amyotrophic lateral sclerosis Gene Set

Dataset DISEASES Curated Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A motor neuron disease that is characterized by muscle spasticity, rapidly progressive weakness due to muscle atrophy, difficulty in speaking, swallowing, and breathing. (Human Disease Ontology, DOID_332)
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29 genes involed in the disease amyotrophic lateral sclerosis from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.

Symbol Name
ALS2 amyotrophic lateral sclerosis 2 (juvenile)
ANG angiogenin, ribonuclease, RNase A family, 5
ATF1 activating transcription factor 1
ATXN2 ataxin 2
C9ORF72 chromosome 9 open reading frame 72
CHCHD10 coiled-coil-helix-coiled-coil-helix domain containing 10
CHMP2B charged multivesicular body protein 2B
DCTN1 dynactin 1
ERBB4 erb-b2 receptor tyrosine kinase 4
FGGY FGGY carbohydrate kinase domain containing
FIG4 FIG4 phosphoinositide 5-phosphatase
FUS FUS RNA binding protein
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
MATR3 matrin 3
NEFH neurofilament, heavy polypeptide
OPTN optineurin
PFN1 profilin 1
PRPH peripherin
SETX senataxin
SIGMAR1 sigma non-opioid intracellular receptor 1
SMN1 survival of motor neuron 1, telomeric
SOD1 superoxide dismutase 1, soluble
SPG11 spastic paraplegia 11 (autosomal recessive)
TARDBP TAR DNA binding protein
TMEM106B transmembrane protein 106B
TRPM7 transient receptor potential cation channel, subfamily M, member 7
UBQLN2 ubiquilin 2
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C
VCP valosin containing protein