amikacin-6715 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

193 genes differentially expressed following the amikacin-6715 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AIM2 absent in melanoma 2
AIRE autoimmune regulator
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit
APOD apolipoprotein D
ATP9A ATPase, class II, type 9A
ATRNL1 attractin-like 1
B3GNTL1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1
BGN biglycan
BMP2 bone morphogenetic protein 2
C10ORF12 chromosome 10 open reading frame 12
C22ORF31 chromosome 22 open reading frame 31
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CCDC7 coiled-coil domain containing 7
CFP complement factor properdin
CLTCL1 clathrin, heavy chain-like 1
CNGB3 cyclic nucleotide gated channel beta 3
CNOT4 CCR4-NOT transcription complex, subunit 4
COL3A1 collagen, type III, alpha 1
COMP cartilage oligomeric matrix protein
CTNS cystinosin, lysosomal cystine transporter
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
DCLK2 doublecortin-like kinase 2
DRICH1 aspartate-rich 1
E2F5 E2F transcription factor 5, p130-binding
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EGOT eosinophil granule ontogeny transcript (non-protein coding)
EGR2 early growth response 2
ERCC5 excision repair cross-complementation group 5
ESRRG estrogen-related receptor gamma
FBXO2 F-box protein 2
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
FN1 fibronectin 1
GPR1 G protein-coupled receptor 1
GPR135 G protein-coupled receptor 135
GREM1 gremlin 1, DAN family BMP antagonist
GUK1 guanylate kinase 1
HEMK1 HemK methyltransferase family member 1
HEXA hexosaminidase A (alpha polypeptide)
HOXC4 homeobox C4
IMPG1 interphotoreceptor matrix proteoglycan 1
ITPK1 inositol-tetrakisphosphate 1-kinase
JAK3 Janus kinase 3
KIR2DL2 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LMOD1 leiomodin 1 (smooth muscle)
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAOB monoamine oxidase B
MAPK8 mitogen-activated protein kinase 8
MBNL3 muscleblind-like splicing regulator 3
MED22 mediator complex subunit 22
MFAP3L microfibrillar-associated protein 3-like
MIR622 microRNA 622
MOBP myelin-associated oligodendrocyte basic protein
MRPL52 mitochondrial ribosomal protein L52
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic
MYH7 myosin, heavy chain 7, cardiac muscle, beta
N4BP2L1 NEDD4 binding protein 2-like 1
OAZ3 ornithine decarboxylase antizyme 3
P2RY1 purinergic receptor P2Y, G-protein coupled, 1
PDCD2 programmed cell death 2
PDE11A phosphodiesterase 11A
PRM2 protamine 2
RARB retinoic acid receptor, beta
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RBM12B RNA binding motif protein 12B
RBM12B-AS1 RBM12B antisense RNA 1
RPL14 ribosomal protein L14
RPL5 ribosomal protein L5
RPLP2 ribosomal protein, large, P2
RPS11 ribosomal protein S11
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC16A6 solute carrier family 16, member 6
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLCO1C1 solute carrier organic anion transporter family, member 1C1
SNTG1 syntrophin, gamma 1
SOX2 SRY (sex determining region Y)-box 2
SOX21 SRY (sex determining region Y)-box 21
SPRR2B small proline-rich protein 2B
ST8SIA3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
STK11 serine/threonine kinase 11
TBKBP1 TBK1 binding protein 1
TIMELESS timeless circadian clock
TMEM144 transmembrane protein 144
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TNS1 tensin 1
TRPM1 transient receptor potential cation channel, subfamily M, member 1
TTLL3 tubulin tyrosine ligase-like family member 3
UBE2I ubiquitin-conjugating enzyme E2I
USP22 ubiquitin specific peptidase 22
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
ZBTB20 zinc finger and BTB domain containing 20
ZNF214 zinc finger protein 214

decreased expression

Symbol Name
ABHD17B abhydrolase domain containing 17B
ADAM15 ADAM metallopeptidase domain 15
ADCY6 adenylate cyclase 6
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
AKIP1 A kinase (PRKA) interacting protein 1
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
AXIN1 axin 1
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BAK1 BCL2-antagonist/killer 1
BEX4 brain expressed, X-linked 4
BGLAP bone gamma-carboxyglutamate (gla) protein
BSG basigin (Ok blood group)
CARHSP1 calcium regulated heat stable protein 1, 24kDa
CCDC106 coiled-coil domain containing 106
CENPT centromere protein T
CEP131 centrosomal protein 131kDa
CHM choroideremia (Rab escort protein 1)
CLDN4 claudin 4
CORO1A coronin, actin binding protein, 1A
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DDA1 DET1 and DDB1 associated 1
DDIT3 DNA-damage-inducible transcript 3
DHDDS dehydrodolichyl diphosphate synthase
DPM2 dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EMP3 epithelial membrane protein 3
ETNK2 ethanolamine kinase 2
EXOC5 exocyst complex component 5
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FKBP5 FK506 binding protein 5
GALK1 galactokinase 1
GAMT guanidinoacetate N-methyltransferase
GDAP1 ganglioside induced differentiation associated protein 1
GLT8D2 glycosyltransferase 8 domain containing 2
GMEB1 glucocorticoid modulatory element binding protein 1
GTF2I general transcription factor IIi
H2BFS H2B histone family, member S (pseudogene)
HAGH hydroxyacylglutathione hydrolase
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HP1BP3 heterochromatin protein 1, binding protein 3
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFI30 interferon, gamma-inducible protein 30
IFI6 interferon, alpha-inducible protein 6
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
INF2 inverted formin, FH2 and WH2 domain containing
IPO8 importin 8
KDM5C lysine (K)-specific demethylase 5C
KLF13 Kruppel-like factor 13
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LY6E lymphocyte antigen 6 complex, locus E
MBTPS2 membrane-bound transcription factor peptidase, site 2
MCRS1 microspherule protein 1
MECR mitochondrial trans-2-enoyl-CoA reductase
MITF microphthalmia-associated transcription factor
MPDU1 mannose-P-dolichol utilization defect 1
MT1HL1 metallothionein 1H-like 1
MXD3 MAX dimerization protein 3
NEDD8 neural precursor cell expressed, developmentally down-regulated 8
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NUPR1 nuclear protein, transcriptional regulator, 1
NUS1P3 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) pseudogene 3
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PAIP2B poly(A) binding protein interacting protein 2B
PARM1 prostate androgen-regulated mucin-like protein 1
PDCD5 programmed cell death 5
PDE8B phosphodiesterase 8B
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PGD phosphogluconate dehydrogenase
PLEKHO1 pleckstrin homology domain containing, family O member 1
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit
POLM polymerase (DNA directed), mu
POLR2F polymerase (RNA) II (DNA directed) polypeptide F
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
PTK7 protein tyrosine kinase 7 (inactive)
PWAR5 Prader Willi/Angelman region RNA 5
RNF146 ring finger protein 146
RPL11 ribosomal protein L11
SELT selenoprotein T
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2
SLPI secretory leukocyte peptidase inhibitor
STK16 serine/threonine kinase 16
SYNPO synaptopodin
SYTL2 synaptotagmin-like 2
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
THRAP3 thyroid hormone receptor associated protein 3
TRAPPC2L trafficking protein particle complex 2-like
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TSPAN1 tetraspanin 1
ULBP2 UL16 binding protein 2
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X
USP18 ubiquitin specific peptidase 18
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
ZMAT5 zinc finger, matrin-type 5
ZNHIT1 zinc finger, HIT-type containing 1
ZNHIT2 zinc finger, HIT-type containing 2