alverine-6345 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the alverine-6345 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACVR1B activin A receptor, type IB
ADAM12 ADAM metallopeptidase domain 12
ANKLE2 ankyrin repeat and LEM domain containing 2
APOLD1 apolipoprotein L domain containing 1
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
ASIC4 acid sensing (proton gated) ion channel family member 4
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BAZ2A bromodomain adjacent to zinc finger domain, 2A
C9ORF40 chromosome 9 open reading frame 40
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CCS copper chaperone for superoxide dismutase
CD8B CD8b molecule
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
COL1A1 collagen, type I, alpha 1
CPNE7 copine VII
CREB3L1 cAMP responsive element binding protein 3-like 1
CRTC1 CREB regulated transcription coactivator 1
CSPP1 centrosome and spindle pole associated protein 1
DCTN1 dynactin 1
DHODH dihydroorotate dehydrogenase (quinone)
DMPK dystrophia myotonica-protein kinase
DNM3 dynamin 3
DST dystonin
EFNB3 ephrin-B3
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
EXOSC2 exosome component 2
FGFR1 fibroblast growth factor receptor 1
FH fumarate hydratase
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FOSL2 FOS-like antigen 2
FRMPD1 FERM and PDZ domain containing 1
FUBP1 far upstream element (FUSE) binding protein 1
GAS8 growth arrest-specific 8
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPR17 G protein-coupled receptor 17
HEXIM1 hexamethylene bis-acetamide inducible 1
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HNF1B HNF1 homeobox B
HOXC10 homeobox C10
HPN hepsin
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL5RA interleukin 5 receptor, alpha
INO80B INO80 complex subunit B
IQCK IQ motif containing K
IRAK4 interleukin-1 receptor-associated kinase 4
KIF1A kinesin family member 1A
KLHL20 kelch-like family member 20
LDB1 LIM domain binding 1
LRP6 low density lipoprotein receptor-related protein 6
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MAPK7 mitogen-activated protein kinase 7
MFN2 mitofusin 2
MID1 midline 1
MKL1 megakaryoblastic leukemia (translocation) 1
MST1 macrophage stimulating 1
MTAP methylthioadenosine phosphorylase
NAAA N-acylethanolamine acid amidase
NDE1 nudE neurodevelopment protein 1
NF1 neurofibromin 1
NUMA1 nuclear mitotic apparatus protein 1
OR2H2 olfactory receptor, family 2, subfamily H, member 2
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PARM1 prostate androgen-regulated mucin-like protein 1
PCGF3 polycomb group ring finger 3
PDCD2 programmed cell death 2
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa
PDLIM7 PDZ and LIM domain 7 (enigma)
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PLCL2 phospholipase C-like 2
PLD2 phospholipase D2
PLEKHA6 pleckstrin homology domain containing, family A member 6
PPP1R3D protein phosphatase 1, regulatory subunit 3D
PPP4R4 protein phosphatase 4, regulatory subunit 4
PRAMEF11 PRAME family member 11
PRB1 proline-rich protein BstNI subfamily 1
PRDX2 peroxiredoxin 2
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
RAB36 RAB36, member RAS oncogene family
RAD52 RAD52 homolog (S. cerevisiae)
RNF122 ring finger protein 122
RPL10 ribosomal protein L10
RYR2 ryanodine receptor 2 (cardiac)
SAFB scaffold attachment factor B
SETD8 SET domain containing (lysine methyltransferase) 8
SIRT6 sirtuin 6
SOGA1 suppressor of glucose, autophagy associated 1
STK24 serine/threonine kinase 24
TBC1D30 TBC1 domain family, member 30
TGFB2 transforming growth factor, beta 2
TM4SF1 transmembrane 4 L six family member 1
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TSFM Ts translation elongation factor, mitochondrial
TTLL3 tubulin tyrosine ligase-like family member 3
UBE4B ubiquitination factor E4B
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
VAV3 vav 3 guanine nucleotide exchange factor
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
ZFP30 ZFP30 zinc finger protein

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ABHD8 abhydrolase domain containing 8
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARL15 ADP-ribosylation factor-like 15
ARMCX2 armadillo repeat containing, X-linked 2
ARMCX4 armadillo repeat containing, X-linked 4
ATP13A2 ATPase type 13A2
BTF3P12 basic transcription factor 3 pseudogene 12
C11ORF63 chromosome 11 open reading frame 63
C1ORF35 chromosome 1 open reading frame 35
CCDC85C coiled-coil domain containing 85C
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDT1 chromatin licensing and DNA replication factor 1
CINP cyclin-dependent kinase 2 interacting protein
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
CTC1 CTS telomere maintenance complex component 1
CUL9 cullin 9
DCAF17 DDB1 and CUL4 associated factor 17
DHRS11 dehydrogenase/reductase (SDR family) member 11
DTX4 deltex 4, E3 ubiquitin ligase
DZANK1 double zinc ribbon and ankyrin repeat domains 1
EGF epidermal growth factor
ELP3 elongator acetyltransferase complex subunit 3
ERMAP erythroblast membrane-associated protein (Scianna blood group)
EVPL envoplakin
F3 coagulation factor III (thromboplastin, tissue factor)
FCHO1 FCH domain only 1
FOXA1 forkhead box A1
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GRPR gastrin-releasing peptide receptor
HDAC7 histone deacetylase 7
HOXC8 homeobox C8
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
KIAA0754 KIAA0754
KIF13B kinesin family member 13B
LSR lipolysis stimulated lipoprotein receptor
MAGEH1 melanoma antigen family H1
MAPK12 mitogen-activated protein kinase 12
MBTPS2 membrane-bound transcription factor peptidase, site 2
MCOLN1 mucolipin 1
MCTP1 multiple C2 domains, transmembrane 1
MVP major vault protein
MYOZ3 myozenin 3
NHEJ1 nonhomologous end-joining factor 1
OLFML2A olfactomedin-like 2A
OVGP1 oviductal glycoprotein 1, 120kDa
PADI1 peptidyl arginine deiminase, type I
PAQR4 progestin and adipoQ receptor family member IV
PCBP4 poly(rC) binding protein 4
PCSK7 proprotein convertase subtilisin/kexin type 7
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PDE12 phosphodiesterase 12
PID1 phosphotyrosine interaction domain containing 1
PIGL phosphatidylinositol glycan anchor biosynthesis, class L
PLA2G15 phospholipase A2, group XV
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
POMT2 protein-O-mannosyltransferase 2
PRSS16 protease, serine, 16 (thymus)
PTGES2 prostaglandin E synthase 2
PTGFR prostaglandin F receptor (FP)
RBM38 RNA binding motif protein 38
RNF146 ring finger protein 146
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
ROGDI rogdi homolog (Drosophila)
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SCML2 sex comb on midleg-like 2 (Drosophila)
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLITRK5 SLIT and NTRK-like family, member 5
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
STX1A syntaxin 1A (brain)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TESK2 testis-specific kinase 2
THBS3 thrombospondin 3
TIGD6 tigger transposable element derived 6
TLN1 talin 1
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TRIM21 tripartite motif containing 21
TRIM9 tripartite motif containing 9
TSKU tsukushi, small leucine rich proteoglycan
TSPAN15 tetraspanin 15
TTC17 tetratricopeptide repeat domain 17
TUBA3C tubulin, alpha 3c
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
ZC3H3 zinc finger CCCH-type containing 3
ZDHHC14 zinc finger, DHHC-type containing 14
ZFHX3 zinc finger homeobox 3
ZNF408 zinc finger protein 408
ZNF528 zinc finger protein 528
ZNF571 zinc finger protein 571
ZNF592 zinc finger protein 592
ZNF675 zinc finger protein 675
ZNF862 zinc finger protein 862
ZXDC ZXD family zinc finger C