amiprilose-3000 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

193 genes differentially expressed following the amiprilose-3000 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
AIPL1 aryl hydrocarbon receptor interacting protein-like 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
APOA1 apolipoprotein A-I
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38
ARTN artemin
ATP13A2 ATPase type 13A2
ATXN3L ataxin 3-like
AVPR1A arginine vasopressin receptor 1A
BEND5 BEN domain containing 5
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
CAV1 caveolin 1, caveolae protein, 22kDa
CCDC40 coiled-coil domain containing 40
CD300C CD300c molecule
CDA cytidine deaminase
CEACAM21 carcinoembryonic antigen-related cell adhesion molecule 21
CEP112 centrosomal protein 112kDa
CYHR1 cysteine/histidine-rich 1
DGCR8 DGCR8 microprocessor complex subunit
DNAI2 dynein, axonemal, intermediate chain 2
DOPEY2 dopey family member 2
DPEP2 dipeptidase 2
DSC3 desmocollin 3
EDDM3A epididymal protein 3A
EFNA4 ephrin-A4
EHMT1 euchromatic histone-lysine N-methyltransferase 1
EPHB1 EPH receptor B1
FABP6 fatty acid binding protein 6, ileal
FAM189A1 family with sequence similarity 189, member A1
FAM215A family with sequence similarity 215, member A (non-protein coding)
FBN1 fibrillin 1
FMO5 flavin containing monooxygenase 5
GLP1R glucagon-like peptide 1 receptor
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GPR20 G protein-coupled receptor 20
GRHL2 grainyhead-like 2 (Drosophila)
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
INPP5K inositol polyphosphate-5-phosphatase K
ITGB8 integrin, beta 8
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
KLC2 kinesin light chain 2
KLF5 Kruppel-like factor 5 (intestinal)
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LIMD2 LIM domain containing 2
LRP1 low density lipoprotein receptor-related protein 1
LY6G6C lymphocyte antigen 6 complex, locus G6C
MECOM MDS1 and EVI1 complex locus
MED14 mediator complex subunit 14
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
MYH11 myosin, heavy chain 11, smooth muscle
MYRF myelin regulatory factor
NBR2 neighbor of BRCA1 gene 2 (non-protein coding)
NCOR2 nuclear receptor corepressor 2
NF2 neurofibromin 2 (merlin)
NMT1 N-myristoyltransferase 1
NRG2 neuregulin 2
NSFL1C NSFL1 (p97) cofactor (p47)
NTN1 netrin 1
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
OPLAH 5-oxoprolinase (ATP-hydrolysing)
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PAIP2B poly(A) binding protein interacting protein 2B
PAX2 paired box 2
PCSK6 proprotein convertase subtilisin/kexin type 6
PEG10 paternally expressed 10
PLCE1 phospholipase C, epsilon 1
PNMAL1 paraneoplastic Ma antigen family-like 1
PODXL2 podocalyxin-like 2
PYCRL pyrroline-5-carboxylate reductase-like
RAB11B RAB11B, member RAS oncogene family
RCE1 Ras converting CAAX endopeptidase 1
REM1 RAS (RAD and GEM)-like GTP-binding 1
RIMS1 regulating synaptic membrane exocytosis 1
RNF122 ring finger protein 122
ROR1 receptor tyrosine kinase-like orphan receptor 1
RPL7 ribosomal protein L7
RS1 retinoschisin 1
SCIN scinderin
SELL selectin L
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
STS steroid sulfatase (microsomal), isozyme S
SUSD5 sushi domain containing 5
TBX5 T-box 5
TEAD3 TEA domain family member 3
TEX13A testis expressed 13A
THBD thrombomodulin
TMEM144 transmembrane protein 144
TMEM242 transmembrane protein 242
TNP2 transition protein 2 (during histone to protamine replacement)
TPM2 tropomyosin 2 (beta)
TUBA4B tubulin, alpha 4b
UNC93A unc-93 homolog A (C. elegans)
VCX2 variable charge, X-linked 2
VPS16 vacuolar protein sorting 16 homolog (S. cerevisiae)
WIPI2 WD repeat domain, phosphoinositide interacting 2

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ALDOAP2 aldolase A, fructose-bisphosphate pseudogene 2
ANXA2P3 annexin A2 pseudogene 3
ARG1 arginase 1
ASAP1-IT1 ASAP1 intronic transcript 1
BTBD18 BTB (POZ) domain containing 18
C1ORF159 chromosome 1 open reading frame 159
C3ORF14 chromosome 3 open reading frame 14
CCDC106 coiled-coil domain containing 106
CDHR2 cadherin-related family member 2
CLCN5 chloride channel, voltage-sensitive 5
COPG2IT1 COPG2 imprinted transcript 1 (non-protein coding)
CRELD1 cysteine-rich with EGF-like domains 1
CXCL2 chemokine (C-X-C motif) ligand 2
DCAF17 DDB1 and CUL4 associated factor 17
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
FAM13C family with sequence similarity 13, member C
FAM53B family with sequence similarity 53, member B
FBXL7 F-box and leucine-rich repeat protein 7
FHL3 four and a half LIM domains 3
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GID4 GID complex subunit 4
GIF gastric intrinsic factor (vitamin B synthesis)
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
GPR3 G protein-coupled receptor 3
GRPR gastrin-releasing peptide receptor
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa
HIST1H1T histone cluster 1, H1t
HIST1H3G histone cluster 1, H3g
HOXA2 homeobox A2
HOXB9 homeobox B9
HOXC10 homeobox C10
HPR haptoglobin-related protein
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFT140 intraflagellar transport 140
IFT54 intraflagellar transport 54
JPH3 junctophilin 3
KDM5C lysine (K)-specific demethylase 5C
KIAA0319L KIAA0319-like
KIAA1107 KIAA1107
KIAA1456 KIAA1456
LRRC20 leucine rich repeat containing 20
MAP6D1 MAP6 domain containing 1
MMP9 matrix metallopeptidase 9
MRAS muscle RAS oncogene homolog
MTSS1L metastasis suppressor 1-like
NCS1 neuronal calcium sensor 1
NSUN6 NOP2/Sun domain family, member 6
NUDT2 nudix (nucleoside diphosphate linked moiety X)-type motif 2
OCA2 oculocutaneous albinism II
OCLN occludin
PBOV1 prostate and breast cancer overexpressed 1
PCBP4 poly(rC) binding protein 4
PCDH12 protocadherin 12
PDE7B phosphodiesterase 7B
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PEX13 peroxisomal biogenesis factor 13
PLA2G3 phospholipase A2, group III
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6
PPP1R2P9 protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 9
PRSS53 protease, serine, 53
PYGB phosphorylase, glycogen; brain
RAB17 RAB17, member RAS oncogene family
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RAP1GAP2 RAP1 GTPase activating protein 2
RBM12B-AS1 RBM12B antisense RNA 1
SCN5A sodium channel, voltage gated, type V alpha subunit
SCRT1 scratch family zinc finger 1
SFRP5 secreted frizzled-related protein 5
SH3GLB2 SH3-domain GRB2-like endophilin B2
SIGLEC15 sialic acid binding Ig-like lectin 15
SKA1 spindle and kinetochore associated complex subunit 1
SLC10A3 solute carrier family 10, member 3
SLC16A4 solute carrier family 16, member 4
SLC16A6 solute carrier family 16, member 6
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SMR3B submaxillary gland androgen regulated protein 3B
SPATA1 spermatogenesis associated 1
TCHH trichohyalin
TIMP2 TIMP metallopeptidase inhibitor 2
TMEM180 transmembrane protein 180
TMEM209 transmembrane protein 209
TPSB2 tryptase beta 2 (gene/pseudogene)
TRIM36 tripartite motif containing 36
VEGFB vascular endothelial growth factor B
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
VPREB1 pre-B lymphocyte 1
ZFHX3 zinc finger homeobox 3
ZNF428 zinc finger protein 428
ZNF747 zinc finger protein 747
ZNF749 zinc finger protein 749