T cell immunoreceptor with Ig and ITIM domains
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TMEM25 transmembrane protein 25
TNF tumor necrosis factor
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TNNC1 troponin C type 1 (slow)
TNNI3 troponin I type 3 (cardiac)
TOP2A topoisomerase (DNA) II alpha 170kDa
TOP2B topoisomerase (DNA) II beta 180kDa
TP53 tumor protein p53
TRIM5 tripartite motif containing 5
TROVE2 TROVE domain family, member 2
TRPC1 transient receptor potential cation channel, subfamily C, member 1
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TUBB4A tubulin, beta 4A class IVa
TWIST2 twist family bHLH transcription factor 2
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGT1A4 UDP glucuronosyltransferase 1 family, polypeptide A4
USP22 ubiquitin specific peptidase 22
VCAM1 vascular cell adhesion molecule 1
VCAN versican
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VMP1 vacuole membrane protein 1
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
VWF von Willebrand factor
WNK1 WNK lysine deficient protein kinase 1
XKR8 XK, Kell blood group complex subunit-related family, member 8
XPC xeroderma pigmentosum, complementation group C
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
YBX2 Y box binding protein 2
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZEB1 zinc finger E-box binding homeobox 1
ZMYM4 zinc finger, MYM-type 4
ZNF365 zinc finger protein 365