apob Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description apolipoprotein B|This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 338)
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Genes

45 genes co-occuring with the biological term apob in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANGPTL3 angiopoietin-like 3
APOA1 apolipoprotein A-I
APOA2 apolipoprotein A-II
APOA4 apolipoprotein A-IV
APOB apolipoprotein B
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
APOC2 apolipoprotein C-II
APOC3 apolipoprotein C-III
APOE apolipoprotein E
APOM apolipoprotein M
BAG4 BCL2-associated athanogene 4
CELF2 CUGBP, Elav-like family member 2
CETP cholesteryl ester transfer protein, plasma
DERL1 derlin 1
DPP4 dipeptidyl-peptidase 4
EGF epidermal growth factor
ETM2 essential tremor 2
FAF2 Fas associated factor family member 2
HNF1A HNF1 homeobox A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
IRS1 insulin receptor substrate 1
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
LDLR low density lipoprotein receptor
LEP leptin
LIPG lipase, endothelial
LPA lipoprotein, Lp(a)
LPL lipoprotein lipase
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MTTP microsomal triglyceride transfer protein
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
PCSK9 proprotein convertase subtilisin/kexin type 9
PDIA3 protein disulfide isomerase family A, member 3
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PON1 paraoxonase 1
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RETN resistin
SAA4 serum amyloid A4, constitutive
SCARB1 scavenger receptor class B, member 1
SOAT1 sterol O-acyltransferase 1
SREBF1 sterol regulatory element binding transcription factor 1
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast)
VCP valosin containing protein
VLDLR very low density lipoprotein receptor