anoikis Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description Apoptosis triggered by inadequate or inappropriate adherence to substrate e.g. after disruption of the interactions between normal epithelial cells and the extracellular matrix. (Gene Ontology, GO_0043276)
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Genes

134 genes co-occuring with the biological term anoikis in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABHD4 abhydrolase domain containing 4
AFAP1L1 actin filament associated protein 1-like 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
ANGPTL4 angiopoietin-like 4
BAX BCL2-associated X protein
BCAR1 breast cancer anti-estrogen resistance 1
BCL2 B-cell CLL/lymphoma 2
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BIRC3 baculoviral IAP repeat containing 3
BMF Bcl2 modifying factor
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA2 breast cancer 2, early onset
BSG basigin (Ok blood group)
CALR calreticulin
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CCAR2 cell cycle and apoptosis regulator 2
CD63 CD63 molecule
CDCP1 CUB domain containing protein 1
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKN2A cyclin-dependent kinase inhibitor 2A
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHUK conserved helix-loop-helix ubiquitous kinase
CLDN1 claudin 1
CLU clusterin
CMA1 chymase 1, mast cell
COPS5 COP9 signalosome subunit 5
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CSPG4 chondroitin sulfate proteoglycan 4
CTNND1 catenin (cadherin-associated protein), delta 1
CTTN cortactin
CXCL12 chemokine (C-X-C motif) ligand 12
DAP3 death associated protein 3
DAPK1 death-associated protein kinase 1
DLG1 discs, large homolog 1 (Drosophila)
EDA2R ectodysplasin A2 receptor
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
EEF2K eukaryotic elongation factor 2 kinase
EGFR epidermal growth factor receptor
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
ERBB4 erb-b2 receptor tyrosine kinase 4
FER fer (fps/fes related) tyrosine kinase
FGF2 fibroblast growth factor 2 (basic)
FN1 fibronectin 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HK2 hexokinase 2
HMCN1 hemicentin 1
HMGA1 high mobility group AT-hook 1
HOXA10 homeobox A10
HTRA1 HtrA serine peptidase 1
IGF1R insulin-like growth factor 1 receptor
IKZF3 IKAROS family zinc finger 3 (Aiolos)
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGA6 integrin, alpha 6
ITGA8 integrin, alpha 8
ITGAV integrin, alpha V
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
KDR kinase insert domain receptor
KL klotho
KRAS Kirsten rat sarcoma viral oncogene homolog
LGALS1 lectin, galactoside-binding, soluble, 1
LRP1 low density lipoprotein receptor-related protein 1
LTB4R2 leukotriene B4 receptor 2
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAVS mitochondrial antiviral signaling protein
MCL1 myeloid cell leukemia 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MET MET proto-oncogene, receptor tyrosine kinase
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
MIR200C microRNA 200c
MMP11 matrix metallopeptidase 11
MMP13 matrix metallopeptidase 13
MMP2 matrix metallopeptidase 2
MTA1 metastasis associated 1
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYBBP1A MYB binding protein (P160) 1a
NRP1 neuropilin 1
NTF3 neurotrophin 3
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OLFM3 olfactomedin 3
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PECAM1 platelet/endothelial cell adhesion molecule 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PLK1 polo-like kinase 1
PRKCA protein kinase C, alpha
PRKD1 protein kinase D1
PTEN phosphatase and tensin homolog
PTHLH parathyroid hormone-like hormone
PTK2 protein tyrosine kinase 2
PTK2B protein tyrosine kinase 2 beta
PTK6 protein tyrosine kinase 6
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTRH2 peptidyl-tRNA hydrolase 2
RAD9A RAD9 homolog A (S. pombe)
RHOA ras homolog family member A
RHOC ras homolog family member C
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
S100A4 S100 calcium binding protein A4
SCRIB scribbled planar cell polarity protein
SH3GLB1 SH3-domain GRB2-like endophilin B1
SIK1 salt-inducible kinase 1
SIRPA signal-regulatory protein alpha
SIRT3 sirtuin 3
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SMAD4 SMAD family member 4
SNAI2 snail family zinc finger 2
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STK11 serine/threonine kinase 11
TAGLN transgelin
TGFB1 transforming growth factor, beta 1
THBS1 thrombospondin 1
TIMP1 TIMP metallopeptidase inhibitor 1
TP53 tumor protein p53
TPM1 tropomyosin 1 (alpha)
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
USP9X ubiquitin specific peptidase 9, X-linked
WISP3 WNT1 inducible signaling pathway protein 3
WNT2 wingless-type MMTV integration site family member 2
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta