asthma Gene Set

Dataset DISEASES Experimental Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description A chronic respiratory disease manifested as difficulty breathing due to the narrowing of bronchial passageways.|Tendency of the smooth muscle of the tracheobronchial tree to contract more intensely in response to a given stimulus than it does in the response seen in normal individuals. This condition is present in virtually all symptomatic patients with asthma. The most prominent manifestation of this smooth muscle contraction is a decrease in airway caliber that can be readily measured in the pulmonary function laboratory.|A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).|A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors resulting in recurring periods of wheezing (a whistling sound while breathing), chest tightness, shortness of breath, mucus production and coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, excercise, stress, reflux disease, medications, foods and emotional anxiety. (Experimental Factor Ontology, EFO_0000270)
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Genes

90 genes associated with the disease asthma in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
ZPBP2 zona pellucida binding protein 2 1.50071
NOTCH4 notch 4 1.49392
IKZF3 IKAROS family zinc finger 3 (Aiolos) 1.47477
PBX2 pre-B-cell leukemia homeobox 2 1.07383
TSLP thymic stromal lymphopoietin 1.02486
CRB1 crumbs family member 1, photoreceptor morphogenesis associated 0.945428
IKZF4 IKAROS family zinc finger 4 (Eos) 0.945428
STAC2 SH3 and cysteine rich domain 2 0.945428
SLC30A8 solute carrier family 30 (zinc transporter), member 8 0.916033
IL33 interleukin 33 0.872896
USP38 ubiquitin specific peptidase 38 0.872896
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 0.842276
TOP2A topoisomerase (DNA) II alpha 170kDa 0.835734
CDK2 cyclin-dependent kinase 2 0.724323
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 0.69843
HNMT histamine N-methyltransferase 0.647573
IL33R interleukin 33 receptor 0.63207
IL18R1 interleukin 18 receptor 1 0.63207
MAGEE1 melanoma antigen family E1 0.602429
NRG1 neuregulin 1 0.602429
HLA-DOA major histocompatibility complex, class II, DO alpha 0.572184
PYHIN1 pyrin and HIN domain family, member 1 0.572184
SMAD3 SMAD family member 3 0.572184
GSDMA gasdermin A 0.561725
IL2RB interleukin 2 receptor, beta 0.52461
ANTXR1 anthrax toxin receptor 1 0.52461
ORMDL3 ORMDL sphingolipid biosynthesis regulator 3 0.52461
C1ORF53 chromosome 1 open reading frame 53 0.52461
IL6R interleukin 6 receptor 0.486425
SUMF1 sulfatase modifying factor 1 0.486425
C11ORF30 chromosome 11 open reading frame 30 0.486425
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.486425
PDE4D phosphodiesterase 4D, cAMP-specific 0.464771
TUSC3 tumor suppressor candidate 3 0.438544
DENND1B DENN/MADD domain containing 1B 0.429338
GAB1 GRB2-associated binding protein 1 0.4215
GSDMB gasdermin B 0.403461
RORA RAR-related orphan receptor A 0.403461
IL13 interleukin 13 0.403461
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 0.368757
RAD50 RAD50 homolog (S. cerevisiae) 0.345945
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit 0.327313
PRKG1 protein kinase, cGMP-dependent, type I 0.311576
SYNE2 spectrin repeat containing, nuclear envelope 2 0.297866
ERO1LB ERO1-like beta (S. cerevisiae) 0.285417
CHCHD2P9 coiled-coil-helix-coiled-coil-helix domain containing 2 pseudogene 9 0.285417
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 0.285417
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.274608
SPATS2L spermatogenesis associated, serine-rich 2-like 0.256228
PCDH15 protocadherin-related 15 0.256228
TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa 0.256228
PLXNA4 plexin A4 0.197766
C5ORF56 chromosome 5 open reading frame 56 0.197766
SCG3 secretogranin III 0.197766
DCLK1 doublecortin-like kinase 1 0.15771
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 0.15771
ZNF28 zinc finger protein 28 0.126165
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.126165
ZNF665 zinc finger protein 665 0.126165
CCDC67 coiled-coil domain containing 67 0.126165
C20ORF85 chromosome 20 open reading frame 85 0.126165
ACO1 aconitase 1, soluble 0.126165
NDFIP1 Nedd4 family interacting protein 1 0.126165
PCDH9 protocadherin 9 0.126165
ZNF644 zinc finger protein 644 0.100789
ANK1 ankyrin 1, erythrocytic 0.100789
DLEU1 deleted in lymphocytic leukemia 1 (non-protein coding) 0.100789
C10ORF54 chromosome 10 open reading frame 54 0.080593
CTNND2 catenin (cadherin-associated protein), delta 2 0.080593
CDH23 cadherin-related 23 0.080593
T T, brachyury homolog (mouse) 0.080593
LCE3C late cornified envelope 3C 0.080593
PDE9A phosphodiesterase 9A 0.080593
RPL10AP3 ribosomal protein L10a pseudogene 3 0.064973
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 0.064973
WDR11 WD repeat domain 11 0.064973
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 0.064973
USP15 ubiquitin specific peptidase 15 0.064973
MPP7 membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7) 0.064973
PRKCE protein kinase C, epsilon 0.064973
MAVS mitochondrial antiviral signaling protein 0.052255
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.043246
CPO carboxypeptidase O 0.043246
CNTLN centlein, centrosomal protein 0.043246
CSMD1 CUB and Sushi multiple domains 1 0.043246
KANK1 KN motif and ankyrin repeat domains 1 0.043246
TRPM8 transient receptor potential cation channel, subfamily M, member 8 0.043246
S100B S100 calcium binding protein B 0.043246
COL22A1 collagen, type XXII, alpha 1 0.043246
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 0.043246