arrested b cell differentiation Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description inability to produce mature B cells, and accumulation of B cell precursors (Mammalian Phenotype Ontology, MP_0001802)
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42 gene mutations causing the arrested b cell differentiation phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ATP11C ATPase, class VI, type 11C
BLNK B-cell linker
CD22 CD22 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD79B CD79b molecule, immunoglobulin-associated beta
DCLRE1C DNA cross-link repair 1C
EBF1 early B-cell factor 1
FLT3 fms-related tyrosine kinase 3
FNIP1 folliculin interacting protein 1
FOXP1 forkhead box P1
GON4L gon-4-like (C. elegans)
IGHM immunoglobulin heavy constant mu
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL2RG interleukin 2 receptor, gamma
IL7 interleukin 7
IL7R interleukin 7 receptor
IRF4 interferon regulatory factor 4
JAK1 Janus kinase 1
JAK3 Janus kinase 3
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LIG4 ligase IV, DNA, ATP-dependent
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MYB v-myb avian myeloblastosis viral oncogene homolog
PAX5 paired box 5
PIK3AP1 phosphoinositide-3-kinase adaptor protein 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
POU2AF1 POU class 2 associating factor 1
POU2F2 POU class 2 homeobox 2
PRKDC protein kinase, DNA-activated, catalytic polypeptide
RAG1 recombination activating gene 1
RAG2 recombination activating gene 2
SPI1 Spi-1 proto-oncogene
SPPL2A signal peptide peptidase like 2A
SYK spleen tyrosine kinase
TCF3 transcription factor 3
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
VPREB1 pre-B lymphocyte 1
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6