| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/5488548 |
| Similar Terms | |
| Downloads & Tools |
198 proteins with high or low expression in alvimopan relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HELQ | helicase, POLQ-like | 0.55 |
| SFR1 | SWI5-dependent recombination repair 1 | 0.44 |
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.44 |
| HOXB9 | homeobox B9 | 0.44 |
| HOXA10 | homeobox A10 | 0.43 |
| H3C1 | H3 clustered histone 1 | 0.42 |
| PKNOX1 | PBX/knotted 1 homeobox 1 | 0.42 |
| MKX | mohawk homeobox | 0.41 |
| BHLHA15 | basic helix-loop-helix family, member a15 | 0.41 |
| TMEM98 | transmembrane protein 98 | 0.4 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | 0.37 |
| PDGFC | platelet derived growth factor C | 0.37 |
| PCGF3 | polycomb group ring finger 3 | 0.36 |
| NAAA | N-acylethanolamine acid amidase | 0.35 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | 0.35 |
| TMEM64 | transmembrane protein 64 | 0.35 |
| ZNF239 | zinc finger protein 239 | 0.34 |
| EXPH5 | exophilin 5 | 0.33 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | 0.33 |
| NUDT14 | nudix (nucleoside diphosphate linked moiety X)-type motif 14 | 0.33 |
| COMMD6 | COMM domain containing 6 | 0.32 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.32 |
| NDUFAB1 | NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa | 0.32 |
| ZNF711 | zinc finger protein 711 | 0.31 |
| CDC42EP2 | CDC42 effector protein (Rho GTPase binding) 2 | 0.31 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.3 |
| SYTL1 | synaptotagmin-like 1 | 0.3 |
| PLD1 | phospholipase D1, phosphatidylcholine-specific | 0.3 |
| FAM135A | family with sequence similarity 135, member A | 0.29 |
| SLC25A38 | solute carrier family 25, member 38 | 0.28 |
| TMPO | thymopoietin | 0.28 |
| C12ORF4 | chromosome 12 open reading frame 4 | 0.28 |
| PKHD1L1 | polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1 | 0.27 |
| KLHL25 | kelch-like family member 25 | 0.27 |
| RMND5B | required for meiotic nuclear division 5 homolog B (S. cerevisiae) | 0.27 |
| PRXL2A | peroxiredoxin like 2A | 0.27 |
| CACNB3 | calcium channel, voltage-dependent, beta 3 subunit | 0.27 |
| FGG | fibrinogen gamma chain | 0.27 |
| EIF4EBP2 | eukaryotic translation initiation factor 4E binding protein 2 | 0.27 |
| SLC7A6 | solute carrier family 7 (amino acid transporter light chain, y+L system), member 6 | 0.26 |
| SIMC1 | SUMO-interacting motifs containing 1 | 0.26 |
| KIAA1109 | KIAA1109 | 0.26 |
| MID1IP1 | MID1 interacting protein 1 | 0.26 |
| IMMT | inner membrane protein, mitochondrial | 0.26 |
| ZCCHC10 | zinc finger, CCHC domain containing 10 | 0.25 |
| TSPAN4 | tetraspanin 4 | 0.25 |
| COL2A1 | collagen, type II, alpha 1 | 0.25 |
| LYSMD1 | LysM, putative peptidoglycan-binding, domain containing 1 | 0.25 |
| FBXW9 | F-box and WD repeat domain containing 9 | 0.24 |
| RUNX3 | runt-related transcription factor 3 | 0.24 |
| ARL13B | ADP-ribosylation factor-like 13B | 0.24 |
| SELENOT | selenoprotein T | 0.24 |
| TTC39A | tetratricopeptide repeat domain 39A | 0.24 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.24 |
| RPGR | retinitis pigmentosa GTPase regulator | 0.24 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.23 |
| STMN2 | stathmin 2 | 0.23 |
| NCOR1 | nuclear receptor corepressor 1 | 0.23 |
| C8ORF76 | chromosome 8 open reading frame 76 | 0.23 |
| GPD1 | glycerol-3-phosphate dehydrogenase 1 (soluble) | 0.23 |
| CLIC6 | chloride intracellular channel 6 | 0.23 |
| PROSER3 | proline and serine rich 3 | 0.23 |
| ABCA7 | ATP-binding cassette, sub-family A (ABC1), member 7 | 0.23 |
| DAPK1 | death-associated protein kinase 1 | 0.23 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | 0.22 |
| APOB | apolipoprotein B | 0.22 |
| LRP11 | low density lipoprotein receptor-related protein 11 | 0.22 |
| TOMM5 | translocase of outer mitochondrial membrane 5 homolog (yeast) | 0.22 |
| CETN1 | centrin, EF-hand protein, 1 | 0.22 |
| GALNT4 | polypeptide N-acetylgalactosaminyltransferase 4 | 0.22 |
| ZNF160 | zinc finger protein 160 | 0.22 |
| CTDSP1 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 | 0.22 |
| BRK1 | BRICK1, SCAR/WAVE actin-nucleating complex subunit | 0.21 |
| TMCO4 | transmembrane and coiled-coil domains 4 | 0.21 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.21 |
| FASTK | Fas-activated serine/threonine kinase | 0.21 |
| FMNL1 | formin-like 1 | 0.21 |
| UBE2G2 | ubiquitin-conjugating enzyme E2G 2 | 0.21 |
| TIMM17B | translocase of inner mitochondrial membrane 17 homolog B (yeast) | 0.21 |
| GEN1 | GEN1 Holliday junction 5' flap endonuclease | 0.2 |
| ERCC6L2 | excision repair cross-complementation group 6-like 2 | 0.2 |
| MRPS18C | mitochondrial ribosomal protein S18C | 0.2 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.2 |
| DENND2D | DENN/MADD domain containing 2D | 0.2 |
| NECTIN3 | nectin cell adhesion molecule 3 | 0.2 |
| KLHL23 | kelch-like family member 23 | 0.2 |
| FGA | fibrinogen alpha chain | 0.2 |
| GRTP1 | growth hormone regulated TBC protein 1 | 0.2 |
| CPTP | ceramide-1-phosphate transfer protein | 0.2 |
| KIF18B | kinesin family member 18B | 0.2 |
| ACTL8 | actin-like 8 | 0.2 |
| AXIN1 | axin 1 | 0.2 |
| CRAT | carnitine O-acetyltransferase | 0.2 |
| CMPK2 | cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial | 0.2 |
| ACVR2A | activin A receptor, type IIA | 0.2 |
| PJA1 | praja ring finger 1, E3 ubiquitin protein ligase | 0.2 |
| CSNK1G3 | casein kinase 1, gamma 3 | 0.2 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.2 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ZFAND2A | zinc finger, AN1-type domain 2A | -1.49 |
| HBB | hemoglobin, beta | -1.41 |
| FAM171B | family with sequence similarity 171, member B | -0.92 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.88 |
| TMEM97 | transmembrane protein 97 | -0.73 |
| ATP8B2 | ATPase, aminophospholipid transporter, class I, type 8B, member 2 | -0.73 |
| LEPROTL1 | leptin receptor overlapping transcript-like 1 | -0.7 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | -0.66 |
| SGSH | N-sulfoglucosamine sulfohydrolase | -0.66 |
| CPLANE1 | ciliogenesis and planar polarity effector complex subunit 1 | -0.64 |
| ZBTB6 | zinc finger and BTB domain containing 6 | -0.62 |
| MIDN | midnolin | -0.62 |
| TMEM184A | transmembrane protein 184A | -0.62 |
| PPP2R3C | protein phosphatase 2, regulatory subunit B'', gamma | -0.61 |
| OSGIN1 | oxidative stress induced growth inhibitor 1 | -0.59 |
| AUNIP | aurora kinase A and ninein interacting protein | -0.56 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.56 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -0.56 |
| TMLHE | trimethyllysine hydroxylase, epsilon | -0.55 |
| FAM110C | family with sequence similarity 110, member C | -0.54 |
| ATP8B1 | ATPase, aminophospholipid transporter, class I, type 8B, member 1 | -0.54 |
| LRP1 | low density lipoprotein receptor-related protein 1 | -0.53 |
| ZNF460 | zinc finger protein 460 | -0.53 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.52 |
| TMEM59 | transmembrane protein 59 | -0.51 |
| MDM1 | Mdm1 nuclear protein homolog (mouse) | -0.51 |
| CLCN3 | chloride channel, voltage-sensitive 3 | -0.48 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.48 |
| ZC3H12C | zinc finger CCCH-type containing 12C | -0.48 |
| AXIN2 | axin 2 | -0.47 |
| VWDE | von Willebrand factor D and EGF domains | -0.47 |
| FTL | ferritin, light polypeptide | -0.46 |
| PDP2 | pyruvate dehyrogenase phosphatase catalytic subunit 2 | -0.46 |
| SKIL | SKI-like proto-oncogene | -0.44 |
| EPOP | elongin BC and polycomb repressive complex 2 associated protein | -0.44 |
| ZNF581 | zinc finger protein 581 | -0.43 |
| PXMP4 | peroxisomal membrane protein 4, 24kDa | -0.43 |
| MTERF2 | mitochondrial transcription termination factor 2 | -0.43 |
| DSTYK | dual serine/threonine and tyrosine protein kinase | -0.42 |
| TLL2 | tolloid-like 2 | -0.42 |
| DFFB | DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) | -0.42 |
| F13A1 | coagulation factor XIII, A1 polypeptide | -0.42 |
| CTSL | cathepsin L | -0.42 |
| SUCO | SUN domain containing ossification factor | -0.41 |
| KMT5C | lysine methyltransferase 5C | -0.4 |
| KMT2B | lysine (K)-specific methyltransferase 2B | -0.4 |
| TMEM39A | transmembrane protein 39A | -0.4 |
| NDFIP1 | Nedd4 family interacting protein 1 | -0.4 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.39 |
| ASAP3 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 | -0.39 |
| RAB6D | RAB6D, member RAS oncogene family | -0.39 |
| VAV1 | vav 1 guanine nucleotide exchange factor | -0.38 |
| SLC25A39 | solute carrier family 25, member 39 | -0.38 |
| UVRAG | UV radiation resistance associated | -0.37 |
| AZIN1 | antizyme inhibitor 1 | -0.37 |
| MACC1 | metastasis associated in colon cancer 1 | -0.36 |
| GPANK1 | G patch domain and ankyrin repeats 1 | -0.36 |
| CCDC102A | coiled-coil domain containing 102A | -0.35 |
| SEPHS2 | selenophosphate synthetase 2 | -0.35 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.35 |
| ATF3 | activating transcription factor 3 | -0.35 |
| BMERB1 | bMERB domain containing 1 | -0.34 |
| KLF2 | Kruppel-like factor 2 | -0.34 |
| OLFML3 | olfactomedin-like 3 | -0.34 |
| GGPS1 | geranylgeranyl diphosphate synthase 1 | -0.34 |
| SLC12A4 | solute carrier family 12 (potassium/chloride transporter), member 4 | -0.34 |
| RNF111 | ring finger protein 111 | -0.33 |
| NMNAT3 | nicotinamide nucleotide adenylyltransferase 3 | -0.33 |
| ABHD3 | abhydrolase domain containing 3 | -0.32 |
| AMOT | angiomotin | -0.32 |
| ASTE1 | asteroid homolog 1 (Drosophila) | -0.32 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.32 |
| BSDC1 | BSD domain containing 1 | -0.32 |
| SHC4 | SHC (Src homology 2 domain containing) family, member 4 | -0.31 |
| KIAA0100 | KIAA0100 | -0.3 |
| DCHS2 | dachsous cadherin-related 2 | -0.3 |
| ZNF205 | zinc finger protein 205 | -0.3 |
| ADCY10 | adenylate cyclase 10 (soluble) | -0.3 |
| KIFC3 | kinesin family member C3 | -0.3 |
| CD58 | CD58 molecule | -0.3 |
| KBTBD8 | kelch repeat and BTB (POZ) domain containing 8 | -0.3 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.29 |
| UPP1 | uridine phosphorylase 1 | -0.29 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.29 |
| UBXN2A | UBX domain protein 2A | -0.29 |
| ZNF655 | zinc finger protein 655 | -0.29 |
| MAP2 | microtubule-associated protein 2 | -0.29 |
| ZNF142 | zinc finger protein 142 | -0.29 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.28 |
| LCOR | ligand dependent nuclear receptor corepressor | -0.28 |
| LRRC58 | leucine rich repeat containing 58 | -0.28 |
| SPNS1 | spinster homolog 1 (Drosophila) | -0.28 |
| PDCD7 | programmed cell death 7 | -0.28 |
| ALOXE3 | arachidonate lipoxygenase 3 | -0.28 |
| ZNF600 | zinc finger protein 600 | -0.28 |
| ZER1 | zyg-11 related, cell cycle regulator | -0.28 |
| ABCD1 | ATP-binding cassette, sub-family D (ALD), member 1 | -0.27 |
| CNTN1 | contactin 1 | -0.27 |
| GIGYF1 | GRB10 interacting GYF protein 1 | -0.27 |
| KIAA0556 | KIAA0556 | -0.27 |
