ascorbic acid-5407 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the ascorbic acid-5407 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A1CF APOBEC1 complementation factor
ACVR1B activin A receptor, type IB
AKT2 v-akt murine thymoma viral oncogene homolog 2
ALDOB aldolase B, fructose-bisphosphate
ANXA2P3 annexin A2 pseudogene 3
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
C11ORF63 chromosome 11 open reading frame 63
C14ORF79 chromosome 14 open reading frame 79
C17ORF59 chromosome 17 open reading frame 59
C1ORF105 chromosome 1 open reading frame 105
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CASP1 caspase 1, apoptosis-related cysteine peptidase
CLCN4 chloride channel, voltage-sensitive 4
CLCN7 chloride channel, voltage-sensitive 7
CLMN calmin (calponin-like, transmembrane)
CNOT4 CCR4-NOT transcription complex, subunit 4
COMT catechol-O-methyltransferase
CORO2B coronin, actin binding protein, 2B
CRISP2 cysteine-rich secretory protein 2
CSF1 colony stimulating factor 1 (macrophage)
CYHR1 cysteine/histidine-rich 1
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DOCK6 dedicator of cytokinesis 6
DPEP2 dipeptidase 2
EFNB3 ephrin-B3
FABP3 fatty acid binding protein 3, muscle and heart
FGL1 fibrinogen-like 1
FMO5 flavin containing monooxygenase 5
FSCN1 fascin actin-bundling protein 1
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1
GJA4 gap junction protein, alpha 4, 37kDa
GPR15 G protein-coupled receptor 15
GSPT2 G1 to S phase transition 2
GSTP1 glutathione S-transferase pi 1
HIST1H2BM histone cluster 1, H2bm
ICOSLG inducible T-cell co-stimulator ligand
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGF1R insulin-like growth factor 1 receptor
IPW imprinted in Prader-Willi syndrome (non-protein coding)
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KDM4C lysine (K)-specific demethylase 4C
KIAA1107 KIAA1107
KMT2A lysine (K)-specific methyltransferase 2A
LAMA3 laminin, alpha 3
LGALS8 lectin, galactoside-binding, soluble, 8
LY6G6C lymphocyte antigen 6 complex, locus G6C
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA1 melanoma antigen family A1
MAGEC1 melanoma antigen family C1
MAOA monoamine oxidase A
MAP4 microtubule-associated protein 4
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MBD3 methyl-CpG binding domain protein 3
MYO1B myosin IB
NOX5 NADPH oxidase, EF-hand calcium binding domain 5
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
PCDHA3 protocadherin alpha 3
PCDHB6 protocadherin beta 6
PLAU plasminogen activator, urokinase
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLCD1 phospholipase C, delta 1
PON1 paraoxonase 1
POU3F2 POU class 3 homeobox 2
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D
PPP1R37 protein phosphatase 1, regulatory subunit 37
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta
PPP5C protein phosphatase 5, catalytic subunit
PTAFR platelet-activating factor receptor
PVT1 Pvt1 oncogene (non-protein coding)
RAD52 RAD52 homolog (S. cerevisiae)
RAG1 recombination activating gene 1
RBBP9 retinoblastoma binding protein 9
RBP4 retinol binding protein 4, plasma
RHEB Ras homolog enriched in brain
RIMS3 regulating synaptic membrane exocytosis 3
S100A7 S100 calcium binding protein A7
SFTPB surfactant protein B
SH3BP2 SH3-domain binding protein 2
SIK3 SIK family kinase 3
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1
SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2
SLC39A2 solute carrier family 39 (zinc transporter), member 2
SLMO1 slowmo homolog 1 (Drosophila)
SNCA synuclein, alpha (non A4 component of amyloid precursor)
STEAP4 STEAP family member 4
TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa
TBC1D2B TBC1 domain family, member 2B
TSNAXIP1 translin-associated factor X interacting protein 1
VPS9D1 VPS9 domain containing 1
VWA5A von Willebrand factor A domain containing 5A
WDR62 WD repeat domain 62
ZEB1 zinc finger E-box binding homeobox 1
ZFAND5 zinc finger, AN1-type domain 5

decreased expression

Symbol Name
ACSL4 acyl-CoA synthetase long-chain family member 4
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
ALPK1 alpha-kinase 1
ANP32A-IT1 ANP32A intronic transcript 1
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma
ARMC4 armadillo repeat containing 4
BCAS1 breast carcinoma amplified sequence 1
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BLNK B-cell linker
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2
BTBD2 BTB (POZ) domain containing 2
BTF3P12 basic transcription factor 3 pseudogene 12
C11ORF30 chromosome 11 open reading frame 30
C16ORF45 chromosome 16 open reading frame 45
C22ORF29 chromosome 22 open reading frame 29
C4ORF29 chromosome 4 open reading frame 29
CCDC85C coiled-coil domain containing 85C
CCDC88C coiled-coil domain containing 88C
CD8A CD8a molecule
CES3 carboxylesterase 3
CLIC2 chloride intracellular channel 2
CNGB3 cyclic nucleotide gated channel beta 3
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae)
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DGAT1 diacylglycerol O-acyltransferase 1
DSCAM Down syndrome cell adhesion molecule
DUSP13 dual specificity phosphatase 13
DZANK1 double zinc ribbon and ankyrin repeat domains 1
EGFL7 EGF-like-domain, multiple 7
EPHX2 epoxide hydrolase 2, cytoplasmic
ERN2 endoplasmic reticulum to nucleus signaling 2
F8 coagulation factor VIII, procoagulant component
FAM212B family with sequence similarity 212, member B
FILIP1L filamin A interacting protein 1-like
FOSL1 FOS-like antigen 1
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GNG7 guanine nucleotide binding protein (G protein), gamma 7
HIST1H2AL histone cluster 1, H2al
HOXC5 homeobox C5
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
HSPA1L heat shock 70kDa protein 1-like
IFI27 interferon, alpha-inducible protein 27
IGFBP6 insulin-like growth factor binding protein 6
INO80D INO80 complex subunit D
IPO8 importin 8
IRAK4 interleukin-1 receptor-associated kinase 4
IRF6 interferon regulatory factor 6
KDM5C lysine (K)-specific demethylase 5C
KLK5 kallikrein-related peptidase 5
KPNA4 karyopherin alpha 4 (importin alpha 3)
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LIN7A lin-7 homolog A (C. elegans)
LOC390998 ribosomal protein L10 pseudogene
LOC730101 uncharacterized LOC730101
LRP2 low density lipoprotein receptor-related protein 2
MBNL3 muscleblind-like splicing regulator 3
MTERF4 mitochondrial transcription termination factor 4
MUL1 mitochondrial E3 ubiquitin protein ligase 1
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
NPM3 nucleophosmin/nucleoplasmin 3
NT5DC3 5'-nucleotidase domain containing 3
OGFRL1 opioid growth factor receptor-like 1
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
PADI1 peptidyl arginine deiminase, type I
PAIP2B poly(A) binding protein interacting protein 2B
PCDHGB5 protocadherin gamma subfamily B, 5
PDE12 phosphodiesterase 12
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PGR progesterone receptor
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
POM121 POM121 transmembrane nucleoporin
PTDSS2 phosphatidylserine synthase 2
RNF126P1 ring finger protein 126 pseudogene 1
SAYSD1 SAYSVFN motif domain containing 1
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SLIT2 slit homolog 2 (Drosophila)
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
STARD13 StAR-related lipid transfer (START) domain containing 13
TBC1D19 TBC1 domain family, member 19
TMEM254 transmembrane protein 254
TOM1 target of myb1 (chicken)
TRPC5 transient receptor potential cation channel, subfamily C, member 5
TTLL1 tubulin tyrosine ligase-like family member 1
TUBA3C tubulin, alpha 3c
USP27X ubiquitin specific peptidase 27, X-linked
XAB2 XPA binding protein 2
ZBTB48 zinc finger and BTB domain containing 48
ZDHHC14 zinc finger, DHHC-type containing 14
ZNF136 zinc finger protein 136
ZNF250 zinc finger protein 250
ZNF280D zinc finger protein 280D
ZNF282 zinc finger protein 282
ZNF442 zinc finger protein 442
ZNF574 zinc finger protein 574
ZNF668 zinc finger protein 668
ZNF669 zinc finger protein 669