aminophenazone-1376 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the aminophenazone-1376 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
AGRP agouti related neuropeptide
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
ARID5A AT rich interactive domain 5A (MRF1-like)
ARR3 arrestin 3, retinal (X-arrestin)
ASMTL acetylserotonin O-methyltransferase-like
ATG5 autophagy related 5
ATN1 atrophin 1
C21ORF2 chromosome 21 open reading frame 2
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CHKA choline kinase alpha
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKB creatine kinase, brain
CLCN6 chloride channel, voltage-sensitive 6
CLSPN claspin
COMT catechol-O-methyltransferase
CYB561 cytochrome b561
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6
DCN decorin
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DOPEY2 dopey family member 2
EDC3 enhancer of mRNA decapping 3
ELF2 E74-like factor 2 (ets domain transcription factor)
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FAM178A family with sequence similarity 178, member A
FBXL15 F-box and leucine-rich repeat protein 15
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
FMNL1 formin-like 1
GCAT glycine C-acetyltransferase
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GPSM3 G-protein signaling modulator 3
H2AFY H2A histone family, member Y
HIGD2A HIG1 hypoxia inducible domain family, member 2A
HINFP histone H4 transcription factor
HIST1H4C histone cluster 1, H4c
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
HOXA11 homeobox A11
ICAM1 intercellular adhesion molecule 1
IL6ST interleukin 6 signal transducer
KRI1 KRI1 homolog (S. cerevisiae)
LHB luteinizing hormone beta polypeptide
LIN7C lin-7 homolog C (C. elegans)
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LYST lysosomal trafficking regulator
METTL13 methyltransferase like 13
MFSD12 major facilitator superfamily domain containing 12
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1
MOCS2 molybdenum cofactor synthesis 2
MST1 macrophage stimulating 1
NCR2 natural cytotoxicity triggering receptor 2
NINJ2 ninjurin 2
NIPBL Nipped-B homolog (Drosophila)
NRP1 neuropilin 1
NSUN5P2 NOP2/Sun domain family, member 5 pseudogene 2
NT5DC2 5'-nucleotidase domain containing 2
NUDT2 nudix (nucleoside diphosphate linked moiety X)-type motif 2
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PAX1 paired box 1
PBX2 pre-B-cell leukemia homeobox 2
PCSK7 proprotein convertase subtilisin/kexin type 7
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDS5B PDS5 cohesin associated factor B
PECAM1 platelet/endothelial cell adhesion molecule 1
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
PTGES prostaglandin E synthase
QTRT1 queuine tRNA-ribosyltransferase 1
RANBP10 RAN binding protein 10
RASSF4 Ras association (RalGDS/AF-6) domain family member 4
RBM48 RNA binding motif protein 48
RHOQ ras homolog family member Q
RHOT1 ras homolog family member T1
RPP40 ribonuclease P/MRP 40kDa subunit
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SENP3 SUMO1/sentrin/SMT3 specific peptidase 3
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16
SMAD3 SMAD family member 3
SMG5 SMG5 nonsense mediated mRNA decay factor
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SPIDR scaffolding protein involved in DNA repair
SPPL2B signal peptide peptidase like 2B
SRSF11 serine/arginine-rich splicing factor 11
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae)
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TMEM143 transmembrane protein 143
TMEM63A transmembrane protein 63A
TMPO thymopoietin
TRADD TNFRSF1A-associated via death domain
VASP vasodilator-stimulated phosphoprotein
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
ZBTB40 zinc finger and BTB domain containing 40
ZC3H13 zinc finger CCCH-type containing 13
ZNF133 zinc finger protein 133
ZNF688 zinc finger protein 688
ZSWIM8 zinc finger, SWIM-type containing 8

decreased expression

Symbol Name
ABHD3 abhydrolase domain containing 3
ACOT8 acyl-CoA thioesterase 8
ACTR6 ARP6 actin-related protein 6 homolog (yeast)
ADRB2 adrenoceptor beta 2, surface
ALPK1 alpha-kinase 1
APOC4 apolipoprotein C-IV
AQP2 aquaporin 2 (collecting duct)
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
ASCC1 activating signal cointegrator 1 complex subunit 1
BRCA1 breast cancer 1, early onset
BTNL3 butyrophilin-like 3
C1ORF216 chromosome 1 open reading frame 216
CA7 carbonic anhydrase VII
CCDC176 coiled-coil domain containing 176
CD2AP CD2-associated protein
CD302 CD302 molecule
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
COMMD10 COMM domain containing 10
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CUEDC2 CUE domain containing 2
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1
ERCC8 excision repair cross-complementation group 8
FAF1 Fas (TNFRSF6) associated factor 1
FAM114A2 family with sequence similarity 114, member A2
FAM172A family with sequence similarity 172, member A
FGF4 fibroblast growth factor 4
FRG1 FSHD region gene 1
GCA grancalcin, EF-hand calcium binding protein
GDF9 growth differentiation factor 9
GNG3 guanine nucleotide binding protein (G protein), gamma 3
GTPBP3 GTP binding protein 3 (mitochondrial)
HDAC9 histone deacetylase 9
HIST1H2BK histone cluster 1, H2bk
HIST3H2A histone cluster 3, H2a
HMGN3 high mobility group nucleosomal binding domain 3
HSPA14 heat shock 70kDa protein 14
ISG15 ISG15 ubiquitin-like modifier
ITGAV integrin, alpha V
ITPKC inositol-trisphosphate 3-kinase C
KCTD3 potassium channel tetramerization domain containing 3
LBR lamin B receptor
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2
LRRC42 leucine rich repeat containing 42
MAGEF1 melanoma antigen family F1
MCM10 minichromosome maintenance complex component 10
MGLL monoglyceride lipase
MICB MHC class I polypeptide-related sequence B
MRGBP MRG/MORF4L binding protein
MUC3A mucin 3A, cell surface associated
MUL1 mitochondrial E3 ubiquitin protein ligase 1
NHEJ1 nonhomologous end-joining factor 1
NRIP3 nuclear receptor interacting protein 3
NUBP1 nucleotide binding protein 1
PADI1 peptidyl arginine deiminase, type I
PAK1IP1 PAK1 interacting protein 1
PDLIM2 PDZ and LIM domain 2 (mystique)
PELI2 pellino E3 ubiquitin protein ligase family member 2
PIP4K2C phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
PRDX3 peroxiredoxin 3
PRR3 proline rich 3
RBM15B RNA binding motif protein 15B
RBM47 RNA binding motif protein 47
RBM6 RNA binding motif protein 6
RBMS3 RNA binding motif, single stranded interacting protein 3
RDH14 retinol dehydrogenase 14 (all-trans/9-cis/11-cis)
RFWD3 ring finger and WD repeat domain 3
RNF123 ring finger protein 123
RNF146 ring finger protein 146
RPRD2 regulation of nuclear pre-mRNA domain containing 2
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2
RWDD3 RWD domain containing 3
SH3GL1 SH3-domain GRB2-like 1
SLC39A1 solute carrier family 39 (zinc transporter), member 1
SREK1 splicing regulatory glutamine/lysine-rich protein 1
STAC SH3 and cysteine rich domain
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative)
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast)
TM7SF3 transmembrane 7 superfamily member 3
TMEM135 transmembrane protein 135
TMEM184B transmembrane protein 184B
TMEM53 transmembrane protein 53
TMPRSS6 transmembrane protease, serine 6
TRAPPC11 trafficking protein particle complex 11
TSC22D1 TSC22 domain family, member 1
TSEN34 TSEN34 tRNA splicing endonuclease subunit
TSPAN14 tetraspanin 14
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene)
UNC13B unc-13 homolog B (C. elegans)
USP20 ubiquitin specific peptidase 20
UTP11L UTP11-like, U3 small nucleolar ribonucleoprotein (yeast)
WDR7 WD repeat domain 7
WT1-AS WT1 antisense RNA
WWP2 WW domain containing E3 ubiquitin protein ligase 2
ZCCHC8 zinc finger, CCHC domain containing 8
ZNF140 zinc finger protein 140