asthma Gene Set

Dataset GAD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has_symptom recurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety. (Human Disease Ontology, DOID_2841)
Similar Terms
Downloads & Tools

Genes

349 genes associated with the disease asthma in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

Symbol Name
AAA1 aortic aneurysm, familial abdominal 1
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
ACE angiotensin I converting enzyme
ACP1 acid phosphatase 1, soluble
ADA adenosine deaminase
ADAM33 ADAM metallopeptidase domain 33
ADCY2 adenylate cyclase 2 (brain)
ADCY9 adenylate cyclase 9
ADGRB3 adhesion G protein-coupled receptor B3
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ADORA1 adenosine A1 receptor
ADRA1B adrenoceptor alpha 1B
ADRB2 adrenoceptor beta 2, surface
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
AICDA activation-induced cytidine deaminase
AKAP6 A kinase (PRKA) anchor protein 6
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALOX5 arachidonate 5-lipoxygenase
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANK1 ankyrin 1, erythrocytic
AOAH acyloxyacyl hydrolase (neutrophil)
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)
ARG1 arginase 1
ARG2 arginase 2
ATP11AUN ATP11A upstream neighbor
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BDKRB2 bradykinin receptor B2
BEST1 bestrophin 1
C10ORF54 chromosome 10 open reading frame 54
C3 complement component 3
C3AR1 complement component 3a receptor 1
C5 complement component 5
C5AR1 complement component 5a receptor 1
C6ORF10 chromosome 6 open reading frame 10
C9ORF135 chromosome 9 open reading frame 135
CACNG6 calcium channel, voltage-dependent, gamma subunit 6
CACUL1 CDK2-associated, cullin domain 1
CAT catalase
CCDC140 coiled-coil domain containing 140
CCDC67 coiled-coil domain containing 67
CCL1 chemokine (C-C motif) ligand 1
CCL11 chemokine (C-C motif) ligand 11
CCL2 chemokine (C-C motif) ligand 2
CCL24 chemokine (C-C motif) ligand 24
CCL26 chemokine (C-C motif) ligand 26
CCL5 chemokine (C-C motif) ligand 5
CCL7 chemokine (C-C motif) ligand 7
CCR3 chemokine (C-C motif) receptor 3
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD14 CD14 molecule
CDH23 cadherin-related 23
CDK2 cyclin-dependent kinase 2
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CGN cingulin
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIA chitinase, acidic
CHIT1 chitinase 1 (chitotriosidase)
CHN2 chimerin 2
CHRM2 cholinergic receptor, muscarinic 2
CHRM3 cholinergic receptor, muscarinic 3
CLCA1 chloride channel accessory 1
CMA1 chymase 1, mast cell
CNOT6L CCR4-NOT transcription complex, subunit 6-like
CNTLN centlein, centrosomal protein
COL26A1 collagen, type XXVI, alpha 1
CPNE4 copine IV
CRB1 crumbs family member 1, photoreceptor morphogenesis associated
CREB1 cAMP responsive element binding protein 1
CREB5 cAMP responsive element binding protein 5
CRHR1 corticotropin releasing hormone receptor 1
CRHR2 corticotropin releasing hormone receptor 2
CRLF2 cytokine receptor-like factor 2
CSF1R colony stimulating factor 1 receptor
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CSMD1 CUB and Sushi multiple domains 1
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTNNA3 catenin (cadherin-associated protein), alpha 3
CTNND2 catenin (cadherin-associated protein), delta 2
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR2 chemokine (C-X-C motif) receptor 2
CXCR3 chemokine (C-X-C motif) receptor 3
CXCR4 chemokine (C-X-C motif) receptor 4
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYSLTR1 cysteinyl leukotriene receptor 1
CYSLTR2 cysteinyl leukotriene receptor 2
DAP3 death associated protein 3
DEFB1 defensin, beta 1
DENND1B DENN/MADD domain containing 1B
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DOCK2 dedicator of cytokinesis 2
DPP10 dipeptidyl-peptidase 10 (non-functional)
DUSP1 dual specificity phosphatase 1
EDN1 endothelin 1
EGR1 early growth response 1
ELAC2 elaC ribonuclease Z 2
ELAVL2 ELAV like neuron-specific RNA binding protein 2
ELF5 E74-like factor 5 (ets domain transcription factor)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ESR1 estrogen receptor 1
EYA2 EYA transcriptional coactivator and phosphatase 2
FAM196B family with sequence similarity 196, member B
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23)
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FKBP4 FK506 binding protein 4, 59kDa
FKBP5 FK506 binding protein 5
FLG filaggrin
FOXP3 forkhead box P3
FSIP1 fibrous sheath interacting protein 1
FSTL4 follistatin-like 4
FUT2 fucosyltransferase 2 (secretor status included)
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
FYN FYN proto-oncogene, Src family tyrosine kinase
G2E3 G2/M-phase specific E3 ubiquitin protein ligase
GAB1 GRB2-associated binding protein 1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GATA3 GATA binding protein 3
GCLM glutamate-cysteine ligase, modifier subunit
GHRL ghrelin/obestatin prepropeptide
GLIS3 GLIS family zinc finger 3
GNAS GNAS complex locus
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
GPX4 glutathione peroxidase 4
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GRM1 glutamate receptor, metabotropic 1
GSDMA gasdermin A
GSDMB gasdermin B
GSTA1 glutathione S-transferase alpha 1
GSTA4 glutathione S-transferase alpha 4
GSTM1 glutathione S-transferase mu 1
GSTM3 glutathione S-transferase mu 3 (brain)
GSTO1 glutathione S-transferase omega 1
GSTO2 glutathione S-transferase omega 2
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
HAVCR1 hepatitis A virus cellular receptor 1
HAVCR2 hepatitis A virus cellular receptor 2
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HLA-B major histocompatibility complex, class I, B
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-G major histocompatibility complex, class I, G
HLX H2.0-like homeobox
HMOX1 heme oxygenase 1
HNMT histamine N-methyltransferase
HP haptoglobin
HS3ST4 heparan sulfate (glucosamine) 3-O-sulfotransferase 4
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA8 heat shock 70kDa protein 8
ICAM1 intercellular adhesion molecule 1
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IGHG3 immunoglobulin heavy constant gamma 3 (G3m marker)
IL10 interleukin 10
IL12A interleukin 12A
IL12B interleukin 12B
IL12RB2 interleukin 12 receptor, beta 2
IL13 interleukin 13
IL13RA1 interleukin 13 receptor, alpha 1
IL15 interleukin 15
IL16 interleukin 16
IL17A interleukin 17A
IL18 interleukin 18
IL18R1 interleukin 18 receptor 1
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RL1 interleukin 1 receptor-like 1
IL1RL2 interleukin 1 receptor-like 2
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL2RA interleukin 2 receptor, alpha
IL2RB interleukin 2 receptor, beta
IL33 interleukin 33
IL4 interleukin 4
IL4R interleukin 4 receptor
IL5RA interleukin 5 receptor, alpha
IL6 interleukin 6
IL6R interleukin 6 receptor
IL9 interleukin 9
IL9R interleukin 9 receptor
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
IRF1 interferon regulatory factor 1
JUND jun D proto-oncogene
KANK1 KN motif and ankyrin repeat domains 1
LAMA1 laminin, alpha 1
LBH limb bud and heart development
LEP leptin
LEPR leptin receptor
LRRC4C leucine rich repeat containing 4C
LTA lymphotoxin alpha
LTA4H leukotriene A4 hydrolase
LTB lymphotoxin beta (TNF superfamily, member 3)
LTC4S leukotriene C4 synthase
LY86 lymphocyte antigen 86
MAPK10 mitogen-activated protein kinase 10
MAVS mitochondrial antiviral signaling protein
MBL2 mannose-binding lectin (protein C) 2, soluble
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MRC1 mannose receptor, C type 1
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MS4A2 membrane-spanning 4-domains, subfamily A, member 2
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTUS2 microtubule associated tumor suppressor candidate 2
MUC7 mucin 7, secreted
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NAV2 neuron navigator 2
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NOD1 nucleotide-binding oligomerization domain containing 1
NOS1 nitric oxide synthase 1 (neuronal)
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH4 notch 4
NPAS3 neuronal PAS domain protein 3
NPPA natriuretic peptide A
NPS neuropeptide S
NPSR1 neuropeptide S receptor 1
NQO1 NAD(P)H dehydrogenase, quinone 1
NR1D1 nuclear receptor subfamily 1, group D, member 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRDE2 NRDE-2, necessary for RNA interference, domain containing
NRG3 neuregulin 3
OR4K13 olfactory receptor, family 4, subfamily K, member 13
ORMDL3 ORMDL sphingolipid biosynthesis regulator 3
PARVB parvin, beta
PAX3 paired box 3
PBX2 pre-B-cell leukemia homeobox 2
PCDH15 protocadherin-related 15
PDE4D phosphodiesterase 4D, cAMP-specific
PDE9A phosphodiesterase 9A
PHF11 PHD finger protein 11
PINX1 PIN2/TERF1 interacting, telomerase inhibitor 1
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PKP1 plakophilin 1
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLXNA4 plexin A4
POLI polymerase (DNA directed) iota
PPARG peroxisome proliferator-activated receptor gamma
PRKCA protein kinase C, alpha
PRKCE protein kinase C, epsilon
PRKG1 protein kinase, cGMP-dependent, type I
PRNP prion protein
PTGDR prostaglandin D2 receptor (DP)
PTGDR2 prostaglandin D2 receptor 2
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGES3 prostaglandin E synthase 3 (cytosolic)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPRD protein tyrosine phosphatase, receptor type, D
PYHIN1 pyrin and HIN domain family, member 1
RAD50 RAD50 homolog (S. cerevisiae)
RNASE3 ribonuclease, RNase A family, 3
RORA RAR-related orphan receptor A
S1PR1 sphingosine-1-phosphate receptor 1
SCG3 secretogranin III
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCGB3A2 secretoglobin, family 3A, member 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP2 secreted frizzled-related protein 2
SFRP5 secreted frizzled-related protein 5
SIGLEC8 sialic acid binding Ig-like lectin 8
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLC30A8 solute carrier family 30 (zinc transporter), member 8
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7
SMAD3 SMAD family member 3
SMAP2 small ArfGAP2
SOCS1 suppressor of cytokine signaling 1
SOD2 superoxide dismutase 2, mitochondrial
SPINK5 serine peptidase inhibitor, Kazal type 5
ST2 suppression of tumorigenicity 2
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT4 signal transducer and activator of transcription 4
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STIP1 stress-induced phosphoprotein 1
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
SYNPR synaptoporin
TAC1 tachykinin, precursor 1
TAC3 tachykinin 3
TAC4 tachykinin 4 (hemokinin)
TACR2 tachykinin receptor 2
TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TBX21 T-box 21
TBXA2R thromboxane A2 receptor
TF transferrin
TGFB1 transforming growth factor, beta 1
TGFB2 transforming growth factor, beta 2
TGFBR1 transforming growth factor, beta receptor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGFBR3 transforming growth factor, beta receptor III
THBS4 thrombospondin 4
TIMP1 TIMP metallopeptidase inhibitor 1
TLR10 toll-like receptor 10
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TLR6 toll-like receptor 6
TLR9 toll-like receptor 9
TMCO4 transmembrane and coiled-coil domains 4
TMEM132D transmembrane protein 132D
TMEM161B transmembrane protein 161B
TMEM62 transmembrane protein 62
TNC tenascin C
TNF tumor necrosis factor
TNIP1 TNFAIP3 interacting protein 1
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
TRA T cell receptor alpha locus
TRB T cell receptor beta locus
TRG T cell receptor gamma locus
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TRPV4 transient receptor potential cation channel, subfamily V, member 4
TSLP thymic stromal lymphopoietin
TUSC3 tumor suppressor candidate 3
UBE3C ubiquitin protein ligase E3C
VEGFA vascular endothelial growth factor A
WIF1 WNT inhibitory factor 1
WISP1 WNT1 inducible signaling pathway protein 1
ZMYND8 zinc finger, MYND-type containing 8
ZNF423 zinc finger protein 423
ZNF585B zinc finger protein 585B