ampyrone-6845 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the ampyrone-6845 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAK1 AP2 associated kinase 1
ADGRG1 adhesion G protein-coupled receptor G1
AEBP1 AE binding protein 1
ALAD aminolevulinate dehydratase
AP3B2 adaptor-related protein complex 3, beta 2 subunit
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3
APOE apolipoprotein E
ARTN artemin
BMP10 bone morphogenetic protein 10
CA5B carbonic anhydrase VB, mitochondrial
CHN2 chimerin 2
CHRM3 cholinergic receptor, muscarinic 3
CTNS cystinosin, lysosomal cystine transporter
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
DLC1 DLC1 Rho GTPase activating protein
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2
EAF2 ELL associated factor 2
EFNB3 ephrin-B3
EHBP1L1 EH domain binding protein 1-like 1
ELL2 elongation factor, RNA polymerase II, 2
EMCN endomucin
EPX eosinophil peroxidase
ERCC2 excision repair cross-complementation group 2
EYA3 EYA transcriptional coactivator and phosphatase 3
FAM214B family with sequence similarity 214, member B
FBLN1 fibulin 1
FLOT1 flotillin 1
GABRD gamma-aminobutyric acid (GABA) A receptor, delta
GABRQ gamma-aminobutyric acid (GABA) A receptor, theta
GALR2 galanin receptor 2
GPR176 G protein-coupled receptor 176
HOXB3 homeobox B3
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
ICA1 islet cell autoantigen 1, 69kDa
ICAM1 intercellular adhesion molecule 1
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IL36G interleukin 36, gamma
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2
KLHL18 kelch-like family member 18
KRT31 keratin 31, type I
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LIN7A lin-7 homolog A (C. elegans)
LINC00472 long intergenic non-protein coding RNA 472
MAP2 microtubule-associated protein 2
MAP2K7 mitogen-activated protein kinase kinase 7
MKL1 megakaryoblastic leukemia (translocation) 1
MYH14 myosin, heavy chain 14, non-muscle
MYL4 myosin, light chain 4, alkali; atrial, embryonic
MYLK myosin light chain kinase
MYT1 myelin transcription factor 1
NBL1 neuroblastoma 1, DAN family BMP antagonist
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NPR3 natriuretic peptide receptor 3
NRL neural retina leucine zipper
OR1D2 olfactory receptor, family 1, subfamily D, member 2
PAOX polyamine oxidase (exo-N4-amino)
PAPPA2 pappalysin 2
PCDH12 protocadherin 12
PMEL premelanosome protein
PXDC1 PX domain containing 1
RAD52 RAD52 homolog (S. cerevisiae)
RBP4 retinol binding protein 4, plasma
RIMS3 regulating synaptic membrane exocytosis 3
RNF122 ring finger protein 122
RS1 retinoschisin 1
RYR1 ryanodine receptor 1 (skeletal)
S100A7 S100 calcium binding protein A7
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SIGLEC6 sialic acid binding Ig-like lectin 6
SLC17A2 solute carrier family 17, member 2
SLC26A4 solute carrier family 26 (anion exchanger), member 4
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SULT4A1 sulfotransferase family 4A, member 1
SWAP70 SWAP switching B-cell complex 70kDa subunit
TAOK2 TAO kinase 2
TBC1D2 TBC1 domain family, member 2
TBX5 T-box 5
TEF thyrotrophic embryonic factor
TPMT thiopurine S-methyltransferase
TRD T cell receptor delta locus
TSC22D2 TSC22 domain family, member 2
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WDTC1 WD and tetratricopeptide repeats 1
WNT2 wingless-type MMTV integration site family member 2
WSCD1 WSC domain containing 1
XYLT1 xylosyltransferase I
YY2 YY2 transcription factor
ZBTB44 zinc finger and BTB domain containing 44
ZCCHC24 zinc finger, CCHC domain containing 24
ZNF224 zinc finger protein 224
ZNF235 zinc finger protein 235
ZNF236 zinc finger protein 236
ZNF532 zinc finger protein 532
ZNF747 zinc finger protein 747

decreased expression

Symbol Name
A1CF APOBEC1 complementation factor
A2M alpha-2-macroglobulin
A4GALT alpha 1,4-galactosyltransferase
ACTL8 actin-like 8
ADAP2 ArfGAP with dual PH domains 2
ADGRG2 adhesion G protein-coupled receptor G2
ALS2CL ALS2 C-terminal like
ASIC3 acid sensing (proton gated) ion channel 3
ASPHD1 aspartate beta-hydroxylase domain containing 1
BAK1 BCL2-antagonist/killer 1
BGLAP bone gamma-carboxyglutamate (gla) protein
C1ORF159 chromosome 1 open reading frame 159
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CAMK1D calcium/calmodulin-dependent protein kinase ID
CBX8 chromobox homolog 8
CCNO cyclin O
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CIDEB cell death-inducing DFFA-like effector b
CLCF1 cardiotrophin-like cytokine factor 1
CNKSR1 connector enhancer of kinase suppressor of Ras 1
CNKSR2 connector enhancer of kinase suppressor of Ras 2
CTAGE9 CTAGE family, member 9
CTH cystathionine gamma-lyase
CXORF56 chromosome X open reading frame 56
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DEAF1 DEAF1 transcription factor
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal
DMTN dematin actin binding protein
DUSP13 dual specificity phosphatase 13
EGFL7 EGF-like-domain, multiple 7
ERMAP erythroblast membrane-associated protein (Scianna blood group)
FAM155B family with sequence similarity 155, member B
FAM46C family with sequence similarity 46, member C
FBXL2 F-box and leucine-rich repeat protein 2
FRK fyn-related Src family tyrosine kinase
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPR87 G protein-coupled receptor 87
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GSTTP1 glutathione S-transferase theta pseudogene 1
HDAC11 histone deacetylase 11
HIST2H2AA3 histone cluster 2, H2aa3
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
ICK intestinal cell (MAK-like) kinase
IFI35 interferon-induced protein 35
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
KDM5C lysine (K)-specific demethylase 5C
KDM7A lysine (K)-specific demethylase 7A
KPTN kaptin (actin binding protein)
LIME1 Lck interacting transmembrane adaptor 1
LOC390998 ribosomal protein L10 pseudogene
LTBP2 latent transforming growth factor beta binding protein 2
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAP1S microtubule-associated protein 1S
MAP3K2 mitogen-activated protein kinase kinase kinase 2
METTL21B methyltransferase like 21B
MMP9 matrix metallopeptidase 9
MRPL44 mitochondrial ribosomal protein L44
NPIPB3 nuclear pore complex interacting protein family, member B3
NT5E 5'-nucleotidase, ecto (CD73)
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
PACS1 phosphofurin acidic cluster sorting protein 1
PCDHGB5 protocadherin gamma subfamily B, 5
PIGN phosphatidylinositol glycan anchor biosynthesis, class N
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLTP phospholipid transfer protein
PODNL1 podocan-like 1
POLDIP2 polymerase (DNA-directed), delta interacting protein 2
POLH polymerase (DNA directed), eta
POM121 POM121 transmembrane nucleoporin
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta
PRR4 proline rich 4 (lacrimal)
PRSS22 protease, serine, 22
RIN2 Ras and Rab interactor 2
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RPL13P5 ribosomal protein L13 pseudogene 5
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SMIM14 small integral membrane protein 14
SNX16 sorting nexin 16
SSPN sarcospan
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TAOK1 TAO kinase 1
TEP1 telomerase-associated protein 1
TMEM212 transmembrane protein 212
USB1 U6 snRNA biogenesis 1
USP6 ubiquitin specific peptidase 6
XK X-linked Kx blood group
ZNF253 zinc finger protein 253
ZNF350 zinc finger protein 350
ZNF480 zinc finger protein 480
ZNF516 zinc finger protein 516
ZNF665 zinc finger protein 665
ZSCAN26 zinc finger and SCAN domain containing 26