amiodarone-3296 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the amiodarone-3296 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACRV1 acrosomal vesicle protein 1
ATM ATM serine/threonine kinase
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BIRC7 baculoviral IAP repeat containing 7
BTF3P11 basic transcription factor 3 pseudogene 11
C19ORF73 chromosome 19 open reading frame 73
CD52 CD52 molecule
CD82 CD82 molecule
CDRT1 CMT1A duplicated region transcript 1
CFLAR CASP8 and FADD-like apoptosis regulator
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
CLCN6 chloride channel, voltage-sensitive 6
CNPPD1 cyclin Pas1/PHO80 domain containing 1
CPQ carboxypeptidase Q
CTNS cystinosin, lysosomal cystine transporter
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
F13A1 coagulation factor XIII, A1 polypeptide
FOXN3 forkhead box N3
FSCN1 fascin actin-bundling protein 1
GIPR gastric inhibitory polypeptide receptor
GM2A GM2 ganglioside activator
GNG13 guanine nucleotide binding protein (G protein), gamma 13
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
INHBE inhibin, beta E
IRS2 insulin receptor substrate 2
JUN jun proto-oncogene
KLHL24 kelch-like family member 24
KLHL25 kelch-like family member 25
KRTAP2-4 keratin associated protein 2-4
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LOC202181 SUMO-interacting motifs containing 1 pseudogene
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MED18 mediator complex subunit 18
MON2 MON2 homolog (S. cerevisiae)
MYOF myoferlin
NDE1 nudE neurodevelopment protein 1
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
NPY2R neuropeptide Y receptor Y2
NT5M 5',3'-nucleotidase, mitochondrial
NYNRIN NYN domain and retroviral integrase containing
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PCDHB12 protocadherin beta 12
PCDHGA10 protocadherin gamma subfamily A, 10
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PLTP phospholipid transfer protein
PML promyelocytic leukemia
PNPLA3 patatin-like phospholipase domain containing 3
POM121 POM121 transmembrane nucleoporin
PPP6R2 protein phosphatase 6, regulatory subunit 2
PRDX2 peroxiredoxin 2
PRSS53 protease, serine, 53
RAB11B RAB11B, member RAS oncogene family
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RBFA ribosome binding factor A (putative)
RBM5 RNA binding motif protein 5
REC8 REC8 meiotic recombination protein
RGS4 regulator of G-protein signaling 4
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RNFT1 ring finger protein, transmembrane 1
RPL13P5 ribosomal protein L13 pseudogene 5
RPL35A ribosomal protein L35a
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RRH retinal pigment epithelium-derived rhodopsin homolog
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SDC2 syndecan 2
SH3BP2 SH3-domain binding protein 2
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
SLCO4C1 solute carrier organic anion transporter family, member 4C1
SMAD1 SMAD family member 1
SNCG synuclein, gamma (breast cancer-specific protein 1)
SOCS7 suppressor of cytokine signaling 7
SOS2 son of sevenless homolog 2 (Drosophila)
SPATA5L1 spermatogenesis associated 5-like 1
SPTBN5 spectrin, beta, non-erythrocytic 5
SRSF7 serine/arginine-rich splicing factor 7
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
STK24 serine/threonine kinase 24
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
SWAP70 SWAP switching B-cell complex 70kDa subunit
TBC1D2 TBC1 domain family, member 2
TEX15 testis expressed 15
THRB thyroid hormone receptor, beta
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TSPAN9 tetraspanin 9
TTC9 tetratricopeptide repeat domain 9
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1
ZBTB7A zinc finger and BTB domain containing 7A
ZFX zinc finger protein, X-linked
ZNF236 zinc finger protein 236
ZNF280A zinc finger protein 280A
ZNF287 zinc finger protein 287
ZNF639 zinc finger protein 639

decreased expression

Symbol Name
ACY1 aminoacylase 1
AFAP1 actin filament associated protein 1
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AMT aminomethyltransferase
ANXA2P3 annexin A2 pseudogene 3
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ASB6 ankyrin repeat and SOCS box containing 6
ASUN asunder spermatogenesis regulator
B9D2 B9 protein domain 2
BMP4 bone morphogenetic protein 4
C1ORF105 chromosome 1 open reading frame 105
C2ORF54 chromosome 2 open reading frame 54
C5AR2 complement component 5a receptor 2
C7ORF43 chromosome 7 open reading frame 43
C8ORF44 chromosome 8 open reading frame 44
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CDC25A cell division cycle 25A
CENPO centromere protein O
CFD complement factor D (adipsin)
CHRM3 cholinergic receptor, muscarinic 3
CLDN9 claudin 9
CPPED1 calcineurin-like phosphoesterase domain containing 1
FBXL7 F-box and leucine-rich repeat protein 7
FGGY FGGY carbohydrate kinase domain containing
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GAMT guanidinoacetate N-methyltransferase
GMPR guanosine monophosphate reductase
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GPATCH2L G patch domain containing 2-like
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
H1F0 H1 histone family, member 0
HDAC11 histone deacetylase 11
IFT81 intraflagellar transport 81
ITGA10 integrin, alpha 10
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KIF20A kinesin family member 20A
KLK6 kallikrein-related peptidase 6
KRT13 keratin 13, type I
LHX6 LIM homeobox 6
LMNB1 lamin B1
MAST3 microtubule associated serine/threonine kinase 3
MBNL3 muscleblind-like splicing regulator 3
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MRPL17 mitochondrial ribosomal protein L17
NPM3 nucleophosmin/nucleoplasmin 3
NPY5R neuropeptide Y receptor Y5
NRTN neurturin
NT5E 5'-nucleotidase, ecto (CD73)
NUP62CL nucleoporin 62kDa C-terminal like
OASL 2'-5'-oligoadenylate synthetase-like
OR12D2 olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)
PARD6A par-6 family cell polarity regulator alpha
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PDIA3 protein disulfide isomerase family A, member 3
PEX26 peroxisomal biogenesis factor 26
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLA2G15 phospholipase A2, group XV
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PMCHL1 pro-melanin-concentrating hormone-like 1, pseudogene
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
PPAN peter pan homolog (Drosophila)
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
PYCR1 pyrroline-5-carboxylate reductase 1
RAB3A RAB3A, member RAS oncogene family
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RLN1 relaxin 1
RNF121 ring finger protein 121
RNF208 ring finger protein 208
ROM1 retinal outer segment membrane protein 1
RPL10L ribosomal protein L10-like
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SIDT1 SID1 transmembrane family, member 1
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
SNUPN snurportin 1
STARD3 StAR-related lipid transfer (START) domain containing 3
TH tyrosine hydroxylase
THAP7 THAP domain containing 7
TLN1 talin 1
TMEM53 transmembrane protein 53
TOP3B topoisomerase (DNA) III beta
TOR3A torsin family 3, member A
TRIM5 tripartite motif containing 5
TRIP10 thyroid hormone receptor interactor 10
TSPYL2 TSPY-like 2
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
USP27X ubiquitin specific peptidase 27, X-linked
VGF VGF nerve growth factor inducible
WDR19 WD repeat domain 19
WDR4 WD repeat domain 4
ZBED1 zinc finger, BED-type containing 1
ZBTB44 zinc finger and BTB domain containing 44
ZNF365 zinc finger protein 365
ZNF532 zinc finger protein 532
ZW10 zw10 kinetochore protein