asthma; Gene Set

Dataset GAD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A chronic respiratory disease manifested as difficulty breathing due to the narrowing of bronchial passageways.|Tendency of the smooth muscle of the tracheobronchial tree to contract more intensely in response to a given stimulus than it does in the response seen in normal individuals. This condition is present in virtually all symptomatic patients with asthma. The most prominent manifestation of this smooth muscle contraction is a decrease in airway caliber that can be readily measured in the pulmonary function laboratory.|A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).|A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors resulting in recurring periods of wheezing (a whistling sound while breathing), chest tightness, shortness of breath, mucus production and coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, excercise, stress, reflux disease, medications, foods and emotional anxiety. (Experimental Factor Ontology, EFO_0000270)
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Genes

110 genes associated with the disease asthma; in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ACE angiotensin I converting enzyme
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
ADAM33 ADAM metallopeptidase domain 33
ADRB2 adrenoceptor beta 2, surface
BDNF brain-derived neurotrophic factor
C3 complement component 3
CAT catalase
CCL11 chemokine (C-C motif) ligand 11
CCL2 chemokine (C-C motif) ligand 2
CCL24 chemokine (C-C motif) ligand 24
CCL26 chemokine (C-C motif) ligand 26
CCR2 chemokine (C-C motif) receptor 2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD14 CD14 molecule
CD28 CD28 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD86 CD86 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIA chitinase, acidic
CHML choroideremia-like (Rab escort protein 2)
CHRM1 cholinergic receptor, muscarinic 1
CHRM3 cholinergic receptor, muscarinic 3
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTTN cortactin
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYBA cytochrome b-245, alpha polypeptide
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
DPP10 dipeptidyl-peptidase 10 (non-functional)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EPHX2 epoxide hydrolase 2, cytoplasmic
ERO1LB ERO1-like beta (S. cerevisiae)
GC group-specific component (vitamin D binding protein)
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
HAVCR1 hepatitis A virus cellular receptor 1
HAVCR2 hepatitis A virus cellular receptor 2
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLX H2.0-like homeobox
IFNG interferon, gamma
IL10 interleukin 10
IL12A interleukin 12A
IL13 interleukin 13
IL17A interleukin 17A
IL17RB interleukin 17 receptor B
IL18R1 interleukin 18 receptor 1
IL18RAP interleukin 18 receptor accessory protein
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL33R interleukin 33 receptor
IL4 interleukin 4
IL4R interleukin 4 receptor
IL6 interleukin 6
IL6R interleukin 6 receptor
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITLN1 intelectin 1 (galactofuranose binding)
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MS4A2 membrane-spanning 4-domains, subfamily A, member 2
MYLK myosin light chain kinase
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NOS3 nitric oxide synthase 3 (endothelial cell)
NPPA natriuretic peptide A
NPSR1 neuropeptide S receptor 1
NQO1 NAD(P)H dehydrogenase, quinone 1
NRG1 neuregulin 1
OPN3 opsin 3
ORMDL3 ORMDL sphingolipid biosynthesis regulator 3
PARP1 poly (ADP-ribose) polymerase 1
PDE4D phosphodiesterase 4D, cAMP-specific
PHF11 PHD finger protein 11
PON1 paraoxonase 1
PON2 paraoxonase 2
PTGDR prostaglandin D2 receptor (DP)
PTGDR2 prostaglandin D2 receptor 2
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SNW1 SNW domain containing 1
SPINK5 serine peptidase inhibitor, Kazal type 5
STAT2 signal transducer and activator of transcription 2, 113kDa
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TBX21 T-box 21
TIMD4 T-cell immunoglobulin and mucin domain containing 4
TLE4 transducin-like enhancer of split 4
TLR1 toll-like receptor 1
TLR10 toll-like receptor 10
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TLR6 toll-like receptor 6
TLR9 toll-like receptor 9
TNF tumor necrosis factor
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor