ampyrone-2086 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the ampyrone-2086 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
AGGF1 angiogenic factor with G patch and FHA domains 1
AKAP7 A kinase (PRKA) anchor protein 7
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ALPK1 alpha-kinase 1
APLP2 amyloid beta (A4) precursor-like protein 2
ARMC8 armadillo repeat containing 8
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
BAHCC1 BAH domain and coiled-coil containing 1
BCORL1 BCL6 corepressor-like 1
C10ORF10 chromosome 10 open reading frame 10
C1ORF105 chromosome 1 open reading frame 105
CCL20 chemokine (C-C motif) ligand 20
CD40 CD40 molecule, TNF receptor superfamily member 5
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CLSPN claspin
CLTCL1 clathrin, heavy chain-like 1
CPNE7 copine VII
CPT2 carnitine palmitoyltransferase 2
DBT dihydrolipoamide branched chain transacylase E2
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34
DSC2 desmocollin 2
EN2 engrailed homeobox 2
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM120C family with sequence similarity 120C
FBXO21 F-box protein 21
FCMR Fc fragment of IgM receptor
FLJ22184
FOXO1 forkhead box O1
FZD1 frizzled class receptor 1
GPR137 G protein-coupled receptor 137
HCFC1 host cell factor C1
HOMER3 homer scaffolding protein 3
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IGFBP5 insulin-like growth factor binding protein 5
IL27RA interleukin 27 receptor, alpha
ITGB5 integrin, beta 5
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8
KCNMB4 potassium channel subfamily M regulatory beta subunit 4
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KRT17 keratin 17, type I
LPP LIM domain containing preferred translocation partner in lipoma
LRRC40 leucine rich repeat containing 40
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta)
MDFIC MyoD family inhibitor domain containing
MED28 mediator complex subunit 28
MKL1 megakaryoblastic leukemia (translocation) 1
MUC1 mucin 1, cell surface associated
MXD3 MAX dimerization protein 3
MYO1D myosin ID
MYRF myelin regulatory factor
NAAA N-acylethanolamine acid amidase
NCAPH2 non-SMC condensin II complex, subunit H2
NMT2 N-myristoyltransferase 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
PDCD6 programmed cell death 6
PEX1 peroxisomal biogenesis factor 1
PGPEP1 pyroglutamyl-peptidase I
PHC1 polyhomeotic homolog 1 (Drosophila)
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PSD3 pleckstrin and Sec7 domain containing 3
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RIBC2 RIB43A domain with coiled-coils 2
RPL13P5 ribosomal protein L13 pseudogene 5
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RRAD Ras-related associated with diabetes
SETD6 SET domain containing 6
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SMC1A structural maintenance of chromosomes 1A
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SQSTM1 sequestosome 1
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TAOK1 TAO kinase 1
TBC1D5 TBC1 domain family, member 5
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TGOLN2 trans-golgi network protein 2
THBS3 thrombospondin 3
TIAM1 T-cell lymphoma invasion and metastasis 1
TIMELESS timeless circadian clock
TLN2 talin 2
TMEM40 transmembrane protein 40
TMEM53 transmembrane protein 53
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TTC39A tetratricopeptide repeat domain 39A
ZFHX3 zinc finger homeobox 3
ZMYM2 zinc finger, MYM-type 2
ZNF235 zinc finger protein 235
ZNF669 zinc finger protein 669
ZNF862 zinc finger protein 862

decreased expression

Symbol Name
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
ANXA2P3 annexin A2 pseudogene 3
ARF5 ADP-ribosylation factor 5
ARHGAP10 Rho GTPase activating protein 10
ARRB2 arrestin, beta 2
ATF7IP2 activating transcription factor 7 interacting protein 2
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BMP15 bone morphogenetic protein 15
BOLA1 bolA family member 1
BRIP1 BRCA1 interacting protein C-terminal helicase 1
C1ORF56 chromosome 1 open reading frame 56
C7ORF69 chromosome 7 open reading frame 69
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CCDC25 coiled-coil domain containing 25
CD70 CD70 molecule
CDK3 cyclin-dependent kinase 3
CNGB3 cyclic nucleotide gated channel beta 3
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DPH2 DPH2 homolog (S. cerevisiae)
ERCC5 excision repair cross-complementation group 5
EXOC5 exocyst complex component 5
FBXL7 F-box and leucine-rich repeat protein 7
FBXW12 F-box and WD repeat domain containing 12
FICD FIC domain containing
FMO4 flavin containing monooxygenase 4
FOXC1 forkhead box C1
GAREM GRB2 associated, regulator of MAPK1
GDAP1 ganglioside induced differentiation associated protein 1
GLT8D2 glycosyltransferase 8 domain containing 2
GPR176 G protein-coupled receptor 176
GRAMD1C GRAM domain containing 1C
GTPBP2 GTP binding protein 2
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HIST1H2BJ histone cluster 1, H2bj
HIST1H3G histone cluster 1, H3g
HOMER2 homer scaffolding protein 2
HPS6 Hermansky-Pudlak syndrome 6
HSPB8 heat shock 22kDa protein 8
IGBP1 immunoglobulin (CD79A) binding protein 1
IGFLR1 IGF-like family receptor 1
ITPKC inositol-trisphosphate 3-kinase C
KCTD15 potassium channel tetramerization domain containing 15
LPAR6 lysophosphatidic acid receptor 6
LY6G5C lymphocyte antigen 6 complex, locus G5C
MAGEA3 melanoma antigen family A3
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MKS1 Meckel syndrome, type 1
MOXD1 monooxygenase, DBH-like 1
MYLK myosin light chain kinase
NDE1 nudE neurodevelopment protein 1
NDRG4 NDRG family member 4
NR1H3 nuclear receptor subfamily 1, group H, member 3
NT5C 5', 3'-nucleotidase, cytosolic
NUDT13 nudix (nucleoside diphosphate linked moiety X)-type motif 13
P3H2 prolyl 3-hydroxylase 2
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PDGFRL platelet-derived growth factor receptor-like
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLSCR4 phospholipid scramblase 4
POLM polymerase (DNA directed), mu
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PSAT1 phosphoserine aminotransferase 1
PTPRR protein tyrosine phosphatase, receptor type, R
RAB20 RAB20, member RAS oncogene family
RAI2 retinoic acid induced 2
RHOC ras homolog family member C
SCARA3 scavenger receptor class A, member 3
SCYL2 SCY1-like 2 (S. cerevisiae)
SDC3 syndecan 3
SGPP1 sphingosine-1-phosphate phosphatase 1
SH3BGR SH3 domain binding glutamate-rich protein
SIRT3 sirtuin 3
SLC26A6 solute carrier family 26 (anion exchanger), member 6
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1
SLC46A3 solute carrier family 46, member 3
SMA4 glucuronidase, beta pseudogene
SPEG SPEG complex locus
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STK16 serine/threonine kinase 16
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
SYNE2 spectrin repeat containing, nuclear envelope 2
SYTL2 synaptotagmin-like 2
TESK2 testis-specific kinase 2
TGS1 trimethylguanosine synthase 1
TMEM120B transmembrane protein 120B
UEVLD UEV and lactate/malate dehyrogenase domains
USP19 ubiquitin specific peptidase 19
WDR41 WD repeat domain 41
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF134 zinc finger protein 134
ZNF254 zinc finger protein 254
ZNF276 zinc finger protein 276