amiodarone-2434 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the amiodarone-2434 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTC1 actin, alpha, cardiac muscle 1
ACVR1B activin A receptor, type IB
ANKRD12 ankyrin repeat domain 12
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BIN1 bridging integrator 1
C11ORF16 chromosome 11 open reading frame 16
CAMP cathelicidin antimicrobial peptide
CCL24 chemokine (C-C motif) ligand 24
CD47 CD47 molecule
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CNTNAP1 contactin associated protein 1
COL6A1 collagen, type VI, alpha 1
CYB561 cytochrome b561
EIF1 eukaryotic translation initiation factor 1
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ETAA1 Ewing tumor-associated antigen 1
FAM135A family with sequence similarity 135, member A
FGF6 fibroblast growth factor 6
FGFR2 fibroblast growth factor receptor 2
FN1 fibronectin 1
FOXA1 forkhead box A1
GAS8 growth arrest-specific 8
GPM6B glycoprotein M6B
GPR137 G protein-coupled receptor 137
GPX3 glutathione peroxidase 3
GRIK5 glutamate receptor, ionotropic, kainate 5
HIST1H1D histone cluster 1, H1d
HOXC11 homeobox C11
ITGA8 integrin, alpha 8
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KANK1 KN motif and ankyrin repeat domains 1
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
KHSRP KH-type splicing regulatory protein
KIF5A kinesin family member 5A
KRT24 keratin 24, type I
KRT85 keratin 85, type II
LAMA4 laminin, alpha 4
LENEP lens epithelial protein
LMO1 LIM domain only 1 (rhombotin 1)
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
LRP2 low density lipoprotein receptor-related protein 2
MAP6D1 MAP6 domain containing 1
MBTD1 mbt domain containing 1
METTL16 methyltransferase like 16
MFAP3 microfibrillar-associated protein 3
MNMIP1 manchette microtubule inner protein 1
MORN1 MORN repeat containing 1
MYH14 myosin, heavy chain 14, non-muscle
N4BP2L2-IT2 N4BPL2 intronic transcript 2
NAG18 NAG18 mRNA
NCLN nicalin
NPC1 Niemann-Pick disease, type C1
NPY6R neuropeptide Y receptor Y6 (pseudogene)
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PAX2 paired box 2
PCDHGA8 protocadherin gamma subfamily A, 8
PCLO piccolo presynaptic cytomatrix protein
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLCD1 phospholipase C, delta 1
POU2F2 POU class 2 homeobox 2
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PRLH prolactin releasing hormone
RAB11B RAB11B, member RAS oncogene family
RAB13 RAB13, member RAS oncogene family
RPL10L ribosomal protein L10-like
S100A13 S100 calcium binding protein A13
SALL2 spalt-like transcription factor 2
SHOX2 short stature homeobox 2
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC45A2 solute carrier family 45, member 2
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SMAD5 SMAD family member 5
SOX2 SRY (sex determining region Y)-box 2
SPAG8 sperm associated antigen 8
SPDEF SAM pointed domain containing ETS transcription factor
SRR serine racemase
ST8SIA3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
STOML1 stomatin (EPB72)-like 1
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
SYNJ1 synaptojanin 1
SYNPO synaptopodin
TAS2R1 taste receptor, type 2, member 1
TBC1D2 TBC1 domain family, member 2
TFR2 transferrin receptor 2
TM4SF5 transmembrane 4 L six family member 5
TMEM212 transmembrane protein 212
TMEM63A transmembrane protein 63A
TP53I3 tumor protein p53 inducible protein 3
TRAF4 TNF receptor-associated factor 4
TRAF5 TNF receptor-associated factor 5
TRGV5 T cell receptor gamma variable 5
UBOX5 U-box domain containing 5
UTS2 urotensin 2
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
ZFP64 ZFP64 zinc finger protein
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF75D zinc finger protein 75D

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ADGRE1 adhesion G protein-coupled receptor E1
ANXA2P2 annexin A2 pseudogene 2
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
ARMC6 armadillo repeat containing 6
ASAP1-IT1 ASAP1 intronic transcript 1
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ATHL1 ATH1, acid trehalase-like 1 (yeast)
C2ORF44 chromosome 2 open reading frame 44
CCDC88C coiled-coil domain containing 88C
CCL4 chemokine (C-C motif) ligand 4
CDA cytidine deaminase
CDK3 cyclin-dependent kinase 3
CDK6 cyclin-dependent kinase 6
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
CES3 carboxylesterase 3
CHST10 carbohydrate sulfotransferase 10
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
CNTLN centlein, centrosomal protein
CPNE7 copine VII
CRELD1 cysteine-rich with EGF-like domains 1
CTNNBIP1 catenin, beta interacting protein 1
DEAF1 DEAF1 transcription factor
DGKG diacylglycerol kinase, gamma 90kDa
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DOK3 docking protein 3
DPEP2 dipeptidase 2
EMID1 EMI domain containing 1
EMILIN2 elastin microfibril interfacer 2
ERN2 endoplasmic reticulum to nucleus signaling 2
FBP1 fructose-1,6-bisphosphatase 1
FEM1C fem-1 homolog c (C. elegans)
FGF23 fibroblast growth factor 23
FGGY FGGY carbohydrate kinase domain containing
GCH1 GTP cyclohydrolase 1
GIPC1 GIPC PDZ domain containing family, member 1
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
GPHN gephyrin
GPR19 G protein-coupled receptor 19
GTF2IRD1 GTF2I repeat domain containing 1
HCFC2 host cell factor C2
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGSF6 immunoglobulin superfamily, member 6
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
KLHL28 kelch-like family member 28
KLHL36 kelch-like family member 36
LINS lines homolog (Drosophila)
LOC257152 uncharacterized LOC257152
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LY96 lymphocyte antigen 96
LZTS3 leucine zipper, putative tumor suppressor family member 3
MCTP2 multiple C2 domains, transmembrane 2
MIR22HG MIR22 host gene
MRPL28 mitochondrial ribosomal protein L28
NEUROD4 neuronal differentiation 4
NINJ2 ninjurin 2
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
P2RY11 purinergic receptor P2Y, G-protein coupled, 11
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PGP phosphoglycolate phosphatase
PIGH phosphatidylinositol glycan anchor biosynthesis, class H
PMCH pro-melanin-concentrating hormone
POLL polymerase (DNA directed), lambda
POR P450 (cytochrome) oxidoreductase
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E
PWAR5 Prader Willi/Angelman region RNA 5
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RRAS related RAS viral (r-ras) oncogene homolog
SFMBT1 Scm-like with four mbt domains 1
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SPATA1 spermatogenesis associated 1
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
STEAP3 STEAP family member 3, metalloreductase
STX11 syntaxin 11
TCTN2 tectonic family member 2
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TIGD6 tigger transposable element derived 6
TRAC T cell receptor alpha constant
TRANK1 tetratricopeptide repeat and ankyrin repeat containing 1
TSSC4 tumor suppressing subtransferable candidate 4
TTLL1 tubulin tyrosine ligase-like family member 1
UBQLN4 ubiquilin 4
UNC119 unc-119 homolog (C. elegans)
USB1 U6 snRNA biogenesis 1
VEGFC vascular endothelial growth factor C
VNN1 vanin 1
WDR33 WD repeat domain 33
ZNF134 zinc finger protein 134
ZNF137P zinc finger protein 137, pseudogene
ZNF197 zinc finger protein 197
ZNF32 zinc finger protein 32
ZNF428 zinc finger protein 428
ZNF76 zinc finger protein 76
ZSCAN16 zinc finger and SCAN domain containing 16