aminophylline-5395 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the aminophylline-5395 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADRA1D adrenoceptor alpha 1D
AKR1C4 aldo-keto reductase family 1, member C4
ALDOB aldolase B, fructose-bisphosphate
AQP3 aquaporin 3 (Gill blood group)
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide
BEGAIN brain-enriched guanylate kinase-associated
C17ORF59 chromosome 17 open reading frame 59
C19ORF66 chromosome 19 open reading frame 66
CALML5 calmodulin-like 5
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CCHCR1 coiled-coil alpha-helical rod protein 1
CCR4 chemokine (C-C motif) receptor 4
CDC42 cell division cycle 42
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CGA glycoprotein hormones, alpha polypeptide
CHN2 chimerin 2
CLEC10A C-type lectin domain family 10, member A
CLMN calmin (calponin-like, transmembrane)
COL1A1 collagen, type I, alpha 1
CORO7 coronin 7
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
DCN decorin
DFNB31 deafness, autosomal recessive 31
DOK5 docking protein 5
DTNA dystrobrevin, alpha
EGR3 early growth response 3
EML2 echinoderm microtubule associated protein like 2
EXOC6B exocyst complex component 6B
EYA3 EYA transcriptional coactivator and phosphatase 3
FAM186A family with sequence similarity 186, member A
FANCA Fanconi anemia, complementation group A
FBXL7 F-box and leucine-rich repeat protein 7
FCN3 ficolin (collagen/fibrinogen domain containing) 3
FRAS1 Fraser extracellular matrix complex subunit 1
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GLRA3 glycine receptor, alpha 3
GSPT2 G1 to S phase transition 2
HBS1L HBS1-like translational GTPase
HFE hemochromatosis
HIST1H1T histone cluster 1, H1t
HNF1B HNF1 homeobox B
HRH2 histamine receptor H2
HSF4 heat shock transcription factor 4
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
ITGA10 integrin, alpha 10
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KLHL25 kelch-like family member 25
KMT2A lysine (K)-specific methyltransferase 2A
LAT2 linker for activation of T cells family, member 2
LPCAT4 lysophosphatidylcholine acyltransferase 4
LTBP4 latent transforming growth factor beta binding protein 4
LUZP4 leucine zipper protein 4
MAPK10 mitogen-activated protein kinase 10
MBD3 methyl-CpG binding domain protein 3
MID1 midline 1
MMP25 matrix metallopeptidase 25
MMP3 matrix metallopeptidase 3
MTCP1 mature T-cell proliferation 1
MTRF1L mitochondrial translational release factor 1-like
NADK NAD kinase
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
PARVA parvin, alpha
PCSK6 proprotein convertase subtilisin/kexin type 6
PKNOX2 PBX/knotted 1 homeobox 2
PMEL premelanosome protein
PMFBP1 polyamine modulated factor 1 binding protein 1
PRB1 proline-rich protein BstNI subfamily 1
PROC protein C (inactivator of coagulation factors Va and VIIIa)
RBP4 retinol binding protein 4, plasma
RFPL1 ret finger protein-like 1
RIMS2 regulating synaptic membrane exocytosis 2
SCUBE3 signal peptide, CUB domain, EGF-like 3
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SHANK2 SH3 and multiple ankyrin repeat domains 2
SLC17A2 solute carrier family 17, member 2
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SPATS2L spermatogenesis associated, serine-rich 2-like
SPTBN1 spectrin, beta, non-erythrocytic 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
STK38L serine/threonine kinase 38 like
TAT tyrosine aminotransferase
TCF4 transcription factor 4
TNC tenascin C
TSC22D2 TSC22 domain family, member 2
VAMP5 vesicle-associated membrane protein 5
WDFY3 WD repeat and FYVE domain containing 3
WDR59 WD repeat domain 59
ZC4H2 zinc finger, C4H2 domain containing
ZFP36L2 ZFP36 ring finger protein-like 2
ZIC3 Zic family member 3
ZNF235 zinc finger protein 235
ZNF324 zinc finger protein 324

decreased expression

Symbol Name
AHDC1 AT hook, DNA binding motif, containing 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
BAG4 BCL2-associated athanogene 4
BMP4 bone morphogenetic protein 4
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2
BST2 bone marrow stromal cell antigen 2
C19ORF73 chromosome 19 open reading frame 73
C1QTNF3 C1q and tumor necrosis factor related protein 3
C5AR2 complement component 5a receptor 2
C5ORF45 chromosome 5 open reading frame 45
CEP97 centrosomal protein 97kDa
CES3 carboxylesterase 3
CHM choroideremia (Rab escort protein 1)
CLEC16A C-type lectin domain family 16, member A
CLGN calmegin
CLSPN claspin
CRY2 cryptochrome circadian clock 2
CRYBB2P1 crystallin, beta B2 pseudogene 1
CTSF cathepsin F
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae)
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
DOC2A double C2-like domains, alpha
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
EIF5A2 eukaryotic translation initiation factor 5A2
ERN2 endoplasmic reticulum to nucleus signaling 2
F2R coagulation factor II (thrombin) receptor
FAM114A2 family with sequence similarity 114, member A2
FAM46C family with sequence similarity 46, member C
FILIP1L filamin A interacting protein 1-like
FKBP10 FK506 binding protein 10, 65 kDa
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GAMT guanidinoacetate N-methyltransferase
GBP2 guanylate binding protein 2, interferon-inducible
GMPR guanosine monophosphate reductase
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPR143 G protein-coupled receptor 143
GRTP1 growth hormone regulated TBC protein 1
HDAC5 histone deacetylase 5
HIST1H3B histone cluster 1, H3b
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IQCG IQ motif containing G
IRF6 interferon regulatory factor 6
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KAT2A K(lysine) acetyltransferase 2A
LIN7A lin-7 homolog A (C. elegans)
LYPD1 LY6/PLAUR domain containing 1
MBNL3 muscleblind-like splicing regulator 3
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MDM4 MDM4, p53 regulator
MITF microphthalmia-associated transcription factor
MRPS18C mitochondrial ribosomal protein S18C
MTERF4 mitochondrial transcription termination factor 4
MYOZ3 myozenin 3
NPM3 nucleophosmin/nucleoplasmin 3
P3H1 prolyl 3-hydroxylase 1
PITX2 paired-like homeodomain 2
PLD2 phospholipase D2
PTPRU protein tyrosine phosphatase, receptor type, U
QSER1 glutamine and serine rich 1
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RIPK4 receptor-interacting serine-threonine kinase 4
RPL23AP32 ribosomal protein L23a pseudogene 32
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
RUNDC3B RUN domain containing 3B
SAYSD1 SAYSVFN motif domain containing 1
SLC25A40 solute carrier family 25, member 40
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SP1 Sp1 transcription factor
SPINK5 serine peptidase inhibitor, Kazal type 5
STAG3L4 stromal antigen 3-like 4 (pseudogene)
SYCP2 synaptonemal complex protein 2
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TBC1D17 TBC1 domain family, member 17
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TMEM209 transmembrane protein 209
TMUB2 transmembrane and ubiquitin-like domain containing 2
TRNAU1AP tRNA selenocysteine 1 associated protein 1
TTBK2 tau tubulin kinase 2
WDR62 WD repeat domain 62
WFDC2 WAP four-disulfide core domain 2
YIF1B Yip1 interacting factor homolog B (S. cerevisiae)
ZBTB39 zinc finger and BTB domain containing 39
ZBTB48 zinc finger and BTB domain containing 48
ZC3H3 zinc finger CCCH-type containing 3
ZNF10 zinc finger protein 10
ZNF205 zinc finger protein 205
ZNF253 zinc finger protein 253
ZNF35 zinc finger protein 35
ZNF480 zinc finger protein 480
ZNF574 zinc finger protein 574
ZNF675 zinc finger protein 675
ZNF747 zinc finger protein 747
ZNHIT2 zinc finger, HIT-type containing 2