aminocaproic acid-3122 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the aminocaproic acid-3122 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTC1 actin, alpha, cardiac muscle 1
AIF1 allograft inflammatory factor 1
AKAP8L A kinase (PRKA) anchor protein 8-like
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
ALDOB aldolase B, fructose-bisphosphate
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
ARHGAP35 Rho GTPase activating protein 35
ART1 ADP-ribosyltransferase 1
ATN1 atrophin 1
BAGE B melanoma antigen
BAIAP2 BAI1-associated protein 2
BLK BLK proto-oncogene, Src family tyrosine kinase
CA1 carbonic anhydrase I
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CACNB2 calcium channel, voltage-dependent, beta 2 subunit
CALD1 caldesmon 1
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CLCF1 cardiotrophin-like cytokine factor 1
CNTNAP1 contactin associated protein 1
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
DMP1 dentin matrix acidic phosphoprotein 1
ENDOD1 endonuclease domain containing 1
ENG endoglin
ERC2-IT1 ERC2 intronic transcript 1
ESR1 estrogen receptor 1
EXT1 exostosin glycosyltransferase 1
FAM76A family with sequence similarity 76, member A
FBXL2 F-box and leucine-rich repeat protein 2
FGB fibrinogen beta chain
FGFR1 fibroblast growth factor receptor 1
FN1 fibronectin 1
FOSL2 FOS-like antigen 2
FYB FYN binding protein
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GAS8 growth arrest-specific 8
GNG3 guanine nucleotide binding protein (G protein), gamma 3
HDAC7 histone deacetylase 7
HIST1H2BM histone cluster 1, H2bm
IDUA iduronidase, alpha-L-
IFITM1 interferon induced transmembrane protein 1
IL21R interleukin 21 receptor
IL7R interleukin 7 receptor
JAM3 junctional adhesion molecule 3
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KLF3 Kruppel-like factor 3 (basic)
KLHL18 kelch-like family member 18
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
METTL7A methyltransferase like 7A
MKRN3 makorin ring finger protein 3
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
MPDZ multiple PDZ domain protein
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MUC8 mucin 8
NBL1 neuroblastoma 1, DAN family BMP antagonist
NCKIPSD NCK interacting protein with SH3 domain
NPPA natriuretic peptide A
NPTXR neuronal pentraxin receptor
NRCAM neuronal cell adhesion molecule
NTNG1 netrin G1
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM1 olfactomedin 1
PCSK6 proprotein convertase subtilisin/kexin type 6
PDE4DIP phosphodiesterase 4D interacting protein
PLCH1 phospholipase C, eta 1
PLXNA1 plexin A1
PQLC2 PQ loop repeat containing 2
PRY PTPN13-like, Y-linked
QTRT1 queuine tRNA-ribosyltransferase 1
RECQL5 RecQ protein-like 5
RETN resistin
RGS3 regulator of G-protein signaling 3
RIPPLY3 ripply transcriptional repressor 3
RUNX2 runt-related transcription factor 2
SCHIP1 schwannomin interacting protein 1
SH2D4A SH2 domain containing 4A
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SORCS3 sortilin-related VPS10 domain containing receptor 3
SOX15 SRY (sex determining region Y)-box 15
SPPL2B signal peptide peptidase like 2B
SRR serine racemase
STAB2 stabilin 2
STAT5B signal transducer and activator of transcription 5B
STX2 syntaxin 2
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
SULT4A1 sulfotransferase family 4A, member 1
TEF thyrotrophic embryonic factor
THAP9 THAP domain containing 9
TPH1 tryptophan hydroxylase 1
TRIM62 tripartite motif containing 62
UNC45A unc-45 homolog A (C. elegans)
VASH2 vasohibin 2
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZNF276 zinc finger protein 276
ZNF280A zinc finger protein 280A
ZNF3 zinc finger protein 3
ZNF688 zinc finger protein 688
ZNF696 zinc finger protein 696

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ACOX2 acyl-CoA oxidase 2, branched chain
ADAM15 ADAM metallopeptidase domain 15
ADGRE1 adhesion G protein-coupled receptor E1
ADORA3 adenosine A3 receptor
AMT aminomethyltransferase
BEST1 bestrophin 1
C14ORF93 chromosome 14 open reading frame 93
C7ORF43 chromosome 7 open reading frame 43
CBX4 chromobox homolog 4
CDR2L cerebellar degeneration-related protein 2-like
CENPO centromere protein O
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
CHST10 carbohydrate sulfotransferase 10
CLEC4E C-type lectin domain family 4, member E
CLPTM1 cleft lip and palate associated transmembrane protein 1
CNTN1 contactin 1
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
DENND1A DENN/MADD domain containing 1A
DENND4C DENN/MADD domain containing 4C
DGKG diacylglycerol kinase, gamma 90kDa
DYSF dysferlin
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FBXL6 F-box and leucine-rich repeat protein 6
FGF22 fibroblast growth factor 22
FHL3 four and a half LIM domains 3
GCH1 GTP cyclohydrolase 1
GPRASP1 G protein-coupled receptor associated sorting protein 1
GRIP2 glutamate receptor interacting protein 2
GSTM2 glutathione S-transferase mu 2 (muscle)
HECTD3 HECT domain containing E3 ubiquitin protein ligase 3
HIST1H1T histone cluster 1, H1t
HIST1H4D histone cluster 1, H4d
HOXA5 homeobox A5
IDI2-AS1 IDI2 antisense RNA 1
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
JAM2 junctional adhesion molecule 2
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KIF13B kinesin family member 13B
LIMD2 LIM domain containing 2
LNPEP leucyl/cystinyl aminopeptidase
LY6E lymphocyte antigen 6 complex, locus E
LYPLA2P1 lysophospholipase II pseudogene 1
MLPH melanophilin
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MYH15 myosin, heavy chain 15
NT5DC3 5'-nucleotidase domain containing 3
NXPH4 neurexophilin 4
PCDHGA10 protocadherin gamma subfamily A, 10
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PIGH phosphatidylinositol glycan anchor biosynthesis, class H
PIP prolactin-induced protein
PLCL1 phospholipase C-like 1
PPDPF pancreatic progenitor cell differentiation and proliferation factor
PRDM1 PR domain containing 1, with ZNF domain
PRKCZ protein kinase C, zeta
PTDSS2 phosphatidylserine synthase 2
PYGB phosphorylase, glycogen; brain
RAB13 RAB13, member RAS oncogene family
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RASAL1 RAS protein activator like 1 (GAP1 like)
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RHOBTB2 Rho-related BTB domain containing 2
RNF121 ring finger protein 121
RPAP1 RNA polymerase II associated protein 1
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
SCN10A sodium channel, voltage gated, type X alpha subunit
SIPA1L1 signal-induced proliferation-associated 1 like 1
SLC12A8 solute carrier family 12, member 8
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC2A4RG SLC2A4 regulator
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
ST7L suppression of tumorigenicity 7 like
STBD1 starch binding domain 1
TAS2R10 taste receptor, type 2, member 10
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TMEM212 transmembrane protein 212
TRAF1 TNF receptor-associated factor 1
TRAF2 TNF receptor-associated factor 2
TSPAN13 tetraspanin 13
TTC23 tetratricopeptide repeat domain 23
TTC4 tetratricopeptide repeat domain 4
USP18 ubiquitin specific peptidase 18
VSIG10 V-set and immunoglobulin domain containing 10
XKR8 XK, Kell blood group complex subunit-related family, member 8
ZBTB38 zinc finger and BTB domain containing 38
ZNF155 zinc finger protein 155
ZNF177 zinc finger protein 177
ZNF34 zinc finger protein 34
ZNF408 zinc finger protein 408
ZNF76 zinc finger protein 76