aminocaproic acid-7258 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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193 genes differentially expressed following the aminocaproic acid-7258 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTR3B ARP3 actin-related protein 3 homolog B (yeast)
ALDOAP2 aldolase A, fructose-bisphosphate pseudogene 2
ARC activity-regulated cytoskeleton-associated protein
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
ATXN2L ataxin 2-like
BDH1 3-hydroxybutyrate dehydrogenase, type 1
C22ORF46 chromosome 22 open reading frame 46
C9ORF40 chromosome 9 open reading frame 40
CA11 carbonic anhydrase XI
CABIN1 calcineurin binding protein 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP5 caspase 5, apoptosis-related cysteine peptidase
CAV2 caveolin 2
CFLAR CASP8 and FADD-like apoptosis regulator
CLDN11 claudin 11
COL6A1 collagen, type VI, alpha 1
CPEB1 cytoplasmic polyadenylation element binding protein 1
CPT1A carnitine palmitoyltransferase 1A (liver)
CSHL1 chorionic somatomammotropin hormone-like 1
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
CXCL3 chemokine (C-X-C motif) ligand 3
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DNPEP aspartyl aminopeptidase
DSPP dentin sialophosphoprotein
DTX2 deltex 2, E3 ubiquitin ligase
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
FKBP8 FK506 binding protein 8, 38kDa
GABARAPL3 GABA(A) receptors associated protein like 3, pseudogene
GSK3A glycogen synthase kinase 3 alpha
GTDC1 glycosyltransferase-like domain containing 1
HABP4 hyaluronan binding protein 4
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSDL2 hydroxysteroid dehydrogenase like 2
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
INSR insulin receptor
IRF1 interferon regulatory factor 1
KIF5C kinesin family member 5C
KLHL22 kelch-like family member 22
LPCAT4 lysophosphatidylcholine acyltransferase 4
MAP7 microtubule-associated protein 7
MARS methionyl-tRNA synthetase
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MLH3 mutL homolog 3
MTSS1L metastasis suppressor 1-like
MUC1 mucin 1, cell surface associated
MYH15 myosin, heavy chain 15
MYO9B myosin IXB
MYRF myelin regulatory factor
N4BP1 NEDD4 binding protein 1
NACA2 nascent polypeptide-associated complex alpha subunit 2
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa
NF2 neurofibromin 2 (merlin)
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NID2 nidogen 2 (osteonidogen)
NOTCH3 notch 3
NRXN3 neurexin 3
NTSR1 neurotensin receptor 1 (high affinity)
PALM paralemmin
PLA2G15 phospholipase A2, group XV
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
RREB1 ras responsive element binding protein 1
RUNX3 runt-related transcription factor 3
RWDD2A RWD domain containing 2A
SCARB1 scavenger receptor class B, member 1
SFTPB surfactant protein B
SGSM3 small G protein signaling modulator 3
SIPA1L3 signal-induced proliferation-associated 1 like 3
SKIL SKI-like proto-oncogene
SLC26A6 solute carrier family 26 (anion exchanger), member 6
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa
SOGA1 suppressor of glucose, autophagy associated 1
ST6GALNAC4 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
SUGCT succinyl-CoA:glutarate-CoA transferase
SZT2 seizure threshold 2 homolog (mouse)
TBC1D5 TBC1 domain family, member 5
TMEM231 transmembrane protein 231
TNC tenascin C
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
UBQLN4 ubiquilin 4
UNC45A unc-45 homolog A (C. elegans)
UROD uroporphyrinogen decarboxylase
USP20 ubiquitin specific peptidase 20
VCAN versican
WWOX WW domain containing oxidoreductase
ZNF408 zinc finger protein 408
ZNF675 zinc finger protein 675
ZNF783 zinc finger family member 783

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ACYP1 acylphosphatase 1, erythrocyte (common) type
ANKFY1 ankyrin repeat and FYVE domain containing 1
AP1G2 adaptor-related protein complex 1, gamma 2 subunit
AUH AU RNA binding protein/enoyl-CoA hydratase
BRIP1 BRCA1 interacting protein C-terminal helicase 1
BRIX1 BRX1, biogenesis of ribosomes
C8ORF60 chromosome 8 open reading frame 60
CADPS2 Ca++-dependent secretion activator 2
CAPN5 calpain 5
CLEC16A C-type lectin domain family 16, member A
CTAGE9 CTAGE family, member 9
CTNNBL1 catenin, beta like 1
CUL9 cullin 9
DET1 de-etiolated homolog 1 (Arabidopsis)
DHRS3 dehydrogenase/reductase (SDR family) member 3
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DTWD1 DTW domain containing 1
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
ELAVL2 ELAV like neuron-specific RNA binding protein 2
ERAL1 Era-like 12S mitochondrial rRNA chaperone 1
ERCC5 excision repair cross-complementation group 5
EXOC5 exocyst complex component 5
F8 coagulation factor VIII, procoagulant component
FAM172A family with sequence similarity 172, member A
FAM179B family with sequence similarity 179, member B
FBXL2 F-box and leucine-rich repeat protein 2
FBXO46 F-box protein 46
GAB2 GRB2-associated binding protein 2
GPHN gephyrin
GUF1 GUF1 GTPase homolog (S. cerevisiae)
HIRA histone cell cycle regulator
HIST1H2AG histone cluster 1, H2ag
HLA-J major histocompatibility complex, class I, J (pseudogene)
HYAL2 hyaluronoglucosaminidase 2
IL7R interleukin 7 receptor
ISL1 ISL LIM homeobox 1
JUNB jun B proto-oncogene
KIAA1462 KIAA1462
KPTN kaptin (actin binding protein)
LPAR6 lysophosphatidic acid receptor 6
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2
LRRC49 leucine rich repeat containing 49
MAN2B2 mannosidase, alpha, class 2B, member 2
MINPP1 multiple inositol-polyphosphate phosphatase 1
MPP1 membrane protein, palmitoylated 1, 55kDa
MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
MTMR11 myotubularin related protein 11
MUL1 mitochondrial E3 ubiquitin protein ligase 1
NAP1L3 nucleosome assembly protein 1-like 3
NMB neuromedin B
NME3 NME/NM23 nucleoside diphosphate kinase 3
NME6 NME/NM23 nucleoside diphosphate kinase 6
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
POLR1B polymerase (RNA) I polypeptide B, 128kDa
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
QTRT1 queuine tRNA-ribosyltransferase 1
RBL1 retinoblastoma-like 1
RCL1 RNA terminal phosphate cyclase-like 1
RCOR3 REST corepressor 3
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RNF121 ring finger protein 121
RNF170 ring finger protein 170
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2
SERINC5 serine incorporator 5
SH2B3 SH2B adaptor protein 3
SLC22A18 solute carrier family 22, member 18
SLC25A40 solute carrier family 25, member 40
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SND1-IT1 SND1 intronic transcript 1
SNX24 sorting nexin 24
SOBP sine oculis binding protein homolog (Drosophila)
STARD13 StAR-related lipid transfer (START) domain containing 13
TASP1 taspase, threonine aspartase, 1
TBC1D17 TBC1 domain family, member 17
TBL3 transducin (beta)-like 3
TGDS TDP-glucose 4,6-dehydratase
TMEM177 transmembrane protein 177
TMEM38B transmembrane protein 38B
TNS2 tensin 2
TPST1 tyrosylprotein sulfotransferase 1
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TTF2 transcription termination factor, RNA polymerase II
TTI2 TELO2 interacting protein 2
TULP4 tubby like protein 4
USB1 U6 snRNA biogenesis 1
USPL1 ubiquitin specific peptidase like 1
YEATS4 YEATS domain containing 4
ZDHHC11 zinc finger, DHHC-type containing 11
ZNF107 zinc finger protein 107
ZNF232 zinc finger protein 232
ZNF562 zinc finger protein 562
ZNF862 zinc finger protein 862