amyloidosis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description An acquired metabolic disease that involves abnormal deposited of amyloid proteins in organs and/or tissues. (Human Disease Ontology, DOID_9120)
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Genes

268 genes co-occuring with the disease amyloidosis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
TTR transthyretin 3.34292
SAA1 serum amyloid A1 2.70628
B2M beta-2-microglobulin 2.70509
APCS amyloid P component, serum 2.4959
LYZ lysozyme 2.48582
SAA2 serum amyloid A2 2.35976
GSN gelsolin 2.3169
MEFV Mediterranean fever 2.14226
APOE apolipoprotein E 1.93515
APP amyloid beta (A4) precursor protein 1.87194
CST3 cystatin C 1.86369
CSN1S1 casein alpha s1 1.79435
APOA2 apolipoprotein A-II 1.65295
APOA1 apolipoprotein A-I 1.63455
IAPP islet amyloid polypeptide 1.60234
ITM2B integral membrane protein 2B 1.49482
PSEN1 presenilin 1 1.432
CD79A CD79a molecule, immunoglobulin-associated alpha 1.39302
IGLV7-43 immunoglobulin lambda variable 7-43 1.37861
ALB albumin 1.36727
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 1.33589
OSMR oncostatin M receptor 1.30314
IL1RN interleukin 1 receptor antagonist 1.18798
PRNP prion protein 1.18669
CRP C-reactive protein, pentraxin-related 1.18453
TGFBI transforming growth factor, beta-induced, 68kDa 1.17292
LECT2 leukocyte cell-derived chemotaxin 2 1.17164
LPA lipoprotein, Lp(a) 1.15198
SAA4 serum amyloid A4, constitutive 1.14178
BACE1 beta-site APP-cleaving enzyme 1 1.07194
SDC2 syndecan 2 1.06942
MBTPS2 membrane-bound transcription factor peptidase, site 2 1.04588
TNNT2 troponin T type 2 (cardiac) 1.04377
MME membrane metallo-endopeptidase 1.01512
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 1.00077
ABRA actin binding Rho activating protein 0.99908
MAZ MYC-associated zinc finger protein (purine-binding transcription factor) 0.982636
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.949102
HSPB2 heat shock 27kDa protein 2 0.919673
CSTB cystatin B (stefin B) 0.89541
NLRP3 NLR family, pyrin domain containing 3 0.862228
FURIN furin (paired basic amino acid cleaving enzyme) 0.849945
RET ret proto-oncogene 0.844621
ALPPL2 alkaline phosphatase, placental-like 2 0.838885
ALPP alkaline phosphatase, placental 0.838476
ALPL alkaline phosphatase, liver/bone/kidney 0.838066
ERCC6L excision repair cross-complementation group 6-like 0.837246
IL1B interleukin 1, beta 0.806488
AGER advanced glycosylation end product-specific receptor 0.789262
IL31 interleukin 31 0.788442
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.775341
IDE insulin-degrading enzyme 0.773705
IL6 interleukin 6 0.769618
LDLR low density lipoprotein receptor 0.762271
EDEM3 ER degradation enhancer, mannosidase alpha-like 3 0.753306
FN1 fibronectin 1 0.74436
INS insulin 0.734622
ZDHHC13 zinc finger, DHHC-type containing 13 0.72612
MVK mevalonate kinase 0.705144
CST4 cystatin S 0.693499
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 0.691495
MAG myelin associated glycoprotein 0.674713
PAGE1 P antigen family, member 1 (prostate associated) 0.671527
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 0.664769
CD44 CD44 molecule (Indian blood group) 0.65288
CD68 CD68 molecule 0.627672
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 0.622183
TNF tumor necrosis factor 0.609276
KCNMB2 potassium channel subfamily M regulatory beta subunit 2 0.60069
LTF lactotransferrin 0.594454
CTSB cathepsin B 0.586665
APOA4 apolipoprotein A-IV 0.555956
FPR2 formyl peptide receptor 2 0.554403
PLG plasminogen 0.547032
CALCA calcitonin-related polypeptide alpha 0.544318
MAPT microtubule-associated protein tau 0.529994
ADAM10 ADAM metallopeptidase domain 10 0.528835
SLC30A3 solute carrier family 30 (zinc transporter), member 3 0.521117
F2 coagulation factor II (thrombin) 0.514571
NPPA natriuretic peptide A 0.501909
TACSTD2 tumor-associated calcium signal transducer 2 0.497321
HDX highly divergent homeobox 0.495411
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) 0.49274
DCN decorin 0.487407
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 0.487027
YARS tyrosyl-tRNA synthetase 0.477909
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 0.475255
CHST6 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6 0.470711
FBXO8 F-box protein 8 0.470711
CTSD cathepsin D 0.469197
GBAS glioblastoma amplified sequence 0.466928
SYP synaptophysin 0.453339
BGN biglycan 0.442418
PSEN2 presenilin 2 0.426265
PTH parathyroid hormone 0.42589
CHAT choline O-acetyltransferase 0.423265
PLAT plasminogen activator, tissue 0.418394
IL6R interleukin 6 receptor 0.413901
CRYAB crystallin, alpha B 0.413527
UNK unkempt family zinc finger 0.409414
CNTNAP4 contactin associated protein-like 4 0.403064
CLU clusterin 0.397471
ACE angiotensin I converting enzyme 0.396725
HLA-G major histocompatibility complex, class I, G 0.393001
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.391885
MMEL1 membrane metallo-endopeptidase-like 1 0.387051
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase 0.385193
SOD2 superoxide dismutase 2, mitochondrial 0.377031
CST6 cystatin E/M 0.372587
SLIRP SRA stem-loop interacting RNA binding protein 0.362239
F7 coagulation factor VII (serum prothrombin conversion accelerator) 0.355604
MGAT3 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase 0.344574
LRP2 low density lipoprotein receptor-related protein 2 0.344574
F10 coagulation factor X 0.339806
F9 coagulation factor IX 0.33066
MMP2 matrix metallopeptidase 2 0.3292
ZCWPW1 zinc finger, CW type with PWWP domain 1 0.328834
MYOCD myocardin 0.328834
LCAT lecithin-cholesterol acyltransferase 0.322637
AOC2 amine oxidase, copper containing 2 (retina-specific) 0.322273
GDF2 growth differentiation factor 2 0.318635
FBXL20 F-box and leucine-rich repeat protein 20 0.318635
ACHE acetylcholinesterase (Yt blood group) 0.318272
LGALS7B lectin, galactoside-binding, soluble, 7B 0.317909
CD38 CD38 molecule 0.312102
PGP phosphoglycolate phosphatase 0.311739
PCOLCE procollagen C-endopeptidase enhancer 0.302698
NPNT nephronectin 0.298011
DGKG diacylglycerol kinase, gamma 90kDa 0.297651
MMP1 matrix metallopeptidase 1 0.297291
C3 complement component 3 0.296211
CD34 CD34 molecule 0.296211
VWF von Willebrand factor 0.295132
HSPB8 heat shock 22kDa protein 8 0.294053
TSPO translocator protein (18kDa) 0.293694
GPM6A glycoprotein M6A 0.28294
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.27794
CLIC6 chloride intracellular channel 6 0.271886
PROS2P protein S (beta) pseudogene 0.269043
EARS2 glutamyl-tRNA synthetase 2, mitochondrial 0.268687
LEMD1 LEM domain containing 1 0.263014
GABPA GA binding protein transcription factor, alpha subunit 60kDa 0.260891
NCSTN nicastrin 0.260184
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.259477
RASD2 RASD family, member 2 0.259477
GCG glucagon 0.256652
MRAP melanocortin 2 receptor accessory protein 0.255946
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.255241
PLIN1 perilipin 1 0.252774
PIGN phosphatidylinositol glycan anchor biosynthesis, class N 0.250663
AOC3 amine oxidase, copper containing 3 0.24996
IGHV3-30 immunoglobulin heavy variable 3-30 0.24715
TNNI3 troponin I type 3 (cardiac) 0.246799
TGFB1 transforming growth factor, beta 1 0.245747
ANO5 anoctamin 5 0.243295
COLEC12 collectin sub-family member 12 0.241895
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.241895
GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa 0.238752
ALLC allantoicase 0.238403
ZNF165 zinc finger protein 165 0.236312
HP haptoglobin 0.233183
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A 0.233183
IGLV6-57 immunoglobulin lambda variable 6-57 0.232836
F8 coagulation factor VIII, procoagulant component 0.231102
BASP1 brain abundant, membrane attached signal protein 1 0.229024
CHI3L2 chitinase 3-like 2 0.229024
NID1 nidogen 1 0.229024
HPR haptoglobin-related protein 0.227642
AOAH acyloxyacyl hydrolase (neutrophil) 0.227297
PTPRM protein tyrosine phosphatase, receptor type, M 0.226607
F12 coagulation factor XII (Hageman factor) 0.222479
KRT5 keratin 5, type II 0.215314
DYSF dysferlin 0.214975
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 0.214636
AIF1 allograft inflammatory factor 1 0.210925
KRT14 keratin 14, type I 0.209248
MID1 midline 1 0.207245
BCHE butyrylcholinesterase 0.205916
AMICA1 adhesion molecule, interacts with CXADR antigen 1 0.204263
KNG1 kininogen 1 0.203275
GGT1 gamma-glutamyltransferase 1 0.202618
FPR3 formyl peptide receptor 3 0.19582
FTH1 ferritin, heavy polypeptide 1 0.195183
FTL ferritin, light polypeptide 0.195183
F3 coagulation factor III (thromboplastin, tissue factor) 0.194232
SLC30A5 solute carrier family 30 (zinc transporter), member 5 0.192971
NPHS1 nephrosis 1, congenital, Finnish type (nephrin) 0.192344
GNS glucosamine (N-acetyl)-6-sulfatase 0.191097
ELANE elastase, neutrophil expressed 0.190786
PDE1B phosphodiesterase 1B, calmodulin-dependent 0.188632
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 0.187415
OCLN occludin 0.185612
DGKE diacylglycerol kinase, epsilon 64kDa 0.184128
SST somatostatin 0.180367
IGKV1-17 immunoglobulin kappa variable 1-17 0.178403
NGF nerve growth factor (beta polypeptide) 0.175947
MAGEC1 melanoma antigen family C1 0.174354
NBEA neurobeachin 0.167224
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 0.165874
CASS4 Cas scaffolding protein family member 4 0.163317
CD19 CD19 molecule 0.160574
BDKRB1 bradykinin receptor B1 0.160387
TREX1 three prime repair exonuclease 1 0.158266
KRT16 keratin 16, type I 0.13986
KRT1 keratin 1, type II 0.13947
IL31RA interleukin 31 receptor A 0.139251
OSM oncostatin M 0.138256
EFNA5 ephrin-A5 0.136497
ASPN asporin 0.135901
CLDN5 claudin 5 0.135874
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 0.135764
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A 0.135218
LARGE like-glycosyltransferase 0.134244
MIXL1 Mix paired-like homeobox 0.133904
NOTCH3 notch 3 0.133881
A2M alpha-2-macroglobulin 0.133431
NOTCH4 notch 4 0.132946
ECE2 endothelin converting enzyme 2 0.132408
EZR ezrin 0.132106
NID2 nidogen 2 (osteonidogen) 0.131608
NOTO notochord homeobox 0.131549
SRF serum response factor (c-fos serum response element-binding transcription factor) 0.131205
NOS3 nitric oxide synthase 3 (endothelial cell) 0.130645
C1QTNF5 C1q and tumor necrosis factor related protein 5 0.129711
ATP5J ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6 0.129607
MRC1 mannose receptor, C type 1 0.129554
MEOX2 mesenchyme homeobox 2 0.129536
AQP1 aquaporin 1 (Colton blood group) 0.129234
MMP19 matrix metallopeptidase 19 0.128903
C1QB complement component 1, q subcomponent, B chain 0.128753
CASP5 caspase 5, apoptosis-related cysteine peptidase 0.128507
ACTA1 actin, alpha 1, skeletal muscle 0.128488
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) 0.12843
POLB polymerase (DNA directed), beta 0.12841
TJP1 tight junction protein 1 0.128176
MMP26 matrix metallopeptidase 26 0.127896
DAD1 defender against cell death 1 0.127174
LGMN legumain 0.126937
GPC1 glypican 1 0.126786
RETNLB resistin like beta 0.126609
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 0.126609
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast) 0.124897
GSTO1 glutathione S-transferase omega 1 0.124798
TXNDC9 thioredoxin domain containing 9 0.124264
TMSB10 thymosin beta 10 0.123896
COL2A1 collagen, type II, alpha 1 0.123712
FBN1 fibrillin 1 0.123223
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 0.122805
CR1 complement component (3b/4b) receptor 1 (Knops blood group) 0.122552
CA4 carbonic anhydrase IV 0.12128
AQP4 aquaporin 4 0.120784
CD40LG CD40 ligand 0.120722
SCARB1 scavenger receptor class B, member 1 0.119919
MMP9 matrix metallopeptidase 9 0.119587
KRT7 keratin 7, type II 0.118878
PTK2B protein tyrosine kinase 2 beta 0.117021
ENDOG endonuclease G 0.116418
NPPB natriuretic peptide B 0.114522
PPP2R4 protein phosphatase 2A activator, regulatory subunit 4 0.11448
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.113692
KCNJ13 potassium channel, inwardly rectifying subfamily J, member 13 0.113521
NME1 NME/NM23 nucleoside diphosphate kinase 1 0.113479
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 0.112004
DNTT DNA nucleotidylexotransferase 0.111823
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 0.111687
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3 0.111416
CAV2 caveolin 2 0.110775
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.109311