aneurysm Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description Abnormal outpouching or sac-like dilatation in the wall of an atery, vein or the heart. (Human Phenotype Ontology, HP_0002617)
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Genes

139 genes co-occuring with the biological term aneurysm in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ABHD16A abhydrolase domain containing 16A
ACE angiotensin I converting enzyme
ACTA2 actin, alpha 2, smooth muscle, aorta
ADIPOQ adiponectin, C1Q and collagen domain containing
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
ANGPT2 angiopoietin 2
ANGPTL2 angiopoietin-like 2
APOA1 apolipoprotein A-I
APOB apolipoprotein B
APOE apolipoprotein E
APOM apolipoprotein M
BAG6 BCL2-associated athanogene 6
BIRC5 baculoviral IAP repeat containing 5
CA1 carbonic anhydrase I
CAPN2 calpain 2, (m/II) large subunit
CASP3 caspase 3, apoptosis-related cysteine peptidase
CCL22 chemokine (C-C motif) ligand 22
CCL5 chemokine (C-C motif) ligand 5
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD14 CD14 molecule
CD4 CD4 molecule
CD44 CD44 molecule (Indian blood group)
CD59 CD59 molecule, complement regulatory protein
CD68 CD68 molecule
CDKN2B-AS1 CDKN2B antisense RNA 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLU clusterin
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CRP C-reactive protein, pentraxin-related
CSF3 colony stimulating factor 3 (granulocyte)
CTGF connective tissue growth factor
CTSB cathepsin B
CTSS cathepsin S
CXCL8 chemokine (C-X-C motif) ligand 8
EDN1 endothelin 1
EDNRA endothelin receptor type A
EGR1 early growth response 1
ELN elastin
ENG endoglin
FBLN5 fibulin 5
FBN1 fibrillin 1
FBN2 fibrillin 2
FGF1 fibroblast growth factor 1 (acidic)
FGF2 fibroblast growth factor 2 (basic)
FLT1 fms-related tyrosine kinase 1
FN1 fibronectin 1
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HMGB1 high mobility group box 1
HMOX1 heme oxygenase 1
HOXA4 homeobox A4
HPSE heparanase
HSPA4 heat shock 70kDa protein 4
HSPB1 heat shock 27kDa protein 1
HSPG2 heparan sulfate proteoglycan 2
IGFBP1 insulin-like growth factor binding protein 1
IGFBP3 insulin-like growth factor binding protein 3
IL10 interleukin 10
IL12A interleukin 12A
IL12B interleukin 12B
IL17A interleukin 17A
IL23A interleukin 23, alpha subunit p19
IL2RA interleukin 2 receptor, alpha
IL6 interleukin 6
ITPKC inositol-trisphosphate 3-kinase C
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JDP2 Jun dimerization protein 2
KDR kinase insert domain receptor
KLF15 Kruppel-like factor 15
KLK1 kallikrein 1
LCN2 lipocalin 2
LDLR low density lipoprotein receptor
LEP leptin
LIMK1 LIM domain kinase 1
LOX lysyl oxidase
LRP1 low density lipoprotein receptor-related protein 1
LTBP4 latent transforming growth factor beta binding protein 4
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MFAP5 microfibrillar associated protein 5
MIR21 microRNA 21
MIR29A microRNA 29a
MIR34B microRNA 34b
MIR34C microRNA 34c
MMP10 matrix metallopeptidase 10
MMP2 matrix metallopeptidase 2
MMP8 matrix metallopeptidase 8
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MYH11 myosin, heavy chain 11, smooth muscle
NF1 neurofibromin 1
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH1 notch 1
NPPB natriuretic peptide B
NTM neurotrimin
PF4 platelet factor 4
PLA2G10 phospholipase A2, group X
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLAT plasminogen activator, tissue
PPARG peroxisome proliferator-activated receptor gamma
PRDX1 peroxiredoxin 1
PRF1 perforin 1 (pore forming protein)
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PRRC2A proline-rich coiled-coil 2A
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RETN resistin
RTN4 reticulon 4
S100A12 S100 calcium binding protein A12
SELE selectin E
SERBP1 SERPINE1 mRNA binding protein 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SMAD2 SMAD family member 2
SORT1 sortilin 1
SOX17 SRY (sex determining region Y)-box 17
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TGFB1 transforming growth factor, beta 1
TGFB2 transforming growth factor, beta 2
TGFBR1 transforming growth factor, beta receptor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TIMP1 TIMP metallopeptidase inhibitor 1
TIMP2 TIMP metallopeptidase inhibitor 2
TIMP3 TIMP metallopeptidase inhibitor 3
TNC tenascin C
TNF tumor necrosis factor
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TP53 tumor protein p53
TPSAB1 tryptase alpha/beta 1
VCAN versican
XYLT1 xylosyltransferase I