amoxapine-6650 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the amoxapine-6650 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2
ACACB acetyl-CoA carboxylase beta
ADGRL2 adhesion G protein-coupled receptor L2
ALDOAP2 aldolase A, fructose-bisphosphate pseudogene 2
ANGEL2 angel homolog 2 (Drosophila)
ANK2 ankyrin 2, neuronal
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
ARHGAP28 Rho GTPase activating protein 28
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ARNT aryl hydrocarbon receptor nuclear translocator
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
BEGAIN brain-enriched guanylate kinase-associated
BMP2 bone morphogenetic protein 2
BMP8A bone morphogenetic protein 8a
BMPR1B bone morphogenetic protein receptor, type IB
CEP152 centrosomal protein 152kDa
CIB2 calcium and integrin binding family member 2
CLCN6 chloride channel, voltage-sensitive 6
COBL cordon-bleu WH2 repeat protein
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
DBF4B DBF4 zinc finger B
DENND3 DENN/MADD domain containing 3
DLC1 DLC1 Rho GTPase activating protein
DPF1 D4, zinc and double PHD fingers family 1
DSCAM Down syndrome cell adhesion molecule
EBF2 early B-cell factor 2
EDRF1 erythroid differentiation regulatory factor 1
EFR3B EFR3 homolog B (S. cerevisiae)
EHD2 EH-domain containing 2
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1)
EPS8L1 EPS8-like 1
ERO1LB ERO1-like beta (S. cerevisiae)
ETV6 ets variant 6
FGB fibrinogen beta chain
FRMD1 FERM domain containing 1
GREM1 gremlin 1, DAN family BMP antagonist
GRM7 glutamate receptor, metabotropic 7
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFNA17 interferon, alpha 17
INSIG1 insulin induced gene 1
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3
KIF21B kinesin family member 21B
KL klotho
KRTAP5-8 keratin associated protein 5-8
LAT2 linker for activation of T cells family, member 2
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
LIMD2 LIM domain containing 2
LINC00115 long intergenic non-protein coding RNA 115
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
LRP4 low density lipoprotein receptor-related protein 4
LRRK1 leucine-rich repeat kinase 1
MAPK10 mitogen-activated protein kinase 10
MTCP1 mature T-cell proliferation 1
MUC3B mucin 3B, cell surface associated
MYH2 myosin, heavy chain 2, skeletal muscle, adult
MYOZ3 myozenin 3
NEU3 sialidase 3 (membrane sialidase)
NOX1 NADPH oxidase 1
NR1I2 nuclear receptor subfamily 1, group I, member 2
NRAP nebulin-related anchoring protein
NRCAM neuronal cell adhesion molecule
NXPE4 neurexophilin and PC-esterase domain family, member 4
ODAM odontogenic, ameloblast asssociated
PBOV1 prostate and breast cancer overexpressed 1
PCDHB17P protocadherin beta 17 pseudogene
PCDHB3 protocadherin beta 3
PDZK1 PDZ domain containing 1
PHC3 polyhomeotic homolog 3 (Drosophila)
PPP4R4 protein phosphatase 4, regulatory subunit 4
PTAFR platelet-activating factor receptor
PTPRR protein tyrosine phosphatase, receptor type, R
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic)
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
SCAND2P SCAN domain containing 2 pseudogene
SCN5A sodium channel, voltage gated, type V alpha subunit
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein
SH2D3A SH2 domain containing 3A
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SLA Src-like-adaptor
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SPHK2 sphingosine kinase 2
STMN4 stathmin-like 4
SYT13 synaptotagmin XIII
TACR1 tachykinin receptor 1
TADA3 transcriptional adaptor 3
TBKBP1 TBK1 binding protein 1
TBX5 T-box 5
TOX thymocyte selection-associated high mobility group box
TRIM15 tripartite motif containing 15
TSC2 tuberous sclerosis 2
ZNF407 zinc finger protein 407
ZNF484 zinc finger protein 484
ZNF783 zinc finger family member 783
ZSCAN2 zinc finger and SCAN domain containing 2

decreased expression

Symbol Name
ACSL5 acyl-CoA synthetase long-chain family member 5
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ARSB arylsulfatase B
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATAD3A ATPase family, AAA domain containing 3A
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BFSP1 beaded filament structural protein 1, filensin
C11ORF30 chromosome 11 open reading frame 30
C9ORF40 chromosome 9 open reading frame 40
CA5BP1 carbonic anhydrase VB pseudogene 1
CCDC106 coiled-coil domain containing 106
CCDC132 coiled-coil domain containing 132
CCNJL cyclin J-like
CENPT centromere protein T
CNGB3 cyclic nucleotide gated channel beta 3
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CXCL3 chemokine (C-X-C motif) ligand 3
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
ECE1 endothelin converting enzyme 1
ELP6 elongator acetyltransferase complex subunit 6
ERN2 endoplasmic reticulum to nucleus signaling 2
FLT4 fms-related tyrosine kinase 4
GMPR guanosine monophosphate reductase
GPRIN2 G protein regulated inducer of neurite outgrowth 2
HDAC11 histone deacetylase 11
HIST1H1D histone cluster 1, H1d
HIST1H3A histone cluster 1, H3a
HIST1H4E histone cluster 1, H4e
HLA-DMB major histocompatibility complex, class II, DM beta
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HOMER2 homer scaffolding protein 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFT140 intraflagellar transport 140
KLC2 kinesin light chain 2
LAX1 lymphocyte transmembrane adaptor 1
LMCD1 LIM and cysteine-rich domains 1
LPAR4 lysophosphatidic acid receptor 4
MB myoglobin
MEGF8 multiple EGF-like-domains 8
MMP3 matrix metallopeptidase 3
MOCS1 molybdenum cofactor synthesis 1
MOCS3 molybdenum cofactor synthesis 3
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MSRA methionine sulfoxide reductase A
MTA2 metastasis associated 1 family, member 2
MTSS1L metastasis suppressor 1-like
NIPSNAP3B nipsnap homolog 3B (C. elegans)
NME5 NME/NM23 family member 5
NUP62CL nucleoporin 62kDa C-terminal like
NUS1P3 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) pseudogene 3
ODF2 outer dense fiber of sperm tails 2
OVGP1 oviductal glycoprotein 1, 120kDa
PCOLCE procollagen C-endopeptidase enhancer
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PGPEP1 pyroglutamyl-peptidase I
PICK1 protein interacting with PRKCA 1
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLD2 phospholipase D2
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLEKHO2 pleckstrin homology domain containing, family O member 2
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PRSS22 protease, serine, 22
PRSS53 protease, serine, 53
RAB40A RAB40A, member RAS oncogene family
RHOBTB2 Rho-related BTB domain containing 2
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae)
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SP140L SP140 nuclear body protein-like
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAGLN transgelin
THBS3 thrombospondin 3
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TRAF2 TNF receptor-associated factor 2
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TTLL7 tubulin tyrosine ligase-like family member 7
TXK TXK tyrosine kinase
UNC119 unc-119 homolog (C. elegans)
USP27X ubiquitin specific peptidase 27, X-linked
VGF VGF nerve growth factor inducible
YOD1 YOD1 deubiquitinase
YY2 YY2 transcription factor
ZC3H3 zinc finger CCCH-type containing 3
ZMAT5 zinc finger, matrin-type 5
ZNF276 zinc finger protein 276
ZNF668 zinc finger protein 668
ZNF768 zinc finger protein 768