amoxapine-1513 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the amoxapine-1513 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADCY7 adenylate cyclase 7
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
ADRA1D adrenoceptor alpha 1D
APOM apolipoprotein M
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
ARHGAP33 Rho GTPase activating protein 33
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ASPN asporin
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BHLHE41 basic helix-loop-helix family, member e41
C4ORF29 chromosome 4 open reading frame 29
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CACYBP calcyclin binding protein
CD160 CD160 molecule
CDK18 cyclin-dependent kinase 18
CES3 carboxylesterase 3
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CLDN11 claudin 11
CNN3 calponin 3, acidic
CNTNAP1 contactin associated protein 1
CPA4 carboxypeptidase A4
CRHR2 corticotropin releasing hormone receptor 2
CXCL6 chemokine (C-X-C motif) ligand 6
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
DDIT4 DNA-damage-inducible transcript 4
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2
EFR3B EFR3 homolog B (S. cerevisiae)
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EPN2 epsin 2
FAM186A family with sequence similarity 186, member A
FAM46C family with sequence similarity 46, member C
FAS Fas cell surface death receptor
FER1L4 fer-1-like family member 4, pseudogene (functional)
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
GOLGA2 golgin A2
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GRIK5 glutamate receptor, ionotropic, kainate 5
HDAC7 histone deacetylase 7
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXA11 homeobox A11
HPS1 Hermansky-Pudlak syndrome 1
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IL6ST interleukin 6 signal transducer
IPW imprinted in Prader-Willi syndrome (non-protein coding)
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
KLHL24 kelch-like family member 24
LHX6 LIM homeobox 6
LRRC37A3 leucine rich repeat containing 37, member A3
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEGF6 multiple EGF-like-domains 6
MPO myeloperoxidase
NELL2 NEL-like 2 (chicken)
NOTCH4 notch 4
NOVA1 neuro-oncological ventral antigen 1
NOX1 NADPH oxidase 1
NR6A1 nuclear receptor subfamily 6, group A, member 1
OASL 2'-5'-oligoadenylate synthetase-like
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PMEL premelanosome protein
PRAMEF11 PRAME family member 11
PRPH peripherin
PTHLH parathyroid hormone-like hormone
RAB3A RAB3A, member RAS oncogene family
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RBM5 RNA binding motif protein 5
REEP2 receptor accessory protein 2
RIF1 replication timing regulatory factor 1
RPL10L ribosomal protein L10-like
SCG2 secretogranin II
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SIGLEC7 sialic acid binding Ig-like lectin 7
SLC12A8 solute carrier family 12, member 8
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SPG20 spastic paraplegia 20 (Troyer syndrome)
SSTR5 somatostatin receptor 5
SWAP70 SWAP switching B-cell complex 70kDa subunit
SYN2 synapsin II
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
TBC1D30 TBC1 domain family, member 30
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
THAP9 THAP domain containing 9
THRB thyroid hormone receptor, beta
TMEM209 transmembrane protein 209
TNK2 tyrosine kinase, non-receptor, 2
TRIL TLR4 interactor with leucine-rich repeats
TRIM10 tripartite motif containing 10
TRPM3 transient receptor potential cation channel, subfamily M, member 3
UBA7 ubiquitin-like modifier activating enzyme 7
WIPF1 WAS/WASL interacting protein family, member 1
ZNF500 zinc finger protein 500

decreased expression

Symbol Name
ACADSB acyl-CoA dehydrogenase, short/branched chain
ACTG2 actin, gamma 2, smooth muscle, enteric
ADAM15 ADAM metallopeptidase domain 15
AEN apoptosis enhancing nuclease
APOLD1 apolipoprotein L domain containing 1
ARC activity-regulated cytoskeleton-associated protein
ASB9 ankyrin repeat and SOCS box containing 9
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BMP4 bone morphogenetic protein 4
BTBD2 BTB (POZ) domain containing 2
C11ORF80 chromosome 11 open reading frame 80
C17ORF70 chromosome 17 open reading frame 70
C1ORF105 chromosome 1 open reading frame 105
C6ORF47 chromosome 6 open reading frame 47
C9ORF40 chromosome 9 open reading frame 40
CAPN15 calpain 15
CDK3 cyclin-dependent kinase 3
CEP70 centrosomal protein 70kDa
CHKB choline kinase beta
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CORO7 coronin 7
CST6 cystatin E/M
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
DNAL4 dynein, axonemal, light chain 4
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DUSP13 dual specificity phosphatase 13
DUSP5 dual specificity phosphatase 5
EFHD1 EF-hand domain family, member D1
ERF Ets2 repressor factor
FAM189A2 family with sequence similarity 189, member A2
FBRS fibrosin
FGD1 FYVE, RhoGEF and PH domain containing 1
FHOD1 formin homology 2 domain containing 1
FSD1 fibronectin type III and SPRY domain containing 1
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GMPR guanosine monophosphate reductase
GPR19 G protein-coupled receptor 19
GRPR gastrin-releasing peptide receptor
HDAC5 histone deacetylase 5
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HIST1H2AJ histone cluster 1, H2aj
IL4R interleukin 4 receptor
INPP5J inositol polyphosphate-5-phosphatase J
IRF2BP1 interferon regulatory factor 2 binding protein 1
KIAA0125 KIAA0125
KIF16B kinesin family member 16B
KRT13 keratin 13, type I
MAP9 microtubule-associated protein 9
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MCOLN1 mucolipin 1
MEFV Mediterranean fever
METTL8 methyltransferase like 8
MITF microphthalmia-associated transcription factor
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
MTG1 mitochondrial ribosome-associated GTPase 1
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MYO1E myosin IE
NT5DC3 5'-nucleotidase domain containing 3
PCDHB3 protocadherin beta 3
PIDD1 p53-induced death domain protein 1
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLEKHO2 pleckstrin homology domain containing, family O member 2
PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F
PROCR protein C receptor, endothelial
RAB30 RAB30, member RAS oncogene family
RAD54L2 RAD54-like 2 (S. cerevisiae)
ROM1 retinal outer segment membrane protein 1
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
S100A4 S100 calcium binding protein A4
SETD1A SET domain containing 1A
SFT2D2 SFT2 domain containing 2
SKA1 spindle and kinetochore associated complex subunit 1
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLMO1 slowmo homolog 1 (Drosophila)
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SNHG20 small nucleolar RNA host gene 20
STRA6 stimulated by retinoic acid 6
SULT4A1 sulfotransferase family 4A, member 1
TESC tescalcin
TESK2 testis-specific kinase 2
TEX40 testis expressed 40
TFF2 trefoil factor 2
THAP7 THAP domain containing 7
TMC5 transmembrane channel-like 5
TMCC2 transmembrane and coiled-coil domain family 2
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TRIM5 tripartite motif containing 5
UNC93B1 unc-93 homolog B1 (C. elegans)
UPP1 uridine phosphorylase 1
USP36 ubiquitin specific peptidase 36
VEGFB vascular endothelial growth factor B
XAB2 XPA binding protein 2
ZDHHC18 zinc finger, DHHC-type containing 18
ZNF747 zinc finger protein 747
ZNF76 zinc finger protein 76
ZSCAN31 zinc finger and SCAN domain containing 31