ampyrone-2249 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the ampyrone-2249 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12
ADTRP androgen-dependent TFPI-regulating protein
AHNAK AHNAK nucleoprotein
AKAP4 A kinase (PRKA) anchor protein 4
AKAP8L A kinase (PRKA) anchor protein 8-like
ANKH ANKH inorganic pyrophosphate transport regulator
BAIAP3 BAI1-associated protein 3
C18ORF25 chromosome 18 open reading frame 25
CD1E CD1e molecule
CD4 CD4 molecule
CFAP70 cilia and flagella associated protein 70
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2
EFS embryonal Fyn-associated substrate
ELAC2 elaC ribonuclease Z 2
ELOVL5 ELOVL fatty acid elongase 5
ERN1 endoplasmic reticulum to nucleus signaling 1
EVI5 ecotropic viral integration site 5
FAM46C family with sequence similarity 46, member C
FCAR Fc fragment of IgA receptor
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3
GIPR gastric inhibitory polypeptide receptor
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
GPR137 G protein-coupled receptor 137
HBEGF heparin-binding EGF-like growth factor
HIST1H1D histone cluster 1, H1d
HIST1H3I histone cluster 1, H3i
HOMER3 homer scaffolding protein 3
HOXC5 homeobox C5
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
HYAL1 hyaluronoglucosaminidase 1
IGLJ3 immunoglobulin lambda joining 3
IL1RAP interleukin 1 receptor accessory protein
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JRK Jrk homolog (mouse)
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KCNMB2 potassium channel subfamily M regulatory beta subunit 2
LRP12 low density lipoprotein receptor-related protein 12
LTBP2 latent transforming growth factor beta binding protein 2
MAN1A2 mannosidase, alpha, class 1A, member 2
MAP4 microtubule-associated protein 4
MARK4 MAP/microtubule affinity-regulating kinase 4
MCTP1 multiple C2 domains, transmembrane 1
MTCP1 mature T-cell proliferation 1
N4BP3 NEDD4 binding protein 3
NCF4 neutrophil cytosolic factor 4, 40kDa
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NPR1 natriuretic peptide receptor 1
OMG oligodendrocyte myelin glycoprotein
ONECUT2 one cut homeobox 2
OSGIN2 oxidative stress induced growth inhibitor family member 2
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PARD6B par-6 family cell polarity regulator beta
PHC3 polyhomeotic homolog 3 (Drosophila)
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRDX2 peroxiredoxin 2
PRLR prolactin receptor
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
RAP1GAP RAP1 GTPase activating protein
RBM5 RNA binding motif protein 5
RHOH ras homolog family member H
RIN1 Ras and Rab interactor 1
RND1 Rho family GTPase 1
RNF122 ring finger protein 122
RPS4Y1 ribosomal protein S4, Y-linked 1
SGCE sarcoglycan, epsilon
SH3BP2 SH3-domain binding protein 2
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SLMO1 slowmo homolog 1 (Drosophila)
SNX13 sorting nexin 13
SOAT2 sterol O-acyltransferase 2
SOS2 son of sevenless homolog 2 (Drosophila)
SPTBN1 spectrin, beta, non-erythrocytic 1
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
SYNDIG1 synapse differentiation inducing 1
TAAR5 trace amine associated receptor 5
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM209 transmembrane protein 209
TMEM212 transmembrane protein 212
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
USB1 U6 snRNA biogenesis 1
WIPI2 WD repeat domain, phosphoinositide interacting 2
WNT2B wingless-type MMTV integration site family, member 2B
YPEL1 yippee-like 1 (Drosophila)
ZNF639 zinc finger protein 639

decreased expression

Symbol Name
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ADCY6 adenylate cyclase 6
AGMAT agmatine ureohydrolase (agmatinase)
ALPK1 alpha-kinase 1
ANKRD7 ankyrin repeat domain 7
APLP1 amyloid beta (A4) precursor-like protein 1
ARC activity-regulated cytoskeleton-associated protein
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ARMC4 armadillo repeat containing 4
ASPN asporin
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BAHCC1 BAH domain and coiled-coil containing 1
BMP15 bone morphogenetic protein 15
BTBD2 BTB (POZ) domain containing 2
C14ORF79 chromosome 14 open reading frame 79
CA5BP1 carbonic anhydrase VB pseudogene 1
CALCOCO1 calcium binding and coiled-coil domain 1
CCDC69 coiled-coil domain containing 69
CCDC85C coiled-coil domain containing 85C
CD3D CD3d molecule, delta (CD3-TCR complex)
CD79B CD79b molecule, immunoglobulin-associated beta
CENPO centromere protein O
CERS4 ceramide synthase 4
CES3 carboxylesterase 3
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CIC capicua transcriptional repressor
CLDN1 claudin 1
CLSPN claspin
CORT cortistatin
CRLF1 cytokine receptor-like factor 1
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DOK5 docking protein 5
DTX2 deltex 2, E3 ubiquitin ligase
ETNK2 ethanolamine kinase 2
FAM155A family with sequence similarity 155, member A
FAM169A family with sequence similarity 169, member A
FAM204A family with sequence similarity 204, member A
FBXL8 F-box and leucine-rich repeat protein 8
FGL1 fibrinogen-like 1
GCC1 GRIP and coiled-coil domain containing 1
GLRA1 glycine receptor, alpha 1
GPR157 G protein-coupled receptor 157
GPR87 G protein-coupled receptor 87
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HIST1H3E histone cluster 1, H3e
HOXC8 homeobox C8
IDI2-AS1 IDI2 antisense RNA 1
IFT54 intraflagellar transport 54
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KIF13A kinesin family member 13A
KREMEN2 kringle containing transmembrane protein 2
LAMP3 lysosomal-associated membrane protein 3
LARP6 La ribonucleoprotein domain family, member 6
LHX6 LIM homeobox 6
LIME1 Lck interacting transmembrane adaptor 1
LOC729164 hCG1732469
LONP2 lon peptidase 2, peroxisomal
LRP2 low density lipoprotein receptor-related protein 2
MED9 mediator complex subunit 9
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MYOZ1 myozenin 1
NDE1 nudE neurodevelopment protein 1
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
OVOL1 ovo-like zinc finger 1
PARG poly (ADP-ribose) glycohydrolase
PC pyruvate carboxylase
POM121 POM121 transmembrane nucleoporin
R3HCC1L R3H domain and coiled-coil containing 1-like
RAB3A RAB3A, member RAS oncogene family
RAB40C RAB40C, member RAS oncogene family
RAD54L2 RAD54-like 2 (S. cerevisiae)
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RFPL3 ret finger protein-like 3
RHOBTB2 Rho-related BTB domain containing 2
RNF39 ring finger protein 39
RWDD3 RWD domain containing 3
SAYSD1 SAYSVFN motif domain containing 1
SDC3 syndecan 3
SEC14L5 SEC14-like 5 (S. cerevisiae)
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLIT2 slit homolog 2 (Drosophila)
SRD5A3 steroid 5 alpha-reductase 3
STX1A syntaxin 1A (brain)
SYNC syncoilin, intermediate filament protein
TIGD6 tigger transposable element derived 6
TLR2 toll-like receptor 2
TNRC6B trinucleotide repeat containing 6B
TRDMT1 tRNA aspartic acid methyltransferase 1
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TUBA3C tubulin, alpha 3c
UBTD1 ubiquitin domain containing 1
WDR62 WD repeat domain 62
WDR76 WD repeat domain 76
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZBED1 zinc finger, BED-type containing 1
ZNF701 zinc finger protein 701