apical junction complex Gene Set

Dataset GO Cellular Component Annotations 2025
Category structural or functional annotations
Type cellular component
Description A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in some invertebrates, such as Drosophila, is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability. (Gene Ontology, GO_0043296)
External Link http://amigo.geneontology.org/amigo/term/GO:0043296
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Genes

108 proteins localized to the apical junction complex cellular component from the curated GO Cellular Component Annotations 2025 dataset.

Symbol Name
ACTG1 actin gamma 1
AJM1 apical junction component 1 homolog
AMOT angiomotin
AMOTL1 angiomotin like 1
AMOTL2 angiomotin like 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
AOC1 amine oxidase, copper containing 1
BVES blood vessel epicardial substance
CAMSAP3 calmodulin regulated spectrin-associated protein family, member 3
CCDC85C coiled-coil domain containing 85C
CDH5 cadherin 5, type 2 (vascular endothelium)
CGN cingulin
CGNL1 cingulin-like 1
CLDN1 claudin 1
CLDN10 claudin 10
CLDN11 claudin 11
CLDN12 claudin 12
CLDN14 claudin 14
CLDN15 claudin 15
CLDN16 claudin 16
CLDN17 claudin 17
CLDN18 claudin 18
CLDN19 claudin 19
CLDN2 claudin 2
CLDN20 claudin 20
CLDN22 claudin 22
CLDN23 claudin 23
CLDN24 claudin 24
CLDN25 claudin 25
CLDN3 claudin 3
CLDN34 claudin 34
CLDN4 claudin 4
CLDN5 claudin 5
CLDN6 claudin 6
CLDN7 claudin 7
CLDN8 claudin 8
CLDN9 claudin 9
CLMP CXADR-like membrane protein
CRB1 crumbs family member 1, photoreceptor morphogenesis associated
CRB2 crumbs family member 2
CRB3 crumbs family member 3
CXADR coxsackie virus and adenovirus receptor
CYTH1 cytohesin 1
CYTH3 cytohesin 3
DLG1 discs, large homolog 1 (Drosophila)
ECT2 epithelial cell transforming 2
EPCAM epithelial cell adhesion molecule
EPPK1 epiplakin 1
F11R F11 receptor
FBF1 Fas (TNFRSF6) binding factor 1
FRMD4A FERM domain containing 4A
FRMD4B FERM domain containing 4B
FRMPD2 FERM and PDZ domain containing 2
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
IGSF5 immunoglobulin superfamily, member 5
JAM3 junctional adhesion molecule 3
JAML junction adhesion molecule like
JUP junction plakoglobin
KIFC3 kinesin family member C3
LNX1 ligand of numb-protein X 1, E3 ubiquitin protein ligase
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2
MARVELD2 MARVEL domain containing 2
MARVELD3 MARVEL domain containing 3
MICALL2 MICAL-like 2
MPP7 membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
MTDH metadherin
NECTIN2 nectin cell adhesion molecule 2
NECTIN3 nectin cell adhesion molecule 3
NHERF4 NHERF family PDZ scaffold protein 4
OCEL1 occludin/ELL domain containing 1
OCLN occludin
PALS1 protein associated with LIN7 1, MAGUK p55 family member
PARD3 par-3 family cell polarity regulator
PARD3B par-3 family cell polarity regulator beta
PARD6A par-6 family cell polarity regulator alpha
PARD6B par-6 family cell polarity regulator beta
PATJ PATJ crumbs cell polarity complex component
PKN2 protein kinase N2
PLEKHA7 pleckstrin homology domain containing, family A member 7
POF1B premature ovarian failure, 1B
POTEF POTE ankyrin domain family, member F
PROC protein C (inactivator of coagulation factors Va and VIIIa)
RAB13 RAB13, member RAS oncogene family
RAP2B RAP2B, member of RAS oncogene family
RAP2C RAP2C, member of RAS oncogene family
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RHOA ras homolog family member A
RIGI RNA sensor RIG-I
SAPCD2 suppressor APC domain containing 2
SH3BP1 SH3-domain binding protein 1
SHROOM1 shroom family member 1
SHROOM2 shroom family member 2
SHROOM3 shroom family member 3
SHROOM4 shroom family member 4
SORBS1 sorbin and SH3 domain containing 1
STRN striatin, calmodulin binding protein
TBCD tubulin folding cofactor D
TGFBR1 transforming growth factor, beta receptor 1
TJP1 tight junction protein 1
TJP2 tight junction protein 2
TJP3 tight junction protein 3
UBN1 ubinuclein 1
USP53 ubiquitin specific peptidase 53
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
VCL vinculin
WNK3 WNK lysine deficient protein kinase 3
WNK4 WNK lysine deficient protein kinase 4
YBX3 Y box binding protein 3