altizide-2527 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the altizide-2527 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ACTA1 actin, alpha 1, skeletal muscle
AGGF1 angiogenic factor with G patch and FHA domains 1
ANO2 anoctamin 2, calcium activated chloride channel
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10
BAAT bile acid CoA:amino acid N-acyltransferase
C14ORF105 chromosome 14 open reading frame 105
CALB2 calbindin 2
CALD1 caldesmon 1
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCDC132 coiled-coil domain containing 132
CCL13 chemokine (C-C motif) ligand 13
CCL22 chemokine (C-C motif) ligand 22
CD3D CD3d molecule, delta (CD3-TCR complex)
CD7 CD7 molecule
CDC14A cell division cycle 14A
CHRNE cholinergic receptor, nicotinic, epsilon (muscle)
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5
CLCA2 chloride channel accessory 2
CRTC1 CREB regulated transcription coactivator 1
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CYHR1 cysteine/histidine-rich 1
CYP4F8 cytochrome P450, family 4, subfamily F, polypeptide 8
DGKE diacylglycerol kinase, epsilon 64kDa
DPT dermatopontin
DZIP3 DAZ interacting zinc finger protein 3
EFNB3 ephrin-B3
EMC3 ER membrane protein complex subunit 3
FAM215A family with sequence similarity 215, member A (non-protein coding)
FDPS farnesyl diphosphate synthase
FGFR3 fibroblast growth factor receptor 3
FUT5 fucosyltransferase 5 (alpha (1,3) fucosyltransferase)
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1
GLS2 glutaminase 2 (liver, mitochondrial)
GPR107 G protein-coupled receptor 107
HCFC1 host cell factor C1
HCRTR2 hypocretin (orexin) receptor 2
HIST1H1B histone cluster 1, H1b
HLA-DRB4 major histocompatibility complex, class II, DR beta 4
HOXC5 homeobox C5
IFNA4 interferon, alpha 4
IGF2-AS IGF2 antisense RNA
KERA keratocan
KIF25 kinesin family member 25
KLKB1 kallikrein B, plasma (Fletcher factor) 1
KRT31 keratin 31, type I
KRT86 keratin 86, type II
LAMA4 laminin, alpha 4
LAMB4 laminin, beta 4
LENEP lens epithelial protein
LMF1 lipase maturation factor 1
LRRC49 leucine rich repeat containing 49
LTA lymphotoxin alpha
LTBP2 latent transforming growth factor beta binding protein 2
LY6G5C lymphocyte antigen 6 complex, locus G5C
LY6G6C lymphocyte antigen 6 complex, locus G6C
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MGAT4C MGAT4 family, member C
MXD4 MAX dimerization protein 4
MYH11 myosin, heavy chain 11, smooth muscle
NIPAL2 NIPA-like domain containing 2
NMT2 N-myristoyltransferase 2
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OR10C1 olfactory receptor, family 10, subfamily C, member 1 (gene/pseudogene)
OR10H3 olfactory receptor, family 10, subfamily H, member 3
OR12D3 olfactory receptor, family 12, subfamily D, member 3
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PEAK1 pseudopodium-enriched atypical kinase 1
PHYHIP phytanoyl-CoA 2-hydroxylase interacting protein
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4
PLK2 polo-like kinase 2
PLSCR3 phospholipid scramblase 3
PROX1 prospero homeobox 1
PRSS23 protease, serine, 23
RARA retinoic acid receptor, alpha
RDH5 retinol dehydrogenase 5 (11-cis/9-cis)
RHOD ras homolog family member D
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila)
RPS4Y1 ribosomal protein S4, Y-linked 1
RTEL1 regulator of telomere elongation helicase 1
RUFY3 RUN and FYVE domain containing 3
RUNX1 runt-related transcription factor 1
SCN11A sodium channel, voltage gated, type XI alpha subunit
SEMG1 semenogelin I
SEZ6L seizure related 6 homolog (mouse)-like
SIGLEC7 sialic acid binding Ig-like lectin 7
SIX2 SIX homeobox 2
SLC22A14 solute carrier family 22, member 14
SLCO1B1 solute carrier organic anion transporter family, member 1B1
SMAD3 SMAD family member 3
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SOX4 SRY (sex determining region Y)-box 4
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRD T cell receptor delta locus
TRIM2 tripartite motif containing 2
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VCX2 variable charge, X-linked 2
WNT3 wingless-type MMTV integration site family, member 3
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ADAM15 ADAM metallopeptidase domain 15
AGPS alkylglycerone phosphate synthase
ANKFY1 ankyrin repeat and FYVE domain containing 1
AP4M1 adaptor-related protein complex 4, mu 1 subunit
APOL6 apolipoprotein L, 6
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2
ARRB1 arrestin, beta 1
ASB7 ankyrin repeat and SOCS box containing 7
AXIN1 axin 1
BRIP1 BRCA1 interacting protein C-terminal helicase 1
CCS copper chaperone for superoxide dismutase
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CD101 CD101 molecule
CDK20 cyclin-dependent kinase 20
CHML choroideremia-like (Rab escort protein 2)
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
DHRS11 dehydrogenase/reductase (SDR family) member 11
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
ERCC4 excision repair cross-complementation group 4
F8 coagulation factor VIII, procoagulant component
FAM222B family with sequence similarity 222, member B
FAM63B family with sequence similarity 63, member B
FHIT fragile histidine triad
FLT4 fms-related tyrosine kinase 4
FOXN2 forkhead box N2
GMEB1 glucocorticoid modulatory element binding protein 1
GTF2I general transcription factor IIi
HAUS6 HAUS augmin-like complex, subunit 6
HCAR3 hydroxycarboxylic acid receptor 3
HDHD3 haloacid dehalogenase-like hydrolase domain containing 3
HIST1H2BI histone cluster 1, H2bi
HIST1H3B histone cluster 1, H3b
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HPSE heparanase
HSPA1L heat shock 70kDa protein 1-like
IFT81 intraflagellar transport 81
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IPO8 importin 8
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KRI1 KRI1 homolog (S. cerevisiae)
KRT81 keratin 81, type II
LMAN1 lectin, mannose-binding, 1
LONRF3 LON peptidase N-terminal domain and ring finger 3
LSP1 lymphocyte-specific protein 1
LTC4S leukotriene C4 synthase
MBTD1 mbt domain containing 1
MCOLN1 mucolipin 1
MEGF8 multiple EGF-like-domains 8
MOCS3 molybdenum cofactor synthesis 3
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
NDE1 nudE neurodevelopment protein 1
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NPIPB3 nuclear pore complex interacting protein family, member B3
NUDT2 nudix (nucleoside diphosphate linked moiety X)-type motif 2
PLS1 plastin 1
POLH polymerase (DNA directed), eta
PPDPF pancreatic progenitor cell differentiation and proliferation factor
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like
RAB3A RAB3A, member RAS oncogene family
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RHOC ras homolog family member C
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RNF141 ring finger protein 141
RPL13P5 ribosomal protein L13 pseudogene 5
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SOAT1 sterol O-acyltransferase 1
SPA17 sperm autoantigenic protein 17
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STX5 syntaxin 5
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TBC1D17 TBC1 domain family, member 17
TCEA2 transcription elongation factor A (SII), 2
TEP1 telomerase-associated protein 1
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
THBS3 thrombospondin 3
THRAP3 thyroid hormone receptor associated protein 3
TOM1 target of myb1 (chicken)
TPRA1 transmembrane protein, adipocyte asscociated 1
TPST2 tyrosylprotein sulfotransferase 2
TRIM26 tripartite motif containing 26
TWSG1 twisted gastrulation BMP signaling modulator 1
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae)
YIPF4 Yip1 domain family, member 4
ZMAT5 zinc finger, matrin-type 5
ZNF226 zinc finger protein 226
ZNF32 zinc finger protein 32
ZNF37BP zinc finger protein 37B, pseudogene
ZNF665 zinc finger protein 665
ZNF675 zinc finger protein 675
ZNF768 zinc finger protein 768
ZNF83 zinc finger protein 83
ZSCAN16 zinc finger and SCAN domain containing 16