ascorbic acid-6306 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the ascorbic acid-6306 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTN2 actinin, alpha 2
AFF4 AF4/FMR2 family, member 4
ALG12 ALG12, alpha-1,6-mannosyltransferase
ALK anaplastic lymphoma receptor tyrosine kinase
AP1M2 adaptor-related protein complex 1, mu 2 subunit
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ATP9A ATPase, class II, type 9A
BCAP29 B-cell receptor-associated protein 29
C1ORF21 chromosome 1 open reading frame 21
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CALD1 caldesmon 1
CBS cystathionine-beta-synthase
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CD300A CD300a molecule
CDH4 cadherin 4, type 1, R-cadherin (retinal)
CDV3 CDV3 homolog (mouse)
CLEC4E C-type lectin domain family 4, member E
CNR2 cannabinoid receptor 2 (macrophage)
COPE coatomer protein complex, subunit epsilon
CPNE7 copine VII
CTNS cystinosin, lysosomal cystine transporter
DFNB31 deafness, autosomal recessive 31
DLGAP1 discs, large (Drosophila) homolog-associated protein 1
DMTN dematin actin binding protein
DNAH7 dynein, axonemal, heavy chain 7
DTX2 deltex 2, E3 ubiquitin ligase
DTX2P1-UPK3BP1-PMS2P11 DTX2P1-UPK3BP1-PMS2P11 readthrough transcribed pseudogene
EFNA3 ephrin-A3
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
FGFR1 fibroblast growth factor receptor 1
GOSR2 golgi SNAP receptor complex member 2
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
HIPK3 homeodomain interacting protein kinase 3
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HNF1B HNF1 homeobox B
HOMER3 homer scaffolding protein 3
HOXB2 homeobox B2
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
IL11 interleukin 11
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
IQCG IQ motif containing G
IQCK IQ motif containing K
KANK1 KN motif and ankyrin repeat domains 1
KAZALD1 Kazal-type serine peptidase inhibitor domain 1
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KLF4 Kruppel-like factor 4 (gut)
L3MBTL1 l(3)mbt-like 1 (Drosophila)
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LPAR6 lysophosphatidic acid receptor 6
LPCAT4 lysophosphatidylcholine acyltransferase 4
MAK male germ cell-associated kinase
MBTPS2 membrane-bound transcription factor peptidase, site 2
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
MRC2 mannose receptor, C type 2
MXD3 MAX dimerization protein 3
NF2 neurofibromin 2 (merlin)
NME5 NME/NM23 family member 5
NOP16 NOP16 nucleolar protein
NRG1 neuregulin 1
NXPH3 neurexophilin 3
OSMR oncostatin M receptor
PDZK1 PDZ domain containing 1
PHLDB1 pleckstrin homology-like domain, family B, member 1
POFUT1 protein O-fucosyltransferase 1
PTK7 protein tyrosine kinase 7 (inactive)
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
RUNX1 runt-related transcription factor 1
SAFB2 scaffold attachment factor B2
SH2D3A SH2 domain containing 3A
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC46A3 solute carrier family 46, member 3
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SOX15 SRY (sex determining region Y)-box 15
SRSF1 serine/arginine-rich splicing factor 1
ST6GALNAC4 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
STRN3 striatin, calmodulin binding protein 3
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
TADA3 transcriptional adaptor 3
TESPA1 thymocyte expressed, positive selection associated 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TGFB2 transforming growth factor, beta 2
THRAP3 thyroid hormone receptor associated protein 3
THRB thyroid hormone receptor, beta
TK2 thymidine kinase 2, mitochondrial
TLR4 toll-like receptor 4
TM4SF5 transmembrane 4 L six family member 5
TMEM53 transmembrane protein 53
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
UBE3B ubiquitin protein ligase E3B
WDR76 WD repeat domain 76
WNT16 wingless-type MMTV integration site family, member 16
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF276 zinc finger protein 276
ZNF287 zinc finger protein 287

decreased expression

Symbol Name
ABHD8 abhydrolase domain containing 8
ACAD10 acyl-CoA dehydrogenase family, member 10
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
ANKZF1 ankyrin repeat and zinc finger domain containing 1
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ATF7IP2 activating transcription factor 7 interacting protein 2
ATP7A ATPase, Cu++ transporting, alpha polypeptide
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BCCIP BRCA2 and CDKN1A interacting protein
BIRC3 baculoviral IAP repeat containing 3
BRMS1 breast cancer metastasis suppressor 1
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
BTF3P12 basic transcription factor 3 pseudogene 12
C1QTNF1 C1q and tumor necrosis factor related protein 1
C1RL complement component 1, r subcomponent-like
CBR4 carbonyl reductase 4
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CCDC85C coiled-coil domain containing 85C
CCDC88C coiled-coil domain containing 88C
CCNT1 cyclin T1
CENPO centromere protein O
CGREF1 cell growth regulator with EF-hand domain 1
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3
CHMP6 charged multivesicular body protein 6
CISH cytokine inducible SH2-containing protein
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
CPA4 carboxypeptidase A4
DDIT3 DNA-damage-inducible transcript 3
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DHX38 DEAH (Asp-Glu-Ala-His) box polypeptide 38
DNMBP dynamin binding protein
EHD3 EH-domain containing 3
FAM50B family with sequence similarity 50, member B
FBXO46 F-box protein 46
FSD1 fibronectin type III and SPRY domain containing 1
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GAREM GRB2 associated, regulator of MAPK1
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GRWD1 glutamate-rich WD repeat containing 1
GTPBP2 GTP binding protein 2
HIST1H1D histone cluster 1, H1d
HIST1H2AM histone cluster 1, H2am
HIST1H3G histone cluster 1, H3g
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
IDI2-AS1 IDI2 antisense RNA 1
INPPL1 inositol polyphosphate phosphatase-like 1
KIAA0232 KIAA0232
LOC100286895 cell division cycle 27 homolog pseudogene
LRFN3 leucine rich repeat and fibronectin type III domain containing 3
LRRC20 leucine rich repeat containing 20
LRRC49 leucine rich repeat containing 49
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MAST3 microtubule associated serine/threonine kinase 3
MCOLN1 mucolipin 1
MFSD12 major facilitator superfamily domain containing 12
MNX1 motor neuron and pancreas homeobox 1
MRPL28 mitochondrial ribosomal protein L28
MUC3B mucin 3B, cell surface associated
NCSTN nicastrin
NHEJ1 nonhomologous end-joining factor 1
NLRX1 NLR family member X1
NR2C2 nuclear receptor subfamily 2, group C, member 2
NRTN neurturin
PDGFRL platelet-derived growth factor receptor-like
PHKG2 phosphorylase kinase, gamma 2 (testis)
POM121 POM121 transmembrane nucleoporin
PRPH peripherin
RAB33B RAB33B, member RAS oncogene family
RGS17 regulator of G-protein signaling 17
RNF121 ring finger protein 121
SCD5 stearoyl-CoA desaturase 5
SCN1B sodium channel, voltage gated, type I beta subunit
SCRN3 secernin 3
SERTAD3 SERTA domain containing 3
SIPA1 signal-induced proliferation-associated 1
SLC12A9 solute carrier family 12, member 9
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SPATA2L spermatogenesis associated 2-like
STBD1 starch binding domain 1
TOLLIP toll interacting protein
TOR4A torsin family 4, member A
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TRAIP TRAF interacting protein
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TTC26 tetratricopeptide repeat domain 26
UNC119 unc-119 homolog (C. elegans)
URM1 ubiquitin related modifier 1
XPA xeroderma pigmentosum, complementation group A
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
ZNF197 zinc finger protein 197
ZNF324 zinc finger protein 324
ZNF358 zinc finger protein 358
ZNF629 zinc finger protein 629
ZNF767P zinc finger family member 767, pseudogene
ZNF816 zinc finger protein 816