articaine-6517 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the articaine-6517 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCD4 ATP-binding cassette, sub-family D (ALD), member 4
ADCK4 aarF domain containing kinase 4
ADH6 alcohol dehydrogenase 6 (class V)
AKAP7 A kinase (PRKA) anchor protein 7
ALOX12 arachidonate 12-lipoxygenase
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide
BMP8A bone morphogenetic protein 8a
CACYBP calcyclin binding protein
CALD1 caldesmon 1
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CBX8 chromobox homolog 8
CCZ1 CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae)
CD52 CD52 molecule
CIB2 calcium and integrin binding family member 2
CNOT4 CCR4-NOT transcription complex, subunit 4
CYTH4 cytohesin 4
DMC1 DNA meiotic recombinase 1
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
DPP4 dipeptidyl-peptidase 4
EDNRA endothelin receptor type A
EFNA3 ephrin-A3
EFNB3 ephrin-B3
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3
EPAS1 endothelial PAS domain protein 1
EPB41L4A erythrocyte membrane protein band 4.1 like 4A
ERAP1 endoplasmic reticulum aminopeptidase 1
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
FAM182B family with sequence similarity 182, member B
FFAR2 free fatty acid receptor 2
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
GAS7 growth arrest-specific 7
GPER1 G protein-coupled estrogen receptor 1
GSTCD glutathione S-transferase, C-terminal domain containing
GSTM5 glutathione S-transferase mu 5
GYPB glycophorin B (MNS blood group)
HDAC11 histone deacetylase 11
HEG1 heart development protein with EGF-like domains 1
HP1BP3 heterochromatin protein 1, binding protein 3
IAPP islet amyloid polypeptide
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IL36G interleukin 36, gamma
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
ISG20 interferon stimulated exonuclease gene 20kDa
ITGB4 integrin, beta 4
ITK IL2-inducible T-cell kinase
JAM3 junctional adhesion molecule 3
KCTD17 potassium channel tetramerization domain containing 17
KIAA1644 KIAA1644
KIF25 kinesin family member 25
LAMB4 laminin, beta 4
LIMD1 LIM domains containing 1
LMF2 lipase maturation factor 2
MBD3 methyl-CpG binding domain protein 3
METTL7A methyltransferase like 7A
MSI1 musashi RNA-binding protein 1
MST1 macrophage stimulating 1
MTA1 metastasis associated 1
MTRF1L mitochondrial translational release factor 1-like
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MUSK muscle, skeletal, receptor tyrosine kinase
MX2 MX dynamin-like GTPase 2
NEUROD1 neuronal differentiation 1
NIPAL3 NIPA-like domain containing 3
NREP neuronal regeneration related protein
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
ORM1 orosomucoid 1
OVGP1 oviductal glycoprotein 1, 120kDa
OVOL1 ovo-like zinc finger 1
PCSK6 proprotein convertase subtilisin/kexin type 6
PDLIM7 PDZ and LIM domain 7 (enigma)
PEX16 peroxisomal biogenesis factor 16
PKD2L2 polycystic kidney disease 2-like 2
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PON1 paraoxonase 1
POU2F3 POU class 2 homeobox 3
RARA retinoic acid receptor, alpha
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RNF43 ring finger protein 43
RTN2 reticulon 2
SATB2 SATB homeobox 2
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5
SNAP25 synaptosomal-associated protein, 25kDa
SYNJ1 synaptojanin 1
TAOK2 TAO kinase 2
TAS2R10 taste receptor, type 2, member 10
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMOD1 tropomodulin 1
TOX4 TOX high mobility group box family member 4
TRA T cell receptor alpha locus
TRIM2 tripartite motif containing 2
TRPM2 transient receptor potential cation channel, subfamily M, member 2
VIPR2 vasoactive intestinal peptide receptor 2
ZBTB48 zinc finger and BTB domain containing 48
ZEB1 zinc finger E-box binding homeobox 1
ZNF134 zinc finger protein 134
ZNF318 zinc finger protein 318

decreased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
ANP32A-IT1 ANP32A intronic transcript 1
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ATP10D ATPase, class V, type 10D
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BCL9 B-cell CLL/lymphoma 9
BMP15 bone morphogenetic protein 15
C11ORF30 chromosome 11 open reading frame 30
C1ORF105 chromosome 1 open reading frame 105
C1QTNF3 C1q and tumor necrosis factor related protein 3
C2ORF27A chromosome 2 open reading frame 27A
C8ORF60 chromosome 8 open reading frame 60
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CCDC69 coiled-coil domain containing 69
CCNO cyclin O
CD83 CD83 molecule
CDON cell adhesion associated, oncogene regulated
CENPQ centromere protein Q
CEP85 centrosomal protein 85kDa
CGA glycoprotein hormones, alpha polypeptide
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
DYSF dysferlin
EDAR ectodysplasin A receptor
ELOVL4 ELOVL fatty acid elongase 4
F3 coagulation factor III (thromboplastin, tissue factor)
FAM110B family with sequence similarity 110, member B
FAM131A family with sequence similarity 131, member A
FAM155A family with sequence similarity 155, member A
FAM169A family with sequence similarity 169, member A
FBXO31 F-box protein 31
FBXO46 F-box protein 46
FOXN2 forkhead box N2
FRK fyn-related Src family tyrosine kinase
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
HAMP hepcidin antimicrobial peptide
HHLA3 HERV-H LTR-associating 3
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
INPP5J inositol polyphosphate-5-phosphatase J
JMJD4 jumonji domain containing 4
KIAA0754 KIAA0754
KLHL25 kelch-like family member 25
KRT20 keratin 20, type I
LMO2 LIM domain only 2 (rhombotin-like 1)
LOC730101 uncharacterized LOC730101
LTBP2 latent transforming growth factor beta binding protein 2
MAN2C1 mannosidase, alpha, class 2C, member 1
MICALL2 MICAL-like 2
MTCL1 microtubule crosslinking factor 1
MTERF4 mitochondrial transcription termination factor 4
MTRF1 mitochondrial translational release factor 1
MXD3 MAX dimerization protein 3
NLRX1 NLR family member X1
NR1H2 nuclear receptor subfamily 1, group H, member 2
NUS1P3 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) pseudogene 3
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PLD2 phospholipase D2
PLD3 phospholipase D family, member 3
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
PRAF2 PRA1 domain family, member 2
RANGRF RAN guanine nucleotide release factor
RHBG Rh family, B glycoprotein (gene/pseudogene)
RNF126P1 ring finger protein 126 pseudogene 1
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC26A6 solute carrier family 26 (anion exchanger), member 6
SPAG4 sperm associated antigen 4
SPINK5 serine peptidase inhibitor, Kazal type 5
STAG3L1 stromal antigen 3-like 1 (pseudogene)
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STEAP1 six transmembrane epithelial antigen of the prostate 1
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
SYBU syntabulin (syntaxin-interacting)
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TCTN1 tectonic family member 1
TFF2 trefoil factor 2
TMC5 transmembrane channel-like 5
TSPAN2 tetraspanin 2
TTLL1 tubulin tyrosine ligase-like family member 1
UBXN6 UBX domain protein 6
UNC119 unc-119 homolog (C. elegans)
UPK3B uroplakin 3B
USP19 ubiquitin specific peptidase 19
WNT10B wingless-type MMTV integration site family, member 10B
ZC3H3 zinc finger CCCH-type containing 3
ZMAT5 zinc finger, matrin-type 5
ZNF212 zinc finger protein 212
ZNF442 zinc finger protein 442
ZNF492 zinc finger protein 492
ZNF573 zinc finger protein 573
ZNF816 zinc finger protein 816