amylocaine-1491 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the amylocaine-1491 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADAM22 ADAM metallopeptidase domain 22
ADAMTSL3 ADAMTS-like 3
AP3D1 adaptor-related protein complex 3, delta 1 subunit
APOC1 apolipoprotein C-I
ATF7IP activating transcription factor 7 interacting protein
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BCAM basal cell adhesion molecule (Lutheran blood group)
C18ORF25 chromosome 18 open reading frame 25
C1ORF95 chromosome 1 open reading frame 95
CD84 CD84 molecule
CDRT1 CMT1A duplicated region transcript 1
CFB complement factor B
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CLCF1 cardiotrophin-like cytokine factor 1
CLGN calmegin
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
DLC1 DLC1 Rho GTPase activating protein
DMPK dystrophia myotonica-protein kinase
DSC2 desmocollin 2
EGF epidermal growth factor
EHMT1 euchromatic histone-lysine N-methyltransferase 1
ENGASE endo-beta-N-acetylglucosaminidase
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
GMPR guanosine monophosphate reductase
GOSR2 golgi SNAP receptor complex member 2
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
ISG20 interferon stimulated exonuclease gene 20kDa
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KAT6B K(lysine) acetyltransferase 6B
KAZALD1 Kazal-type serine peptidase inhibitor domain 1
KCNJ14 potassium channel, inwardly rectifying subfamily J, member 14
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
LRP5L low density lipoprotein receptor-related protein 5-like
MAST2 microtubule associated serine/threonine kinase 2
MBD1 methyl-CpG binding domain protein 1
MCF2L MCF.2 cell line derived transforming sequence-like
MCM3AP minichromosome maintenance complex component 3 associated protein
MDM4 MDM4, p53 regulator
MED12 mediator complex subunit 12
MEF2C myocyte enhancer factor 2C
MID1 midline 1
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MNMIP1 manchette microtubule inner protein 1
MOCS1 molybdenum cofactor synthesis 1
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
N4BP2L2 NEDD4 binding protein 2-like 2
NDRG2 NDRG family member 2
NF2 neurofibromin 2 (merlin)
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NOS1 nitric oxide synthase 1 (neuronal)
OGFR opioid growth factor receptor
ONECUT1 one cut homeobox 1
OVOL2 ovo-like zinc finger 2
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PGR progesterone receptor
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PLAC1 placenta-specific 1
PLAGL1 pleiomorphic adenoma gene-like 1
PLIN2 perilipin 2
PMCHL1 pro-melanin-concentrating hormone-like 1, pseudogene
POFUT1 protein O-fucosyltransferase 1
PPAP2B phosphatidic acid phosphatase type 2B
PPARA peroxisome proliferator-activated receptor alpha
PSG9 pregnancy specific beta-1-glycoprotein 9
PTDSS2 phosphatidylserine synthase 2
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PTHLH parathyroid hormone-like hormone
PTPRA protein tyrosine phosphatase, receptor type, A
RAD54B RAD54 homolog B (S. cerevisiae)
RANBP3 RAN binding protein 3
RGS12 regulator of G-protein signaling 12
RNF122 ring finger protein 122
RNF170 ring finger protein 170
RNF208 ring finger protein 208
SCAI suppressor of cancer cell invasion
SCAPER S-phase cyclin A-associated protein in the ER
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SYN3 synapsin III
TAS2R1 taste receptor, type 2, member 1
TBC1D17 TBC1 domain family, member 17
TBCD tubulin folding cofactor D
THBS3 thrombospondin 3
TMEM259 transmembrane protein 259
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TPR translocated promoter region, nuclear basket protein
TRIM3 tripartite motif containing 3
XKR8 XK, Kell blood group complex subunit-related family, member 8
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZCCHC24 zinc finger, CCHC domain containing 24
ZMYM2 zinc finger, MYM-type 2
ZNF324 zinc finger protein 324
ZNF329 zinc finger protein 329

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ABLIM3 actin binding LIM protein family, member 3
ACSF2 acyl-CoA synthetase family member 2
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
AFAP1 actin filament associated protein 1
ARMC6 armadillo repeat containing 6
ARRB1 arrestin, beta 1
ASB9 ankyrin repeat and SOCS box containing 9
ATP7B ATPase, Cu++ transporting, beta polypeptide
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
C21ORF91 chromosome 21 open reading frame 91
C2ORF68 chromosome 2 open reading frame 68
CAPRIN2 caprin family member 2
CCDC69 coiled-coil domain containing 69
CCNL2 cyclin L2
CDK3 cyclin-dependent kinase 3
CDKL3 cyclin-dependent kinase-like 3
CLCN2 chloride channel, voltage-sensitive 2
CTC1 CTS telomere maintenance complex component 1
CUEDC1 CUE domain containing 1
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DEAF1 DEAF1 transcription factor
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
ENPEP glutamyl aminopeptidase (aminopeptidase A)
ETAA1 Ewing tumor-associated antigen 1
FGD1 FYVE, RhoGEF and PH domain containing 1
FRAT1 frequently rearranged in advanced T-cell lymphomas 1
GAB2 GRB2-associated binding protein 2
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GRTP1 growth hormone regulated TBC protein 1
HHLA3 HERV-H LTR-associating 3
HP1BP3 heterochromatin protein 1, binding protein 3
HSPA1L heat shock 70kDa protein 1-like
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
INO80D INO80 complex subunit D
IRF6 interferon regulatory factor 6
JADE3 jade family PHD finger 3
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KIFAP3 kinesin-associated protein 3
KLHL25 kelch-like family member 25
KRT86 keratin 86, type II
LYPLA2P1 lysophospholipase II pseudogene 1
LZTS3 leucine zipper, putative tumor suppressor family member 3
MOGS mannosyl-oligosaccharide glucosidase
MYL5 myosin, light chain 5, regulatory
NACAP1 nascent-polypeptide-associated complex alpha polypeptide pseudogene 1
NDE1 nudE neurodevelopment protein 1
NDRG4 NDRG family member 4
NOD1 nucleotide-binding oligomerization domain containing 1
NR1H2 nuclear receptor subfamily 1, group H, member 2
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OLFML3 olfactomedin-like 3
OSGIN1 oxidative stress induced growth inhibitor 1
P3H1 prolyl 3-hydroxylase 1
PACS1 phosphofurin acidic cluster sorting protein 1
PLEKHA6 pleckstrin homology domain containing, family A member 6
PLEKHO2 pleckstrin homology domain containing, family O member 2
PLIN3 perilipin 3
PRPH peripherin
PTK6 protein tyrosine kinase 6
PTPN9 protein tyrosine phosphatase, non-receptor type 9
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAD54L2 RAD54-like 2 (S. cerevisiae)
RBL1 retinoblastoma-like 1
RBM41 RNA binding motif protein 41
RIN2 Ras and Rab interactor 2
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RNF31 ring finger protein 31
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae)
SIX1 SIX homeobox 1
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8
SNX16 sorting nexin 16
SP1 Sp1 transcription factor
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
SYT17 synaptotagmin XVII
TMEM104 transmembrane protein 104
TNS2 tensin 2
TTC30A tetratricopeptide repeat domain 30A
UBQLN4 ubiquilin 4
VEGFB vascular endothelial growth factor B
VIPR1 vasoactive intestinal peptide receptor 1
VPS9D1 VPS9 domain containing 1
VWA9 von Willebrand factor A domain containing 9
WDR91 WD repeat domain 91
ZBTB22 zinc finger and BTB domain containing 22
ZNF205 zinc finger protein 205
ZNF250 zinc finger protein 250
ZNF747 zinc finger protein 747
ZSCAN9 zinc finger and SCAN domain containing 9