alverine-2110 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the alverine-2110 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9
ANKMY1 ankyrin repeat and MYND domain containing 1
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
APC adenomatous polyposis coli
APLP2 amyloid beta (A4) precursor-like protein 2
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
APP amyloid beta (A4) precursor protein
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ARSB arylsulfatase B
ATXN7L3B ataxin 7-like 3B
CPPED1 calcineurin-like phosphoesterase domain containing 1
CPT1A carnitine palmitoyltransferase 1A (liver)
CXCL5 chemokine (C-X-C motif) ligand 5
DCAF4 DDB1 and CUL4 associated factor 4
DHRS12 dehydrogenase/reductase (SDR family) member 12
DLX2 distal-less homeobox 2
DUSP1 dual specificity phosphatase 1
EGFL7 EGF-like-domain, multiple 7
EGFR epidermal growth factor receptor
ELOVL5 ELOVL fatty acid elongase 5
EPRS glutamyl-prolyl-tRNA synthetase
FCF1 FCF1 rRNA-processing protein
FGF5 fibroblast growth factor 5
FOXG1 forkhead box G1
GAL3ST4 galactose-3-O-sulfotransferase 4
GAS7 growth arrest-specific 7
GPER1 G protein-coupled estrogen receptor 1
H1F0 H1 histone family, member 0
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HN1L hematological and neurological expressed 1-like
HOOK1 hook microtubule-tethering protein 1
HOXB5 homeobox B5
ICOSLG inducible T-cell co-stimulator ligand
IFI6 interferon, alpha-inducible protein 6
IL15 interleukin 15
IL1RN interleukin 1 receptor antagonist
INPP5B inositol polyphosphate-5-phosphatase, 75kDa
ITFG2 integrin alpha FG-GAP repeat containing 2
JAK2 Janus kinase 2
KIAA1033 KIAA1033
LDB1 LIM domain binding 1
LMNA lamin A/C
LTBP4 latent transforming growth factor beta binding protein 4
LYPD3 LY6/PLAUR domain containing 3
MAPK14 mitogen-activated protein kinase 14
MCL1 myeloid cell leukemia 1
MDFIC MyoD family inhibitor domain containing
MET MET proto-oncogene, receptor tyrosine kinase
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MIIP migration and invasion inhibitory protein
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MT1F metallothionein 1F
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NKTR natural killer cell triggering receptor
NOL12 nucleolar protein 12
NR2F6 nuclear receptor subfamily 2, group F, member 6
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
PBX2 pre-B-cell leukemia homeobox 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDGFA platelet-derived growth factor alpha polypeptide
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PHF20L1 PHD finger protein 20-like 1
PKP3 plakophilin 3
PRF1 perforin 1 (pore forming protein)
PRR14L proline rich 14-like
RAB27B RAB27B, member RAS oncogene family
RRAD Ras-related associated with diabetes
RRN3P1 RNA polymerase I transcription factor homolog (S. cerevisiae) pseudogene 1
SARS2 seryl-tRNA synthetase 2, mitochondrial
SCAMP1 secretory carrier membrane protein 1
SCYL2 SCY1-like 2 (S. cerevisiae)
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SORBS2 sorbin and SH3 domain containing 2
STC1 stanniocalcin 1
STK4 serine/threonine kinase 4
STX6 syntaxin 6
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TCF4 transcription factor 4
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TIAM1 T-cell lymphoma invasion and metastasis 1
TLE3 transducin-like enhancer of split 3
TM2D1 TM2 domain containing 1
TMBIM1 transmembrane BAX inhibitor motif containing 1
TMEM180 transmembrane protein 180
TRAF4 TNF receptor-associated factor 4
TRIM25 tripartite motif containing 25
TSNAXIP1 translin-associated factor X interacting protein 1
TTLL7 tubulin tyrosine ligase-like family member 7
UBOX5 U-box domain containing 5
WDR4 WD repeat domain 4
WDR91 WD repeat domain 91
WIPI2 WD repeat domain, phosphoinositide interacting 2
ZBTB40 zinc finger and BTB domain containing 40
ZC3H7B zinc finger CCCH-type containing 7B
ZNF224 zinc finger protein 224
ZNF385D zinc finger protein 385D
ZNF669 zinc finger protein 669

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ACYP2 acylphosphatase 2, muscle type
ADCY7 adenylate cyclase 7
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like
ARRB2 arrestin, beta 2
ASCC2 activating signal cointegrator 1 complex subunit 2
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
AUH AU RNA binding protein/enoyl-CoA hydratase
BCL2L2 BCL2-like 2
BOLA1 bolA family member 1
C16ORF59 chromosome 16 open reading frame 59
C1ORF105 chromosome 1 open reading frame 105
C1ORF159 chromosome 1 open reading frame 159
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
CAMTA2 calmodulin binding transcription activator 2
CARD8 caspase recruitment domain family, member 8
CCDC176 coiled-coil domain containing 176
CCL20 chemokine (C-C motif) ligand 20
CDK3 cyclin-dependent kinase 3
CLUH clustered mitochondria (cluA/CLU1) homolog
CNTNAP1 contactin associated protein 1
CPSF7 cleavage and polyadenylation specific factor 7, 59kDa
CTSF cathepsin F
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
EFNA3 ephrin-A3
EPHB6 EPH receptor B6
FAM50B family with sequence similarity 50, member B
FAM53B family with sequence similarity 53, member B
FMO4 flavin containing monooxygenase 4
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GMIP GEM interacting protein
GUSBP3 glucuronidase, beta pseudogene 3
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIRA histone cell cycle regulator
HSPA2 heat shock 70kDa protein 2
IMPACT impact RWD domain protein
IREB2 iron-responsive element binding protein 2
IRF2BP1 interferon regulatory factor 2 binding protein 1
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
KRT86 keratin 86, type II
KRT8P12 keratin 8 pseudogene 12
LMCD1 LIM and cysteine-rich domains 1
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LRRC61 leucine rich repeat containing 61
MAN2C1 mannosidase, alpha, class 2C, member 1
MOXD1 monooxygenase, DBH-like 1
MTMR6 myotubularin related protein 6
NOTCH1 notch 1
NPFFR1 neuropeptide FF receptor 1
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3
NUP62CL nucleoporin 62kDa C-terminal like
OVGP1 oviductal glycoprotein 1, 120kDa
PC pyruvate carboxylase
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLD2 phospholipase D2
PLD3 phospholipase D family, member 3
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLXNA3 plexin A3
PRMT7 protein arginine methyltransferase 7
PTPN9 protein tyrosine phosphatase, non-receptor type 9
RAB4B RAB4B, member RAS oncogene family
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RIN1 Ras and Rab interactor 1
SAMD9 sterile alpha motif domain containing 9
SCAI suppressor of cancer cell invasion
SCEL sciellin
SEC14L2 SEC14-like 2 (S. cerevisiae)
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SIX1 SIX homeobox 1
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
SNIP1 Smad nuclear interacting protein 1
SNTA1 syntrophin, alpha 1
SOD3 superoxide dismutase 3, extracellular
SPEG SPEG complex locus
STIM1 stromal interaction molecule 1
TBC1D17 TBC1 domain family, member 17
THBS3 thrombospondin 3
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TOLLIP toll interacting protein
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
TRMT61A tRNA methyltransferase 61A
TTBK2 tau tubulin kinase 2
TUBA3C tubulin, alpha 3c
TUBA3D tubulin, alpha 3d
UBQLN4 ubiquilin 4
WNT7A wingless-type MMTV integration site family, member 7A
ZNF282 zinc finger protein 282
ZNF408 zinc finger protein 408
ZNF551 zinc finger protein 551
ZNF592 zinc finger protein 592
ZNF804A zinc finger protein 804A
ZNF84 zinc finger protein 84
ZNF862 zinc finger protein 862