apramycin-4959 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the apramycin-4959 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ACTC1 actin, alpha, cardiac muscle 1
ADARB1 adenosine deaminase, RNA-specific, B1
AK1 adenylate kinase 1
ANP32A-IT1 ANP32A intronic transcript 1
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ASPH aspartate beta-hydroxylase
ATAT1 alpha tubulin acetyltransferase 1
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BEX1 brain expressed, X-linked 1
BGLAP bone gamma-carboxyglutamate (gla) protein
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C7ORF69 chromosome 7 open reading frame 69
CABIN1 calcineurin binding protein 1
CAMK4 calcium/calmodulin-dependent protein kinase IV
CCL21 chemokine (C-C motif) ligand 21
CD82 CD82 molecule
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CHML choroideremia-like (Rab escort protein 2)
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CLCN7 chloride channel, voltage-sensitive 7
CNTN1 contactin 1
COL10A1 collagen, type X, alpha 1
DAAM2 dishevelled associated activator of morphogenesis 2
DGCR2 DiGeorge syndrome critical region gene 2
DUSP9 dual specificity phosphatase 9
EFR3B EFR3 homolog B (S. cerevisiae)
EMP3 epithelial membrane protein 3
FLJ11292
FMO5 flavin containing monooxygenase 5
FRMPD1 FERM and PDZ domain containing 1
FYB FYN binding protein
GBP1 guanylate binding protein 1, interferon-inducible
GLP1R glucagon-like peptide 1 receptor
HGD homogentisate 1,2-dioxygenase
HIST1H4D histone cluster 1, H4d
HIST1H4E histone cluster 1, H4e
HMOX1 heme oxygenase 1
HOXB5 homeobox B5
IDS iduronate 2-sulfatase
IDUA iduronidase, alpha-L-
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
IL6ST interleukin 6 signal transducer
INPP5B inositol polyphosphate-5-phosphatase, 75kDa
ISL1 ISL LIM homeobox 1
JAK3 Janus kinase 3
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KRT85 keratin 85, type II
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LMF2 lipase maturation factor 2
MCOLN1 mucolipin 1
MEG3 maternally expressed 3 (non-protein coding)
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MYL4 myosin, light chain 4, alkali; atrial, embryonic
MYLPF myosin light chain, phosphorylatable, fast skeletal muscle
NEUROD1 neuronal differentiation 1
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NOP16 NOP16 nucleolar protein
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
ORAI2 ORAI calcium release-activated calcium modulator 2
PCSK6 proprotein convertase subtilisin/kexin type 6
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLEKHO2 pleckstrin homology domain containing, family O member 2
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D
PRF1 perforin 1 (pore forming protein)
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PTX3 pentraxin 3, long
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RAD23B RAD23 homolog B (S. cerevisiae)
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RBM5 RNA binding motif protein 5
RHBDL1 rhomboid, veinlet-like 1 (Drosophila)
RUNX1 runt-related transcription factor 1
SHOX2 short stature homeobox 2
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SNTA1 syntrophin, alpha 1
SRSF7 serine/arginine-rich splicing factor 7
STEAP4 STEAP family member 4
STON1 stonin 1
TBC1D2 TBC1 domain family, member 2
TBKBP1 TBK1 binding protein 1
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TNK2 tyrosine kinase, non-receptor, 2
UHRF1BP1L UHRF1 binding protein 1-like
UPK2 uroplakin 2
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
VIPR1 vasoactive intestinal peptide receptor 1
WSB1 WD repeat and SOCS box containing 1
ZNF446 zinc finger protein 446
ZNF484 zinc finger protein 484

decreased expression

Symbol Name
ABHD17B abhydrolase domain containing 17B
AES amino-terminal enhancer of split
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ATXN2 ataxin 2
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
BAHCC1 BAH domain and coiled-coil containing 1
BAK1 BCL2-antagonist/killer 1
BCAS1 breast carcinoma amplified sequence 1
BRPF1 bromodomain and PHD finger containing, 1
C5ORF45 chromosome 5 open reading frame 45
CBX8 chromobox homolog 8
CCDC186 coiled-coil domain containing 186
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CERK ceramide kinase
COMMD9 COMM domain containing 9
CORT cortistatin
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24
DTX4 deltex 4, E3 ubiquitin ligase
EFNA3 ephrin-A3
ENO2 enolase 2 (gamma, neuronal)
FAM63A family with sequence similarity 63, member A
FAM86C1 family with sequence similarity 86, member C1
FBXL15 F-box and leucine-rich repeat protein 15
FBXL6 F-box and leucine-rich repeat protein 6
FLRT3 fibronectin leucine rich transmembrane protein 3
GSTM2 glutathione S-transferase mu 2 (muscle)
HIST1H1E histone cluster 1, H1e
HIST1H2BO histone cluster 1, H2bo
HOXC10 homeobox C10
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
IDI2-AS1 IDI2 antisense RNA 1
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IPO8 importin 8
IRAK4 interleukin-1 receptor-associated kinase 4
ISG15 ISG15 ubiquitin-like modifier
ITGA10 integrin, alpha 10
JMJD4 jumonji domain containing 4
LIN7B lin-7 homolog B (C. elegans)
LMNB1 lamin B1
LOC730101 uncharacterized LOC730101
LRP5L low density lipoprotein receptor-related protein 5-like
MAMLD1 mastermind-like domain containing 1
METTL16 methyltransferase like 16
MICALL2 MICAL-like 2
MUM1 melanoma associated antigen (mutated) 1
MYL5 myosin, light chain 5, regulatory
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
NPY1R neuropeptide Y receptor Y1
NUAK1 NUAK family, SNF1-like kinase, 1
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PLA2G3 phospholipase A2, group III
PLCD1 phospholipase C, delta 1
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PODXL podocalyxin-like
PTPN9 protein tyrosine phosphatase, non-receptor type 9
QPCT glutaminyl-peptide cyclotransferase
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RPGR retinitis pigmentosa GTPase regulator
RPGRIP1L RPGRIP1-like
RPUSD2 RNA pseudouridylate synthase domain containing 2
RUNDC3B RUN domain containing 3B
S100A4 S100 calcium binding protein A4
SETD1A SET domain containing 1A
SETD8 SET domain containing (lysine methyltransferase) 8
SLC41A3 solute carrier family 41, member 3
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SLMO1 slowmo homolog 1 (Drosophila)
STRN striatin, calmodulin binding protein
STX1A syntaxin 1A (brain)
SUSD4 sushi domain containing 4
SYCP2 synaptonemal complex protein 2
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TUBA3C tubulin, alpha 3c
ULBP2 UL16 binding protein 2
UNC119 unc-119 homolog (C. elegans)
UPK3B uroplakin 3B
VAV1 vav 1 guanine nucleotide exchange factor
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
WFDC2 WAP four-disulfide core domain 2
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZBTB48 zinc finger and BTB domain containing 48
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZFP69B ZFP69 zinc finger protein B
ZMAT5 zinc finger, matrin-type 5
ZNF219 zinc finger protein 219
ZNF250 zinc finger protein 250
ZNF329 zinc finger protein 329
ZNF639 zinc finger protein 639
ZNF669 zinc finger protein 669
ZNF813 zinc finger protein 813
ZNRD1-AS1 ZNRD1 antisense RNA 1