apoptotic process Gene Set

Dataset GO Biological Process Annotations 2025
Category structural or functional annotations
Type biological process
Description A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. (Gene Ontology, GO_0006915)
External Link http://amigo.geneontology.org/amigo/term/GO:0006915
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Genes

233 genes participating in the apoptotic process biological process from the curated GO Biological Process Annotations 2025 dataset.

Symbol Name
ADAM15 ADAM metallopeptidase domain 15
ADORA2A adenosine A2a receptor
ADRA1A adrenoceptor alpha 1A
AHCYL1 adenosylhomocysteinase-like 1
AHR aryl hydrocarbon receptor
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1
AIFM2 apoptosis-inducing factor, mitochondrion-associated, 2
AKAP1 A kinase (PRKA) anchor protein 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALOX15B arachidonate 15-lipoxygenase, type B
APAF1 apoptotic peptidase activating factor 1
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ATCAY ataxia, cerebellar, Cayman type
ATN1 atrophin 1
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
BAD BCL2-associated agonist of cell death
BAG6 BCL2-associated athanogene 6
BAK1 BCL2-antagonist/killer 1
BAX BCL2-associated X protein
BBC3 BCL2 binding component 3
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BCL2L10 BCL2-like 10 (apoptosis facilitator)
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCL2L13 BCL2-like 13 (apoptosis facilitator)
BCL2L14 BCL2-like 14 (apoptosis facilitator)
BCLAF1 BCL2-associated transcription factor 1
BID BH3 interacting domain death agonist
BIK BCL2-interacting killer (apoptosis-inducing)
BMF Bcl2 modifying factor
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
BNIP1 BCL2/adenovirus E1B 19kDa interacting protein 1
BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIPL BCL2/adenovirus E1B 19kD interacting protein like
BOK BCL2-related ovarian killer
BRAT1 BRCA1-associated ATM activator 1
BUB1B-PAK6 BUB1B-PAK6 readthrough
C19ORF12 chromosome 19 open reading frame 12
CAPN3 calpain 3, (p94)
CASP10 caspase 10, apoptosis-related cysteine peptidase
CASP12 caspase 12 (gene/pseudogene)
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP4 caspase 4, apoptosis-related cysteine peptidase
CASP5 caspase 5, apoptosis-related cysteine peptidase
CASP6 caspase 6, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CD2 CD2 molecule
CDK11A cyclin-dependent kinase 11A
CDK11B cyclin-dependent kinase 11B
CDK5 cyclin-dependent kinase 5
CFLAR CASP8 and FADD-like apoptosis regulator
CGB3 chorionic gonadotropin subunit beta 3
CGB7 chorionic gonadotropin, beta polypeptide 7
CHEK1 checkpoint kinase 1
CIB1 calcium and integrin binding 1 (calmyrin)
CIDEB cell death-inducing DFFA-like effector b
CIDEC cell death-inducing DFFA-like effector c
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
CSRNP1 cysteine-serine-rich nuclear protein 1
CXCR4 chemokine (C-X-C motif) receptor 4
CYFIP2 cytoplasmic FMR1 interacting protein 2
DAB2IP DAB2 interacting protein
DAPK1 death-associated protein kinase 1
DAPK2 death-associated protein kinase 2
DAPK3 death-associated protein kinase 3
DDIT4 DNA-damage-inducible transcript 4
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41
DHDDS dehydrodolichyl diphosphate synthase
DIABLO diablo, IAP-binding mitochondrial protein
DMPK dystrophia myotonica-protein kinase
DNPEP aspartyl aminopeptidase
DPF1 D4, zinc and double PHD fingers family 1
DPF2 D4, zinc and double PHD fingers family 2
DUX4 double homeobox 4
EFNA5 ephrin-A5
ELMO1 engulfment and cell motility 1
EMP1 epithelial membrane protein 1
EMP2 epithelial membrane protein 2
EMP3 epithelial membrane protein 3
EP300 E1A binding protein p300
ERBB3 erb-b2 receptor tyrosine kinase 3
ERCC2 excision repair cross-complementation group 2
ERCC3 excision repair cross-complementation group 3
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
FADD Fas (TNFRSF6)-associated via death domain
FAM162A family with sequence similarity 162, member A
FASLG Fas ligand (TNF superfamily, member 6)
FASN fatty acid synthase
FASTKD2 FAST kinase domains 2
FEM1B fem-1 homolog b (C. elegans)
FOXO1 forkhead box O1
FXR1 fragile X mental retardation, autosomal homolog 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GDF6 growth differentiation factor 6
GLMN glomulin, FKBP associated protein
GLRX2 glutaredoxin 2
GML glycosylphosphatidylinositol anchored molecule like
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX)
GZMM granzyme M (lymphocyte met-ase 1)
HIP1 huntingtin interacting protein 1
HIPK1 homeodomain interacting protein kinase 1
HOOK2 hook microtubule-tethering protein 2
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IAPP islet amyloid polypeptide
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IFI27L1 interferon, alpha-inducible protein 27-like 1
IFI27L2 interferon, alpha-inducible protein 27-like 2
IFI6 interferon, alpha-inducible protein 6
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFNA2 interferon, alpha 2
IFNG interferon, gamma
IFT57 intraflagellar transport 57
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL10 interleukin 10
IL17F interleukin 17F
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL2RA interleukin 2 receptor, alpha
IRF1 interferon regulatory factor 1
IRF3 interferon regulatory factor 3
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
JADE1 jade family PHD finger 1
JAK2 Janus kinase 2
KREMEN1 kringle containing transmembrane protein 1
LALBA lactalbumin, alpha-
LIG4 ligase IV, DNA, ATP-dependent
LMTK1 lemur tail kinase 1
LTA lymphotoxin alpha
MAGEH1 melanoma antigen family H1
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3
MAP3K10 mitogen-activated protein kinase kinase kinase 10
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MCM7 minichromosome maintenance complex component 7
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MELK maternal embryonic leucine zipper kinase
MRPS30 mitochondrial ribosomal protein S30
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MX1 MX dynamin-like GTPase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYD88 myeloid differentiation primary response 88
NAE1 NEDD8 activating enzyme E1 subunit 1
NCKAP1 NCK-associated protein 1
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
NGF nerve growth factor (beta polypeptide)
NGFR nerve growth factor receptor
NLRP1 NLR family, pyrin domain containing 1
NLRP3 NLR family, pyrin domain containing 3
NME3 NME/NM23 nucleoside diphosphate kinase 3
NOTCH2 notch 2
NOX5 NADPH oxidase, EF-hand calcium binding domain 5
NSG1 neuron specific gene family member 1
NUDT2 nudix (nucleoside diphosphate linked moiety X)-type motif 2
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PAEP progestagen-associated endometrial protein
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PARP1 poly (ADP-ribose) polymerase 1
PAWR PRKC, apoptosis, WT1, regulator
PAX3 paired box 3
PDCD1 programmed cell death 1
PDCD2L programmed cell death 2-like
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIDD1 p53-induced death domain protein 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLAGL1 pleiomorphic adenoma gene-like 1
PLK3 polo-like kinase 3
PLSCR1 phospholipid scramblase 1
PLSCR3 phospholipid scramblase 3
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PML promyelocytic leukemia
PPARD peroxisome proliferator-activated receptor delta
PPIA peptidylprolyl isomerase A (cyclophilin A)
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRKCD protein kinase C, delta
PRKCE protein kinase C, epsilon
PRUNE2 prune homolog 2 (Drosophila)
PTK2B protein tyrosine kinase 2 beta
PXMP2 peroxisomal membrane protein 2, 22kDa
PYCARD PYD and CARD domain containing
RELT RELT tumor necrosis factor receptor
RFK riboflavin kinase
RHOB ras homolog family member B
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RIPK2 receptor-interacting serine-threonine kinase 2
RNASE3 ribonuclease, RNase A family, 3
RNF152 ring finger protein 152
RRAGC Ras-related GTP binding C
RTN4 reticulon 4
SCN2A sodium channel, voltage gated, type II alpha subunit
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SEPTIN4 septin 4
SFRP5 secreted frizzled-related protein 5
SIAH1 siah E3 ubiquitin protein ligase 1
STK11 serine/threonine kinase 11
STK24 serine/threonine kinase 24
STK4 serine/threonine kinase 4
TAOK2 TAO kinase 2
TBX1 T-box 1
TCHP trichoplein, keratin filament binding
TGFB1 transforming growth factor, beta 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein
TLR2 toll-like receptor 2
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial)
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF19 tumor necrosis factor receptor superfamily, member 19
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14
TP53AIP1 tumor protein p53 regulated apoptosis inducing protein 1
TP63 tumor protein p63
TRADD TNFRSF1A-associated via death domain
TRAF7 TNF receptor-associated factor 7, E3 ubiquitin protein ligase
TRAIP TRAF interacting protein
TRPC5 transient receptor potential cation channel, subfamily C, member 5
TSC2 tuberous sclerosis 2
VDAC1 voltage-dependent anion channel 1
YARS1 tyrosyl-tRNA synthetase 1
ZBTB16 zinc finger and BTB domain containing 16
ZNF385A zinc finger protein 385A
ZNF395 zinc finger protein 395
ZNF443 zinc finger protein 443