alvespimycin-2673 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the alvespimycin-2673 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD3 abhydrolase domain containing 3
ADCK2 aarF domain containing kinase 2
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
ANGEL2 angel homolog 2 (Drosophila)
ATXN8OS ATXN8 opposite strand (non-protein coding)
BAG3 BCL2-associated athanogene 3
BGN biglycan
BLZF1 basic leucine zipper nuclear factor 1
CACYBP calcyclin binding protein
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCNG2 cyclin G2
CD84 CD84 molecule
CDC14A cell division cycle 14A
CEP295 centrosomal protein 295kDa
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLK1 CDC-like kinase 1
COBLL1 cordon-bleu WH2 repeat protein-like 1
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
CREM cAMP responsive element modulator
CRYZ crystallin, zeta (quinone reductase)
DGKG diacylglycerol kinase, gamma 90kDa
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
EDN2 endothelin 2
ENGASE endo-beta-N-acetylglucosaminidase
FAM13A family with sequence similarity 13, member A
FAS Fas cell surface death receptor
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FKBP4 FK506 binding protein 4, 59kDa
FOXO4 forkhead box O4
FXR1 fragile X mental retardation, autosomal homolog 1
GK3P glycerol kinase 3 pseudogene
GPR132 G protein-coupled receptor 132
HBP1 HMG-box transcription factor 1
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4
HIBCH 3-hydroxyisobutyryl-CoA hydrolase
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA4 heat shock 70kDa protein 4
HSPA4L heat shock 70kDa protein 4-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IGHM immunoglobulin heavy constant mu
IL3RA interleukin 3 receptor, alpha (low affinity)
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KRIT1 KRIT1, ankyrin repeat containing
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2
LIMK2 LIM domain kinase 2
LMF1 lipase maturation factor 1
LPP LIM domain containing preferred translocation partner in lipoma
MAOA monoamine oxidase A
MBNL2 muscleblind-like splicing regulator 2
MBOAT7 membrane bound O-acyltransferase domain containing 7
MCL1 myeloid cell leukemia 1
MCTP2 multiple C2 domains, transmembrane 2
MICB MHC class I polypeptide-related sequence B
MORC3 MORC family CW-type zinc finger 3
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MTUS1 microtubule associated tumor suppressor 1
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NPEPL1 aminopeptidase-like 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PCDH9 protocadherin 9
PDE4B phosphodiesterase 4B, cAMP-specific
PDE4DIP phosphodiesterase 4D interacting protein
PHACTR1 phosphatase and actin regulator 1
PHTF1 putative homeodomain transcription factor 1
PPID peptidylprolyl isomerase D
PRKACB protein kinase, cAMP-dependent, catalytic, beta
SCAND2P SCAN domain containing 2 pseudogene
SEC24A SEC24 family member A
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SLC35D2 solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SMPX small muscle protein, X-linked
SNAP23 synaptosomal-associated protein, 23kDa
SPATS2L spermatogenesis associated, serine-rich 2-like
SRSF5 serine/arginine-rich splicing factor 5
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
STIP1 stress-induced phosphoprotein 1
STON1 stonin 1
THBS1 thrombospondin 1
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14
TTC30A tetratricopeptide repeat domain 30A
VAMP4 vesicle-associated membrane protein 4
ZNF675 zinc finger protein 675

decreased expression

Symbol Name
ADGB androglobin
AEN apoptosis enhancing nuclease
BATF3 basic leucine zipper transcription factor, ATF-like 3
BHLHE41 basic helix-loop-helix family, member e41
C10ORF2 chromosome 10 open reading frame 2
C22ORF46 chromosome 22 open reading frame 46
C7ORF69 chromosome 7 open reading frame 69
C8A complement component 8, alpha polypeptide
CCDC92 coiled-coil domain containing 92
CD34 CD34 molecule
CD79B CD79b molecule, immunoglobulin-associated beta
CD82 CD82 molecule
CDHR2 cadherin-related family member 2
CGA glycoprotein hormones, alpha polypeptide
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CRYGC crystallin, gamma C
CYP39A1 cytochrome P450, family 39, subfamily A, polypeptide 1
DDN dendrin
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DHODH dihydroorotate dehydrogenase (quinone)
DSPP dentin sialophosphoprotein
EHD3 EH-domain containing 3
EYA3 EYA transcriptional coactivator and phosphatase 3
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FBXL2 F-box and leucine-rich repeat protein 2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXRED2 FAD-dependent oxidoreductase domain containing 2
FRMPD1 FERM and PDZ domain containing 1
FRS3 fibroblast growth factor receptor substrate 3
GMPPA GDP-mannose pyrophosphorylase A
GPR3 G protein-coupled receptor 3
HIST1H1E histone cluster 1, H1e
HIST1H2AI histone cluster 1, H2ai
HIST1H2BI histone cluster 1, H2bi
HPR haptoglobin-related protein
IDI2-AS1 IDI2 antisense RNA 1
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase
ITGA10 integrin, alpha 10
KDM8 lysine (K)-specific demethylase 8
KLF13 Kruppel-like factor 13
KLHL36 kelch-like family member 36
KRT81 keratin 81, type II
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LRRK1 leucine-rich repeat kinase 1
MARC1 mitochondrial amidoxime reducing component 1
MCPH1 microcephalin 1
MIR22HG MIR22 host gene
MLPH melanophilin
MNX1 motor neuron and pancreas homeobox 1
MTSS1L metastasis suppressor 1-like
MXD3 MAX dimerization protein 3
MYBBP1A MYB binding protein (P160) 1a
MYH15 myosin, heavy chain 15
NACA2 nascent polypeptide-associated complex alpha subunit 2
NAG18 NAG18 mRNA
NFE2L3 nuclear factor, erythroid 2-like 3
NNAT neuronatin
NR1D2 nuclear receptor subfamily 1, group D, member 2
NSUN6 NOP2/Sun domain family, member 6
NXF2 nuclear RNA export factor 2
ODF2 outer dense fiber of sperm tails 2
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
P2RY11 purinergic receptor P2Y, G-protein coupled, 11
PES1 pescadillo ribosomal biogenesis factor 1
PIGH phosphatidylinositol glycan anchor biosynthesis, class H
PLAT plasminogen activator, tissue
POM121L2 POM121 transmembrane nucleoporin-like 2
PRDM12 PR domain containing 12
PRF1 perforin 1 (pore forming protein)
PRICKLE3 prickle homolog 3 (Drosophila)
PRSS53 protease, serine, 53
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAPSN receptor-associated protein of the synapse
RGS16 regulator of G-protein signaling 16
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCN10A sodium channel, voltage gated, type X alpha subunit
SIX3 SIX homeobox 3
SLC12A8 solute carrier family 12, member 8
SLC16A6 solute carrier family 16, member 6
SYNPO2L synaptopodin 2-like
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TCTA T-cell leukemia translocation altered
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
THEM6 thioesterase superfamily member 6
TMEM212 transmembrane protein 212
TNF tumor necrosis factor
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TNS2 tensin 2
TPM3 tropomyosin 3
TSPAN32 tetraspanin 32
UPB1 ureidopropionase, beta
USB1 U6 snRNA biogenesis 1
USP36 ubiquitin specific peptidase 36
ZNF667 zinc finger protein 667