aminocaproic acid-6501 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the aminocaproic acid-6501 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
AGMAT agmatine ureohydrolase (agmatinase)
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
ALOXE3 arachidonate lipoxygenase 3
ARMC4 armadillo repeat containing 4
ART1 ADP-ribosyltransferase 1
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BAIAP3 BAI1-associated protein 3
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
C19ORF26 chromosome 19 open reading frame 26
C21ORF2 chromosome 21 open reading frame 2
C7ORF69 chromosome 7 open reading frame 69
CABIN1 calcineurin binding protein 1
CCNJL cyclin J-like
CCRL2 chemokine (C-C motif) receptor-like 2
CDADC1 cytidine and dCMP deaminase domain containing 1
CLCA4 chloride channel accessory 4
CNN3 calponin 3, acidic
COL6A1 collagen, type VI, alpha 1
COL9A3 collagen, type IX, alpha 3
CTRL chymotrypsin-like
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2
DGCR2 DiGeorge syndrome critical region gene 2
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DSG3 desmoglein 3
EGR4 early growth response 4
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
ERCC2 excision repair cross-complementation group 2
FABP3 fatty acid binding protein 3, muscle and heart
FOXF1 forkhead box F1
FRMD4B FERM domain containing 4B
GJA8 gap junction protein, alpha 8, 50kDa
GMPR guanosine monophosphate reductase
GUCY1A2 guanylate cyclase 1, soluble, alpha 2
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
HFE hemochromatosis
IBA57 IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)
ICAM1 intercellular adhesion molecule 1
ICOS inducible T-cell co-stimulator
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL11 interleukin 11
ITGB7 integrin, beta 7
KLHL22 kelch-like family member 22
KRT17 keratin 17, type I
L3MBTL1 l(3)mbt-like 1 (Drosophila)
LAMA4 laminin, alpha 4
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
MAPK7 mitogen-activated protein kinase 7
MARK4 MAP/microtubule affinity-regulating kinase 4
MBNL2 muscleblind-like splicing regulator 2
MMP11 matrix metallopeptidase 11
MYL4 myosin, light chain 4, alkali; atrial, embryonic
MYLK myosin light chain kinase
NOD1 nucleotide-binding oligomerization domain containing 1
NRP2 neuropilin 2
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
OSMR oncostatin M receptor
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4
POLL polymerase (DNA directed), lambda
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTX3 pentraxin 3, long
RBBP9 retinoblastoma binding protein 9
RBM12B RNA binding motif protein 12B
RCAN1 regulator of calcineurin 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS12 regulator of G-protein signaling 12
RPS4Y1 ribosomal protein S4, Y-linked 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC30A3 solute carrier family 30 (zinc transporter), member 3
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC44A1 solute carrier family 44 (choline transporter), member 1
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SMTN smoothelin
SORBS1 sorbin and SH3 domain containing 1
SP1 Sp1 transcription factor
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STX7 syntaxin 7
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TMEM259 transmembrane protein 259
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TREM2 triggering receptor expressed on myeloid cells 2
TSHR thyroid stimulating hormone receptor
TUBA3C tubulin, alpha 3c
USP46 ubiquitin specific peptidase 46
WDR91 WD repeat domain 91
WIPI2 WD repeat domain, phosphoinositide interacting 2
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
ZNF277 zinc finger protein 277
ZNF318 zinc finger protein 318
ZNF358 zinc finger protein 358
ZNF506 zinc finger protein 506

decreased expression

Symbol Name
ACADSB acyl-CoA dehydrogenase, short/branched chain
ADGRL2 adhesion G protein-coupled receptor L2
AMT aminomethyltransferase
APLP1 amyloid beta (A4) precursor-like protein 1
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BBC3 BCL2 binding component 3
BRIP1 BRCA1 interacting protein C-terminal helicase 1
BRPF1 bromodomain and PHD finger containing, 1
CAPRIN2 caprin family member 2
CCDC132 coiled-coil domain containing 132
CCP110 centriolar coiled coil protein 110kDa
CD2AP CD2-associated protein
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DBR1 debranching RNA lariats 1
DDIT3 DNA-damage-inducible transcript 3
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DENND4A DENN/MADD domain containing 4A
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DOCK1 dedicator of cytokinesis 1
DSCAM Down syndrome cell adhesion molecule
EAF2 ELL associated factor 2
ENO2 enolase 2 (gamma, neuronal)
EPHA2 EPH receptor A2
EVPL envoplakin
FAM118A family with sequence similarity 118, member A
FAM204A family with sequence similarity 204, member A
FBXL6 F-box and leucine-rich repeat protein 6
FURIN furin (paired basic amino acid cleaving enzyme)
GATA4 GATA binding protein 4
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPR87 G protein-coupled receptor 87
GPX2 glutathione peroxidase 2
GUSBP3 glucuronidase, beta pseudogene 3
HIST1H2AJ histone cluster 1, H2aj
HOXA4 homeobox A4
IRF1 interferon regulatory factor 1
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KIAA0125 KIAA0125
KLF11 Kruppel-like factor 11
LRRC8E leucine rich repeat containing 8 family, member E
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1
MANBA mannosidase, beta A, lysosomal
MAP9 microtubule-associated protein 9
MBTD1 mbt domain containing 1
METTL16 methyltransferase like 16
MITF microphthalmia-associated transcription factor
NNT nicotinamide nucleotide transhydrogenase
NXPH4 neurexophilin 4
OLFML2A olfactomedin-like 2A
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PADI1 peptidyl arginine deiminase, type I
PER3 period circadian clock 3
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PRMT7 protein arginine methyltransferase 7
PROS1 protein S (alpha)
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
RPGR retinitis pigmentosa GTPase regulator
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SAMHD1 SAM domain and HD domain 1
SAV1 salvador family WW domain containing protein 1
SCYL2 SCY1-like 2 (S. cerevisiae)
SHARPIN SHANK-associated RH domain interactor
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2
STAG3L1 stromal antigen 3-like 1 (pseudogene)
SYCP2 synaptonemal complex protein 2
SYNC syncoilin, intermediate filament protein
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TBX19 T-box 19
TCTN1 tectonic family member 1
TET3 tet methylcytosine dioxygenase 3
THBS3 thrombospondin 3
TMC5 transmembrane channel-like 5
TNS2 tensin 2
TRDMT1 tRNA aspartic acid methyltransferase 1
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TTBK2 tau tubulin kinase 2
TTC28 tetratricopeptide repeat domain 28
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
XAB2 XPA binding protein 2
XYLT2 xylosyltransferase II
ZNF10 zinc finger protein 10
ZNF428 zinc finger protein 428
ZNF611 zinc finger protein 611
ZNF747 zinc finger protein 747