apaf1 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description apoptotic peptidase activating factor 1|This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 317)
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Genes

40 genes co-occuring with the biological term apaf1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AIP aryl hydrocarbon receptor interacting protein
AKT1 v-akt murine thymoma viral oncogene homolog 1
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
APAF1 apoptotic peptidase activating factor 1
APIP APAF1 interacting protein
BAD BCL2-associated agonist of cell death
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BID BH3 interacting domain death agonist
BIRC5 baculoviral IAP repeat containing 5
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CSE1L CSE1 chromosome segregation 1-like (yeast)
DAPK1 death-associated protein kinase 1
E2F1 E2F transcription factor 1
E2F6 E2F transcription factor 6
ENDOG endonuclease G
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAS Fas cell surface death receptor
GPI glucose-6-phosphate isomerase
HDAC2 histone deacetylase 2
HSPA4 heat shock 70kDa protein 4
IL24 interleukin 24
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
MCL1 myeloid cell leukemia 1
NLRC4 NLR family, CARD domain containing 4
PARP1 poly (ADP-ribose) polymerase 1
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PTMA prothymosin, alpha
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SOD1 superoxide dismutase 1, soluble
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TP53 tumor protein p53
TPT1 tumor protein, translationally-controlled 1
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta