aminophylline-6295 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the aminophylline-6295 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9
ACOT11 acyl-CoA thioesterase 11
ACSM1 acyl-CoA synthetase medium-chain family member 1
ACTN2 actinin, alpha 2
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12
ADCY6 adenylate cyclase 6
ADRBK2 adrenergic, beta, receptor kinase 2
AK5 adenylate kinase 5
ALK anaplastic lymphoma receptor tyrosine kinase
ALPPL2 alkaline phosphatase, placental-like 2
AMPH amphiphysin
APC adenomatous polyposis coli
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ASIC1 acid sensing (proton gated) ion channel 1
ASPHD1 aspartate beta-hydroxylase domain containing 1
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BCL2L10 BCL2-like 10 (apoptosis facilitator)
C5ORF42 chromosome 5 open reading frame 42
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CAPN5 calpain 5
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CFH complement factor H
CNGB3 cyclic nucleotide gated channel beta 3
CNTD2 cyclin N-terminal domain containing 2
COL1A2 collagen, type I, alpha 2
CORO2B coronin, actin binding protein, 2B
CSF1 colony stimulating factor 1 (macrophage)
CTNS cystinosin, lysosomal cystine transporter
CYP4F8 cytochrome P450, family 4, subfamily F, polypeptide 8
DENND2A DENN/MADD domain containing 2A
DEPTOR DEP domain containing MTOR-interacting protein
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17
DSTYK dual serine/threonine and tyrosine protein kinase
DUSP9 dual specificity phosphatase 9
EFNA3 ephrin-A3
ELAC2 elaC ribonuclease Z 2
EML3 echinoderm microtubule associated protein like 3
EPS8L1 EPS8-like 1
ESR1 estrogen receptor 1
FCMR Fc fragment of IgM receptor
GAS7 growth arrest-specific 7
GDPD2 glycerophosphodiester phosphodiesterase domain containing 2
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
IGHMBP2 immunoglobulin mu binding protein 2
IL2RB interleukin 2 receptor, beta
IRF4 interferon regulatory factor 4
KAZALD1 Kazal-type serine peptidase inhibitor domain 1
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KIFC3 kinesin family member C3
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
KRIT1 KRIT1, ankyrin repeat containing
KRT4 keratin 4, type II
KYNU kynureninase
LAIR2 leukocyte-associated immunoglobulin-like receptor 2
LINC00341 long intergenic non-protein coding RNA 341
LPAR4 lysophosphatidic acid receptor 4
LRRC61 leucine rich repeat containing 61
MANBA mannosidase, beta A, lysosomal
MAP3K9 mitogen-activated protein kinase kinase kinase 9
MARS methionyl-tRNA synthetase
MYL10 myosin, light chain 10, regulatory
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
NME5 NME/NM23 family member 5
NT5M 5',3'-nucleotidase, mitochondrial
OLFML2B olfactomedin-like 2B
PADI1 peptidyl arginine deiminase, type I
PBX2 pre-B-cell leukemia homeobox 2
PDE3B phosphodiesterase 3B, cGMP-inhibited
PLEKHO1 pleckstrin homology domain containing, family O member 1
PRDX2 peroxiredoxin 2
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PROL1 proline rich, lacrimal 1
PTPN14 protein tyrosine phosphatase, non-receptor type 14
PTPN21 protein tyrosine phosphatase, non-receptor type 21
RBM19 RNA binding motif protein 19
RHOBTB2 Rho-related BTB domain containing 2
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
SAFB scaffold attachment factor B
SBNO2 strawberry notch homolog 2 (Drosophila)
SCAPER S-phase cyclin A-associated protein in the ER
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2
SPN sialophorin
SPTB spectrin, beta, erythrocytic
SQSTM1 sequestosome 1
TESPA1 thymocyte expressed, positive selection associated 1
THOC5 THO complex 5
TMCC1 transmembrane and coiled-coil domain family 1
TOP3A topoisomerase (DNA) III alpha
TRAF3IP2 TRAF3 interacting protein 2
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
VWA5A von Willebrand factor A domain containing 5A
WDR1 WD repeat domain 1
WWOX WW domain containing oxidoreductase
ZNF227 zinc finger protein 227
ZNF771 zinc finger protein 771

decreased expression

Symbol Name
ADGRF1 adhesion G protein-coupled receptor F1
AEN apoptosis enhancing nuclease
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ARHGAP10 Rho GTPase activating protein 10
ARHGAP12 Rho GTPase activating protein 12
ATF7IP2 activating transcription factor 7 interacting protein 2
AUH AU RNA binding protein/enoyl-CoA hydratase
BAK1 BCL2-antagonist/killer 1
BCCIP BRCA2 and CDKN1A interacting protein
BGLAP bone gamma-carboxyglutamate (gla) protein
BHLHB9 basic helix-loop-helix domain containing, class B, 9
C1RL complement component 1, r subcomponent-like
CALCOCO1 calcium binding and coiled-coil domain 1
CCDC85C coiled-coil domain containing 85C
CCNJ cyclin J
CCNT1 cyclin T1
CCRL2 chemokine (C-C motif) receptor-like 2
CFAP44 cilia and flagella associated protein 44
CISH cytokine inducible SH2-containing protein
CRYBA2 crystallin, beta A2
CRYBB2P1 crystallin, beta B2 pseudogene 1
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DHRS7B dehydrogenase/reductase (SDR family) member 7B
DUSP8 dual specificity phosphatase 8
EIF5A2 eukaryotic translation initiation factor 5A2
EPPK1 epiplakin 1
FAM188A family with sequence similarity 188, member A
FCHSD2 FCH and double SH3 domains 2
FURIN furin (paired basic amino acid cleaving enzyme)
GJC1 gap junction protein, gamma 1, 45kDa
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPR176 G protein-coupled receptor 176
HIST1H2AJ histone cluster 1, H2aj
HIST1H2BI histone cluster 1, H2bi
HIST2H2AA3 histone cluster 2, H2aa3
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
IGFLR1 IGF-like family receptor 1
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
KIAA1462 KIAA1462
KLF2 Kruppel-like factor 2
LOC730101 uncharacterized LOC730101
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MAPK12 mitogen-activated protein kinase 12
MED15 mediator complex subunit 15
MUC7 mucin 7, secreted
MYL9 myosin, light chain 9, regulatory
MYO1E myosin IE
NPM3 nucleophosmin/nucleoplasmin 3
NSUN3 NOP2/Sun domain family, member 3
NUBP1 nucleotide binding protein 1
NXPE3 neurexophilin and PC-esterase domain family, member 3
ONECUT2 one cut homeobox 2
PALMD palmdelphin
PDGFRL platelet-derived growth factor receptor-like
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PDZD2 PDZ domain containing 2
PEX13 peroxisomal biogenesis factor 13
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PNRC1 proline-rich nuclear receptor coactivator 1
POGLUT1 protein O-glucosyltransferase 1
POM121 POM121 transmembrane nucleoporin
POR P450 (cytochrome) oxidoreductase
PRMT7 protein arginine methyltransferase 7
PRPH peripherin
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
RANGRF RAN guanine nucleotide release factor
REEP4 receptor accessory protein 4
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNF170 ring finger protein 170
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SCN1B sodium channel, voltage gated, type I beta subunit
SH3BGR SH3 domain binding glutamate-rich protein
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SLC35C2 solute carrier family 35 (GDP-fucose transporter), member C2
SNHG20 small nucleolar RNA host gene 20
STX17 syntaxin 17
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae)
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
TMEM132A transmembrane protein 132A
TMEM159 transmembrane protein 159
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TRNAU1AP tRNA selenocysteine 1 associated protein 1
TUBG2 tubulin, gamma 2
USB1 U6 snRNA biogenesis 1
USP6NL USP6 N-terminal like
WWC2 WW and C2 domain containing 2
ZFP36 ZFP36 ring finger protein
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF205 zinc finger protein 205
ZNF253 zinc finger protein 253
ZNF254 zinc finger protein 254
ZNF304 zinc finger protein 304
ZNF629 zinc finger protein 629
ZNF675 zinc finger protein 675