anaphase-promoting complex Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B. (Gene Ontology, GO_0005680)
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Genes

192 proteins co-occuring with the anaphase-promoting complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
CDC20 cell division cycle 20 3.61737
PTTG1 pituitary tumor-transforming 1 2.52485
CDC27 cell division cycle 27 2.3368
FBXO5 F-box protein 5 2.28611
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 2.09182
ANAPC11 anaphase promoting complex subunit 11 1.95512
CCNB1 cyclin B1 1.93553
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 1.92647
CDC16 cell division cycle 16 1.91395
PARK2 parkin RBR E3 ubiquitin protein ligase 1.91118
FBXO43 F-box protein 43 1.87175
ANAPC5 anaphase promoting complex subunit 5 1.87175
CDC23 cell division cycle 23 1.86486
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae) 1.75981
BUB3 BUB3 mitotic checkpoint protein 1.72369
CDK1 cyclin-dependent kinase 1 1.71435
ANAPC10 anaphase promoting complex subunit 10 1.68665
PLK1 polo-like kinase 1 1.60885
ANAPC4 anaphase promoting complex subunit 4 1.58852
SKP1 S-phase kinase-associated protein 1 1.58507
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase 1.56162
UBE2S ubiquitin-conjugating enzyme E2S 1.55934
UBE2K ubiquitin-conjugating enzyme E2K 1.37962
CDC14A cell division cycle 14A 1.32871
BUB1 BUB1 mitotic checkpoint serine/threonine kinase 1.30927
CUL1 cullin 1 1.28516
GMNN geminin, DNA replication inhibitor 1.26022
MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast) 1.22412
UBE2H ubiquitin-conjugating enzyme E2H 1.20653
CDC26 cell division cycle 26 1.17414
ANAPC13 anaphase promoting complex subunit 13 1.12501
UBE2D2 ubiquitin-conjugating enzyme E2D 2 1.11582
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 1.11327
WEE1 WEE1 G2 checkpoint kinase 1.10053
UBE2C ubiquitin-conjugating enzyme E2C 1.09696
USP44 ubiquitin specific peptidase 44 1.0253
CDK2 cyclin-dependent kinase 2 1.02281
AURKB aurora kinase B 0.985367
CUEDC2 CUE domain containing 2 0.980016
ANAPC2 anaphase promoting complex subunit 2 0.872726
CDC34 cell division cycle 34 0.854339
EVI5 ecotropic viral integration site 5 0.852042
CDC6 cell division cycle 6 0.846073
ANAPC7 anaphase promoting complex subunit 7 0.836433
PPP2R4 protein phosphatase 2A activator, regulatory subunit 4 0.836433
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 0.827254
ANAPC16 anaphase promoting complex subunit 16 0.817616
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.81257
TRIM39-RPP21 TRIM39-RPP21 readthrough 0.802479
PLK2 polo-like kinase 2 0.796062
SGOL1 shugoshin-like 1 (S. pombe) 0.787359
UBE2E3 ubiquitin-conjugating enzyme E2E 3 0.771363
CENPE centromere protein E, 312kDa 0.755437
UBE2D4 ubiquitin-conjugating enzyme E2D 4 (putative) 0.754983
TRIM39 tripartite motif containing 39 0.745025
USP37 ubiquitin specific peptidase 37 0.733319
CDC25C cell division cycle 25C 0.71857
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.717236
UBE2A ubiquitin-conjugating enzyme E2A 0.713238
CDCA5 cell division cycle associated 5 0.709693
RAE1 ribonucleic acid export 1 0.67246
UBE2T ubiquitin-conjugating enzyme E2T 0.668559
USE1 unconventional SNARE in the ER 1 homolog (S. cerevisiae) 0.654311
RNF31 ring finger protein 31 0.648291
UBE2L3 ubiquitin-conjugating enzyme E2L 3 0.63544
CKAP2L cytoskeleton associated protein 2-like 0.61968
CDT1 chromatin licensing and DNA replication factor 1 0.613318
CASC1 cancer susceptibility candidate 1 0.612895
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.606973
FBXO4 F-box protein 4 0.602331
HECTD3 HECT domain containing E3 ubiquitin protein ligase 3 0.595593
UBE2I ubiquitin-conjugating enzyme E2I 0.593072
CDCA3 cell division cycle associated 3 0.586361
FBXW8 F-box and WD repeat domain containing 8 0.583431
CCAR1 cell division cycle and apoptosis regulator 1 0.580086
MAD2L1BP MAD2L1 binding protein 0.572994
TRIP13 thyroid hormone receptor interactor 13 0.558042
NUP98 nucleoporin 98kDa 0.548535
ANAPC1 anaphase promoting complex subunit 1 0.524294
TP53 tumor protein p53 0.516532
UBE3A ubiquitin protein ligase E3A 0.514493
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 0.513677
UBA1 ubiquitin-like modifier activating enzyme 1 0.511233
TK1 thymidine kinase 1, soluble 0.490135
KLHL3 kelch-like family member 3 0.488519
SPRTN SprT-like N-terminal domain 0.485289
CCNA2 cyclin A2 0.484886
MIIP migration and invasion inhibitory protein 0.48287
SPATC1 spermatogenesis and centriole associated 1 0.473617
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 0.472011
TRIM69 tripartite motif containing 69 0.462798
HOXC10 homeobox C10 0.461599
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase 0.448848
UBE2G2 ubiquitin-conjugating enzyme E2G 2 0.444085
TPR translocated promoter region, nuclear basket protein 0.443689
FAM64A family with sequence similarity 64, member A 0.441312
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) 0.434591
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.432224
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 0.427104
CDC25A cell division cycle 25A 0.414164
MASTL microtubule associated serine/threonine kinase-like 0.413773
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.411039
UBE3C ubiquitin protein ligase E3C 0.404804
NKX6-1 NK6 homeobox 1 0.404415
GRWD1 glutamate-rich WD repeat containing 1 0.400527
AURKA aurora kinase A 0.395485
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3) 0.386979
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon 0.385436
KIF18A kinesin family member 18A 0.383124
USP39 ubiquitin specific peptidase 39 0.381584
CHEK1 checkpoint kinase 1 0.381199
MIS12 MIS12 kinetochore complex component 0.378507
FBXW5 F-box and WD repeat domain containing 5 0.378122
COPS3 COP9 signalosome subunit 3 0.371982
CDC25B cell division cycle 25B 0.358609
PLCZ1 phospholipase C, zeta 1 0.355563
DTYMK deoxythymidylate kinase (thymidylate kinase) 0.352522
MOAP1 modulator of apoptosis 1 0.349484
BIRC6 baculoviral IAP repeat containing 6 0.348346
MPEG1 macrophage expressed 1 0.347587
BRSK2 BR serine/threonine kinase 2 0.346071
DBF4 DBF4 zinc finger 0.344556
MAK male germ cell-associated kinase 0.341907
WEE2 WEE1 homolog 2 (S. pombe) 0.334356
PRCC papillary renal cell carcinoma (translocation-associated) 0.333979
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa 0.333225
UBE2N ubiquitin-conjugating enzyme E2N 0.328332
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 0.319702
E2F7 E2F transcription factor 7 0.313344
TUBGCP3 tubulin, gamma complex associated protein 3 0.30626
MDC1 mediator of DNA-damage checkpoint 1 0.304771
RAD18 RAD18 E3 ubiquitin protein ligase 0.302912
INVS inversin 0.300311
PDCD2 programmed cell death 2 0.299569
EPT1 ethanolaminephosphotransferase 1 0.299569
AURKAIP1 aurora kinase A interacting protein 1 0.281821
KIFC1 kinesin family member C1 0.280716
CKAP2 cytoskeleton associated protein 2 0.276671
CDC5L cell division cycle 5-like 0.275202
NEUROD2 neuronal differentiation 2 0.271533
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 0.265677
MCPH1 microcephalin 1 0.264581
PHF8 PHD finger protein 8 0.26312
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 0.258381
HOXD10 homeobox D10 0.253291
FAN1 FANCD2/FANCI-associated nuclease 1 0.250751
METTL13 methyltransferase like 13 0.249664
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.24713
HELZ helicase with zinc finger 0.246407
GLS glutaminase 0.246407
FLI1 Fli-1 proto-oncogene, ETS transcription factor 0.239197
RNF6 ring finger protein (C3H2C3 type) 6 0.236683
IL17RC interleukin 17 receptor C 0.235966
PPP1R10 protein phosphatase 1, regulatory subunit 10 0.235966
RAD21 RAD21 homolog (S. pombe) 0.232386
LUZP6 leucine zipper protein 6 0.232029
SSU72 SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae) 0.230601
CCNE1 cyclin E1 0.229176
CLTA clathrin, light chain A 0.228819
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.227397
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 0.224913
CCNB2 cyclin B2 0.224558
GTSE1 G-2 and S-phase expressed 1 0.224558
SMC3 structural maintenance of chromosomes 3 0.223497
TRRAP transformation/transcription domain-associated protein 0.217861
TACC3 transforming, acidic coiled-coil containing protein 3 0.215063
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.215063
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.21228
NINL ninein-like 0.208825
FOXG1 forkhead box G1 0.205059
ATR ATR serine/threonine kinase 0.204378
MCM2 minichromosome maintenance complex component 2 0.201335
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.194045
SMAD3 SMAD family member 3 0.192423
CENPA centromere protein A 0.190814
NPHP3 nephronophthisis 3 (adolescent) 0.188905
SLC39A2 solute carrier family 39 (zinc transporter), member 2 0.184241
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.183025
KIF4A kinesin family member 4A 0.181823
SKA3 spindle and kinetochore associated complex subunit 3 0.178877
MAST4 microtubule associated serine/threonine kinase family member 4 0.178588
MCM7 minichromosome maintenance complex component 7 0.177154
CYCS cytochrome c, somatic 0.170888
ZW10 zw10 kinetochore protein 0.170114
NDC80 NDC80 kinetochore complex component 0.168847
BRD7 bromodomain containing 7 0.167125
LINGO1 leucine rich repeat and Ig domain containing 1 0.166643
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.165231
UBE2B ubiquitin-conjugating enzyme E2B 0.162117
CUL7 cullin 7 0.159074
NEK2 NIMA-related kinase 2 0.156513
EYA1 EYA transcriptional coactivator and phosphatase 1 0.156513