altretamine-5688 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

193 genes differentially expressed following the altretamine-5688 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2
ACAA2 acetyl-CoA acyltransferase 2
ALX4 ALX homeobox 4
ARHGAP24 Rho GTPase activating protein 24
AVPR2 arginine vasopressin receptor 2
BCAM basal cell adhesion molecule (Lutheran blood group)
C5ORF45 chromosome 5 open reading frame 45
CADM3 cell adhesion molecule 3
CD177 CD177 molecule
CD40LG CD40 ligand
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3
CELA3A chymotrypsin-like elastase family, member 3A
CFAP69 cilia and flagella associated protein 69
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CLDN15 claudin 15
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
CROCCP3 ciliary rootlet coiled-coil, rootletin pseudogene 3
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
CYP3A7 cytochrome P450, family 3, subfamily A, polypeptide 7
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2
DCN decorin
DOCK9 dedicator of cytokinesis 9
EFCAB11 EF-hand calcium binding domain 11
ELSPBP1 epididymal sperm binding protein 1
ERO1LB ERO1-like beta (S. cerevisiae)
FADS2 fatty acid desaturase 2
FGL2 fibrinogen-like 2
FOXG1 forkhead box G1
GPM6B glycoprotein M6B
GPR22 G protein-coupled receptor 22
HFE hemochromatosis
ICOSLG inducible T-cell co-stimulator ligand
IL1R1 interleukin 1 receptor, type I
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KLK2 kallikrein-related peptidase 2
LGALS9 lectin, galactoside-binding, soluble, 9
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LMX1B LIM homeobox transcription factor 1, beta
LY6G6C lymphocyte antigen 6 complex, locus G6C
LZTS3 leucine zipper, putative tumor suppressor family member 3
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
MCTP1 multiple C2 domains, transmembrane 1
MED16 mediator complex subunit 16
MNDA myeloid cell nuclear differentiation antigen
MOB3B MOB kinase activator 3B
MTSS1 metastasis suppressor 1
MYH15 myosin, heavy chain 15
NDOR1 NADPH dependent diflavin oxidoreductase 1
NEK1 NIMA-related kinase 1
NFX1 nuclear transcription factor, X-box binding 1
NRP1 neuropilin 1
OR10H1 olfactory receptor, family 10, subfamily H, member 1
OVOL1 ovo-like zinc finger 1
PDE4D phosphodiesterase 4D, cAMP-specific
PHF1 PHD finger protein 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLEKHO2 pleckstrin homology domain containing, family O member 2
PRND prion protein 2 (dublet)
PRX periaxin
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C)
RAB3A RAB3A, member RAS oncogene family
RASIP1 Ras interacting protein 1
RBM12B RNA binding motif protein 12B
RGS12 regulator of G-protein signaling 12
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SH2D3A SH2 domain containing 3A
SIRT4 sirtuin 4
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC6A16 solute carrier family 6, member 16
SMR3A submaxillary gland androgen regulated protein 3A
SNTA1 syntrophin, alpha 1
SOX21 SRY (sex determining region Y)-box 21
SPAG8 sperm associated antigen 8
SYT13 synaptotagmin XIII
TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TBC1D2B TBC1 domain family, member 2B
TCP10 t-complex 10
TCP11L1 t-complex 11, testis-specific-like 1
THBS3 thrombospondin 3
TMEM242 transmembrane protein 242
TMLHE trimethyllysine hydroxylase, epsilon
TP63 tumor protein p63
TPSB2 tryptase beta 2 (gene/pseudogene)
TRA T cell receptor alpha locus
TRPC6 transient receptor potential cation channel, subfamily C, member 6
UTS2 urotensin 2
VRTN vertebrae development associated
WDR55 WD repeat domain 55
WIF1 WNT inhibitory factor 1
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZNF37BP zinc finger protein 37B, pseudogene
ZP2 zona pellucida glycoprotein 2 (sperm receptor)

decreased expression

Symbol Name
ACADSB acyl-CoA dehydrogenase, short/branched chain
ADGRG2 adhesion G protein-coupled receptor G2
ALG12 ALG12, alpha-1,6-mannosyltransferase
AMT aminomethyltransferase
ARRB1 arrestin, beta 1
AXIN1 axin 1
BAG4 BCL2-associated athanogene 4
BMP15 bone morphogenetic protein 15
BTF3P12 basic transcription factor 3 pseudogene 12
C2ORF68 chromosome 2 open reading frame 68
CALCOCO1 calcium binding and coiled-coil domain 1
CAMTA1 calmodulin binding transcription activator 1
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CCDC176 coiled-coil domain containing 176
CCDC25 coiled-coil domain containing 25
CCDC88C coiled-coil domain containing 88C
CCP110 centriolar coiled coil protein 110kDa
CFD complement factor D (adipsin)
CGA glycoprotein hormones, alpha polypeptide
CIC capicua transcriptional repressor
COPS7B COP9 signalosome subunit 7B
CPSF3L cleavage and polyadenylation specific factor 3-like
CRABP1 cellular retinoic acid binding protein 1
CTC1 CTS telomere maintenance complex component 1
CXORF21 chromosome X open reading frame 21
ELOVL4 ELOVL fatty acid elongase 4
FAM169A family with sequence similarity 169, member A
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GPALPP1 GPALPP motifs containing 1
H2AFJ H2A histone family, member J
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase
HHLA3 HERV-H LTR-associating 3
HIST1H1D histone cluster 1, H1d
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HYAL2 hyaluronoglucosaminidase 2
IRF7 interferon regulatory factor 7
JMJD4 jumonji domain containing 4
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
KPNA4 karyopherin alpha 4 (importin alpha 3)
LAIR2 leukocyte-associated immunoglobulin-like receptor 2
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LIN37 lin-37 DREAM MuvB core complex component
MAN2C1 mannosidase, alpha, class 2C, member 1
MANBA mannosidase, beta A, lysosomal
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MED24 mediator complex subunit 24
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MXD3 MAX dimerization protein 3
NARFL nuclear prelamin A recognition factor-like
NES nestin
NR1H3 nuclear receptor subfamily 1, group H, member 3
NT5DC3 5'-nucleotidase domain containing 3
NXPE3 neurexophilin and PC-esterase domain family, member 3
OXR1 oxidation resistance 1
PCBP4 poly(rC) binding protein 4
PITX2 paired-like homeodomain 2
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
PRODH proline dehydrogenase (oxidase) 1
PRPH peripherin
PTPRE protein tyrosine phosphatase, receptor type, E
PYCRL pyrroline-5-carboxylate reductase-like
RAB3D RAB3D, member RAS oncogene family
RHOBTB1 Rho-related BTB domain containing 1
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
RPL13P5 ribosomal protein L13 pseudogene 5
SCGB2A2 secretoglobin, family 2A, member 2
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC26A6 solute carrier family 26 (anion exchanger), member 6
SLC44A1 solute carrier family 44 (choline transporter), member 1
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SNX10 sorting nexin 10
SPATA7 spermatogenesis associated 7
STAG3 stromal antigen 3
SUSD4 sushi domain containing 4
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast)
TNRC6B trinucleotide repeat containing 6B
TREM1 triggering receptor expressed on myeloid cells 1
UBL4A ubiquitin-like 4A
UBTD1 ubiquitin domain containing 1
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VEGFC vascular endothelial growth factor C
VGF VGF nerve growth factor inducible
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
WDR25 WD repeat domain 25
XK X-linked Kx blood group
XYLT2 xylosyltransferase II
ZNF286A zinc finger protein 286A
ZNF329 zinc finger protein 329
ZNF350 zinc finger protein 350
ZNF675 zinc finger protein 675
ZNF747 zinc finger protein 747
ZNF778 zinc finger protein 778