asthenozoospermia Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description loss or reduction of the mobility of the spermatozoa, frequently associated with infertility (Mammalian Phenotype Ontology, MP_0002675)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0002675
Similar Terms
Downloads & Tools

Genes

139 gene mutations causing the asthenozoospermia phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADAD1 adenosine deaminase domain containing 1 (testis-specific)
ADAM1A ADAM metallopeptidase domain 1A (pseudogene)
ADAM2 ADAM metallopeptidase domain 2
ADCY10 adenylate cyclase 10 (soluble)
ADCY3 adenylate cyclase 3
ADGRG2 adhesion G protein-coupled receptor G2
AGFG1 ArfGAP with FG repeats 1
AGTPBP1 ATP/GTP binding protein 1
AKAP4 A kinase (PRKA) anchor protein 4
APOB apolipoprotein B
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAT1 alpha tubulin acetyltransferase 1
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BRWD1 bromodomain and WD repeat domain containing 1
CADM1 cell adhesion molecule 1
CATSPER1 cation channel, sperm associated 1
CATSPER2 cation channel, sperm associated 2
CATSPER3 cation channel, sperm associated 3
CATSPER4 cation channel, sperm associated 4
CATSPERD catsper channel auxiliary subunit delta
CD59 CD59 molecule, complement regulatory protein
CDK16 cyclin-dependent kinase 16
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHD5 chromodomain helicase DNA binding protein 5
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal)
CNOT7 CCR4-NOT transcription complex, subunit 7
CPLX1 complexin 1
CST3 cystatin C
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant
CUL4A cullin 4A
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
DNAH1 dynein, axonemal, heavy chain 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DPCD deleted in primary ciliary dyskinesia homolog (mouse)
ELK1 ELK1, member of ETS oncogene family
ENO4 enolase family member 4
EPHB6 EPH receptor B6
ESR1 estrogen receptor 1
ETV5 ets variant 5
EXO1 exonuclease 1
FHL5 four and a half LIM domains 5
FKBP4 FK506 binding protein 4, 59kDa
FOXN1 forkhead box N1
FSHB follicle stimulating hormone, beta polypeptide
FSHR follicle stimulating hormone receptor
GALNTL5 polypeptide N-acetylgalactosaminyltransferase-like 5
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
GMCL1 germ cell-less, spermatogenesis associated 1
GOLGA3 golgin A3
GOPC golgi-associated PDZ and coiled-coil motif containing
H1FNT H1 histone family, member N, testis-specific
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4
HMGB2 high mobility group box 2
HSPA4 heat shock 70kDa protein 4
HSPA4L heat shock 70kDa protein 4-like
ING2 inhibitor of growth family, member 2
INPP5B inositol polyphosphate-5-phosphatase, 75kDa
INSL5 insulin-like 5
INSL6 insulin-like 6
JUND jun D proto-oncogene
KATNB1 katanin p80 (WD repeat containing) subunit B 1
KCNU1 potassium channel, subfamily U, member 1
KDM3A lysine (K)-specific demethylase 3A
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LDHC lactate dehydrogenase C
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LIPE lipase, hormone-sensitive
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
MAK male germ cell-associated kinase
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MEIG1 meiosis/spermiogenesis associated 1
MNS1 meiosis-specific nuclear structural 1
NEURL1 neuralized E3 ubiquitin protein ligase 1
NPEPPS aminopeptidase puromycin sensitive
NPHP4 nephronophthisis 4
NUP210L nucleoporin 210kDa-like
NXF2 nuclear RNA export factor 2
ODF1 outer dense fiber of sperm tails 1
ODF2 outer dense fiber of sperm tails 2
OPRM1 opioid receptor, mu 1
PCSK4 proprotein convertase subtilisin/kexin type 4
PGK2 phosphoglycerate kinase 2
PICK1 protein interacting with PRKCA 1
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLA2G3 phospholipase A2, group III
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PLTP phospholipid transfer protein
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRND prion protein 2 (dublet)
PRSS21 protease, serine, 21 (testisin)
PSME4 proteasome (prosome, macropain) activator subunit 4
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B)
RABL2A RAB, member of RAS oncogene family-like 2A
ROPN1 rhophilin associated tail protein 1
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase
RXRB retinoid X receptor, beta
SEPT4 septin 4
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SH2B1 SH2B adaptor protein 1
SIRT1 sirtuin 1
SLC26A4 solute carrier family 26 (anion exchanger), member 4
SLC26A8 solute carrier family 26 (anion exchanger), member 8
SLC9C1 solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1
SLIRP SRA stem-loop interacting RNA binding protein
SMCP sperm mitochondria-associated cysteine-rich protein
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SOX8 SRY (sex determining region Y)-box 8
SPACA1 sperm acrosome associated 1
SPAG16 sperm associated antigen 16
SPAG6 sperm associated antigen 6
SPAG9 sperm associated antigen 9
SPEM1 spermatid maturation 1
STRBP spermatid perinuclear RNA binding protein
STYX serine/threonine/tyrosine interacting protein
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa
TALDO1 transaldolase 1
TBC1D20 TBC1 domain family, member 20
TCTE3 t-complex-associated-testis-expressed 3
TEKT2 tektin 2 (testicular)
TEKT3 tektin 3
TEKT4 tektin 4
THEG theg spermatid protein
TMF1 TATA element modulatory factor 1
TNP1 transition protein 1 (during histone to protamine replacement)
TNP2 transition protein 2 (during histone to protamine replacement)
TRIP13 thyroid hormone receptor interactor 13
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TSSK6 testis-specific serine kinase 6
TTLL1 tubulin tyrosine ligase-like family member 1
TTLL5 tubulin tyrosine ligase-like family member 5
UBE2B ubiquitin-conjugating enzyme E2B
VDAC3 voltage-dependent anion channel 3
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae)
ZBTB16 zinc finger and BTB domain containing 16
ZPBP zona pellucida binding protein