app Gene Set

Dataset Phosphosite Textmining Biological Term Annotations
Category structural or functional annotations
Type biological term
Description amyloid beta (A4) precursor protein|This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014] (NCBI Entrez Gene Database, 351)
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Genes

31 proteins co-occuring with the biological term app in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

Symbol Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
APLP1 amyloid beta (A4) precursor-like protein 1
APLP2 amyloid beta (A4) precursor-like protein 2
APP amyloid beta (A4) precursor protein
BACE1 beta-site APP-cleaving enzyme 1
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CPEB1 cytoplasmic polyadenylation element binding protein 1
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
DPYSL2 dihydropyrimidinase-like 2
GRIA2 glutamate receptor, ionotropic, AMPA 2
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
H2AFX H2A histone family, member X
KAT5 K(lysine) acetyltransferase 5
LRP1 low density lipoprotein receptor-related protein 1
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MAPK9 mitogen-activated protein kinase 9
MAPT microtubule-associated protein tau
PSEN1 presenilin 1
PSEN2 presenilin 2
SIKE1 suppressor of IKBKE 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAR steroidogenic acute regulatory protein
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2