altizide-6089 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the altizide-6089 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAN aggrecan
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADGRA2 adhesion G protein-coupled receptor A2
AKAP1 A kinase (PRKA) anchor protein 1
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AMELY amelogenin, Y-linked
AQP6 aquaporin 6, kidney specific
BAIAP3 BAI1-associated protein 3
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
C19ORF57 chromosome 19 open reading frame 57
C19ORF66 chromosome 19 open reading frame 66
CCL11 chemokine (C-C motif) ligand 11
CCL2 chemokine (C-C motif) ligand 2
CDK13 cyclin-dependent kinase 13
CXCL6 chemokine (C-X-C motif) ligand 6
CYBB cytochrome b-245, beta polypeptide
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
EXOC6B exocyst complex component 6B
FGFR2 fibroblast growth factor receptor 2
FKRP fukutin related protein
FUT5 fucosyltransferase 5 (alpha (1,3) fucosyltransferase)
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
GBP2 guanylate binding protein 2, interferon-inducible
GPR68 G protein-coupled receptor 68
GSTTP1 glutathione S-transferase theta pseudogene 1
HFE hemochromatosis
HNF1B HNF1 homeobox B
HYAL1 hyaluronoglucosaminidase 1
IFFO1 intermediate filament family orphan 1
IL11 interleukin 11
IPW imprinted in Prader-Willi syndrome (non-protein coding)
IRF8 interferon regulatory factor 8
ITGB7 integrin, beta 7
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIF26B kinesin family member 26B
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KRT15 keratin 15, type I
LMX1B LIM homeobox transcription factor 1, beta
MAGEA8 melanoma antigen family A8
MAPK8 mitogen-activated protein kinase 8
MGAT3 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
MNMIP1 manchette microtubule inner protein 1
MST1 macrophage stimulating 1
MXRA5 matrix-remodelling associated 5
NABP1 nucleic acid binding protein 1
NLGN4X neuroligin 4, X-linked
OLFML2B olfactomedin-like 2B
OTOR otoraplin
PAPPA2 pappalysin 2
PAX8 paired box 8
PCDH7 protocadherin 7
PDLIM3 PDZ and LIM domain 3
PHLDB1 pleckstrin homology-like domain, family B, member 1
PLXNB3 plexin B3
PML promyelocytic leukemia
PODNL1 podocan-like 1
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PRM1 protamine 1
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RAI1 retinoic acid induced 1
RELN reelin
RPL23AP53 ribosomal protein L23a pseudogene 53
RPL35A ribosomal protein L35a
RPS4Y1 ribosomal protein S4, Y-linked 1
RTEL1 regulator of telomere elongation helicase 1
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
SIGLEC7 sialic acid binding Ig-like lectin 7
SLAMF8 SLAM family member 8
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLN sarcolipin
SMG6 SMG6 nonsense mediated mRNA decay factor
SNCAIP synuclein, alpha interacting protein
SNTA1 syntrophin, alpha 1
SOCS7 suppressor of cytokine signaling 7
SOX10 SRY (sex determining region Y)-box 10
SRCAP Snf2-related CREBBP activator protein
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3
STON1 stonin 1
STS steroid sulfatase (microsomal), isozyme S
TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TCL6 T-cell leukemia/lymphoma 6 (non-protein coding)
THBS3 thrombospondin 3
TLE2 transducin-like enhancer of split 2
TLX3 T-cell leukemia homeobox 3
TM4SF5 transmembrane 4 L six family member 5
TP63 tumor protein p63
TTLL4 tubulin tyrosine ligase-like family member 4
UCN urocortin
UMOD uromodulin
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
ZFPL1 zinc finger protein-like 1
ZMYND10 zinc finger, MYND-type containing 10
ZNF518A zinc finger protein 518A
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
ACTL8 actin-like 8
ANP32A-IT1 ANP32A intronic transcript 1
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ARPIN actin-related protein 2/3 complex inhibitor
BAHCC1 BAH domain and coiled-coil containing 1
BMP15 bone morphogenetic protein 15
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
C2ORF27A chromosome 2 open reading frame 27A
C2ORF54 chromosome 2 open reading frame 54
C3ORF18 chromosome 3 open reading frame 18
CA5BP1 carbonic anhydrase VB pseudogene 1
CEMIP cell migration inducing protein, hyaluronan binding
CES3 carboxylesterase 3
CHPF chondroitin polymerizing factor
COPZ2 coatomer protein complex, subunit zeta 2
CRYGC crystallin, gamma C
CSTA cystatin A (stefin A)
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DGAT1 diacylglycerol O-acyltransferase 1
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DNAH17 dynein, axonemal, heavy chain 17
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
EFNA3 ephrin-A3
ETNK2 ethanolamine kinase 2
F3 coagulation factor III (thromboplastin, tissue factor)
FAM189A2 family with sequence similarity 189, member A2
FBXO22 F-box protein 22
FBXO31 F-box protein 31
FGD1 FYVE, RhoGEF and PH domain containing 1
GRPR gastrin-releasing peptide receptor
HIST1H2AJ histone cluster 1, H2aj
HIST1H3B histone cluster 1, H3b
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
HSPA1L heat shock 70kDa protein 1-like
ING4 inhibitor of growth family, member 4
IQCC IQ motif containing C
IRF2BP1 interferon regulatory factor 2 binding protein 1
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
KIAA0125 KIAA0125
KIAA0319L KIAA0319-like
KIF13A kinesin family member 13A
KIF13B kinesin family member 13B
KLF2 Kruppel-like factor 2
KRT24 keratin 24, type I
LMBR1L limb development membrane protein 1-like
LRRC37A3 leucine rich repeat containing 37, member A3
LRRC61 leucine rich repeat containing 61
MALL mal, T-cell differentiation protein-like
MAST3 microtubule associated serine/threonine kinase 3
MRPL52 mitochondrial ribosomal protein L52
MSI1 musashi RNA-binding protein 1
MVD mevalonate (diphospho) decarboxylase
MYLK myosin light chain kinase
NDE1 nudE neurodevelopment protein 1
NTF3 neurotrophin 3
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PCDH12 protocadherin 12
PCSK7 proprotein convertase subtilisin/kexin type 7
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PDGFD platelet derived growth factor D
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLCD1 phospholipase C, delta 1
PMCH pro-melanin-concentrating hormone
PMCHL1 pro-melanin-concentrating hormone-like 1, pseudogene
POLL polymerase (DNA directed), lambda
PTK6 protein tyrosine kinase 6
RAB3A RAB3A, member RAS oncogene family
RPH3AL rabphilin 3A-like (without C2 domains)
SCN1B sodium channel, voltage gated, type I beta subunit
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SETD1A SET domain containing 1A
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SRPX sushi-repeat containing protein, X-linked
ST5 suppression of tumorigenicity 5
STARD3 StAR-related lipid transfer (START) domain containing 3
TGFBR1 transforming growth factor, beta receptor 1
TGFBR3 transforming growth factor, beta receptor III
TMC5 transmembrane channel-like 5
TMEM104 transmembrane protein 104
TMEM120B transmembrane protein 120B
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMLHE trimethyllysine hydroxylase, epsilon
TNRC6B trinucleotide repeat containing 6B
TUBA3C tubulin, alpha 3c
UPP1 uridine phosphorylase 1
USB1 U6 snRNA biogenesis 1
YIF1B Yip1 interacting factor homolog B (S. cerevisiae)
ZBTB48 zinc finger and BTB domain containing 48
ZNF532 zinc finger protein 532
ZSCAN2 zinc finger and SCAN domain containing 2