apc Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B. (Gene Ontology, GO_0005680)
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Genes

168 genes co-occuring with the biological term apc in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ACVR1 activin A receptor, type I
AKT1 v-akt murine thymoma viral oncogene homolog 1
AMER1 APC membrane recruitment protein 1
ANAPC7 anaphase promoting complex subunit 7
APC adenomatous polyposis coli
APC2 adenomatosis polyposis coli 2
APOH apolipoprotein H (beta-2-glycoprotein I)
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4
ATF1 activating transcription factor 1
AURKB aurora kinase B
AXIN1 axin 1
AXIN2 axin 2
BCL2 B-cell CLL/lymphoma 2
BIRC5 baculoviral IAP repeat containing 5
BRAF B-Raf proto-oncogene, serine/threonine kinase
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
CASR calcium-sensing receptor
CAV1 caveolin 1, caveolae protein, 22kDa
CCNA2 cyclin A2
CCND1 cyclin D1
CD274 CD274 molecule
CD37 CD37 molecule
CDC27 cell division cycle 27
CDC42 cell division cycle 42
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK2 cyclin-dependent kinase 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CDX2 caudal type homeobox 2
CLEC7A C-type lectin domain family 7, member A
CLU clusterin
CPB2 carboxypeptidase B2 (plasma)
CTBP1 C-terminal binding protein 1
CTBP2 C-terminal binding protein 2
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTNNBIP1 catenin, beta interacting protein 1
CTSA cathepsin A
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila)
DCC DCC netrin 1 receptor
DCLRE1A DNA cross-link repair 1A
DCTN1 dynactin 1
DHRS9 dehydrogenase/reductase (SDR family) member 9
DLG1 discs, large homolog 1 (Drosophila)
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DNMT1 DNA (cytosine-5-)-methyltransferase 1
EGFR epidermal growth factor receptor
ERBB2IP erbb2 interacting protein
ERBB3 erb-b2 receptor tyrosine kinase 3
ESR1 estrogen receptor 1
F10 coagulation factor X
F2 coagulation factor II (thrombin)
F2R coagulation factor II (thrombin) receptor
F5 coagulation factor V (proaccelerin, labile factor)
F8 coagulation factor VIII, procoagulant component
FASLG Fas ligand (TNF superfamily, member 6)
FBXO5 F-box protein 5
FEN1 flap structure-specific endonuclease 1
FHIT fragile histidine triad
FOXP3 forkhead box P3
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GP1BA glycoprotein Ib (platelet), alpha polypeptide
GPNMB glycoprotein (transmembrane) nmb
GSK3B glycogen synthase kinase 3 beta
GSTP1 glutathione S-transferase pi 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HRAS Harvey rat sarcoma viral oncogene homolog
ICOS inducible T-cell co-stimulator
IDO1 indoleamine 2,3-dioxygenase 1
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IL27 interleukin 27
IL6 interleukin 6
IQGAP1 IQ motif containing GTPase activating protein 1
IST1 increased sodium tolerance 1 homolog (yeast)
JAK2 Janus kinase 2
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KLF4 Kruppel-like factor 4 (gut)
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT14 keratin 14, type I
KRT8 keratin 8, type II
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPRE1 microtubule-associated protein, RP/EB family, member 1
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MAPRE3 microtubule-associated protein, RP/EB family, member 3
MARK2 MAP/microtubule affinity-regulating kinase 2
MCC mutated in colorectal cancers
MGMT O-6-methylguanine-DNA methyltransferase
MIR135A1 microRNA 135a-1
MIR142 microRNA 142
MIR143 microRNA 143
MIR155 microRNA 155
MIR205 microRNA 205
MIR21 microRNA 21
MLH1 mutL homolog 1
MLH3 mutL homolog 3
MMP2 matrix metallopeptidase 2
MSH2 mutS homolog 2
MSI1 musashi RNA-binding protein 1
MUC2 mucin 2, oligomeric mucus/gel-forming
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MUTYH mutY homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAV2 neuron navigator 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NIN ninein (GSK3B interacting protein)
NRIP1 nuclear receptor interacting protein 1
OSM oncostatin M
OSMR oncostatin M receptor
PARK2 parkin RBR E3 ubiquitin protein ligase
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
POLB polymerase (DNA directed), beta
PPP1R9B protein phosphatase 1, regulatory subunit 9B
PRKCD protein kinase C, delta
PRKCQ protein kinase C, theta
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PROCR protein C receptor, endothelial
PROS1 protein S (alpha)
PTEN phosphatase and tensin homolog
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa
PTGES prostaglandin E synthase
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RANBP2 RAN binding protein 2
RARB retinoic acid receptor, beta
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RB1CC1 RB1-inducible coiled-coil 1
SCIMP SLP adaptor and CSK interacting membrane protein
SCRIB scribbled planar cell polarity protein
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP2 secreted frizzled-related protein 2
SFRP4 secreted frizzled-related protein 4
SFRP5 secreted frizzled-related protein 5
SMS spermine synthase
SPATA13 spermatogenesis associated 13
SRSF1 serine/arginine-rich splicing factor 1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STIM1 stromal interaction molecule 1
STIP1 stress-induced phosphoprotein 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TEK TEK tyrosine kinase, endothelial
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFB1 transforming growth factor, beta 1
THBD thrombomodulin
TNF tumor necrosis factor
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TP53BP1 tumor protein p53 binding protein 1
USP44 ubiquitin specific peptidase 44
WIF1 WNT inhibitory factor 1
WNT1 wingless-type MMTV integration site family, member 1
WNT5A wingless-type MMTV integration site family, member 5A