astigmatism Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description Unequal curvature of the refractive surfaces of the eye. Thus a point source of light cannot be brought to a point focus on the retina but is spread over a more or less diffuse area. This results from the radius of curvature in one plane being longer or shorter than the radius at right angles to it. (Dorland, 27th ed). (Experimental Factor Ontology, EFO_0004222)
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Genes

141 genes co-occuring with the disease astigmatism in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
IFITM2 interferon induced transmembrane protein 2 2.56832
DPT dermatopontin 2.34736
GREM2 gremlin 2, DAN family BMP antagonist 1.89221
FLNA filamin A, alpha 1.84045
DDT D-dopachrome tautomerase 1.69587
DSE dermatan sulfate epimerase 1.68725
MATK megakaryocyte-associated tyrosine kinase 1.54407
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 1.20742
GHITM growth hormone inducible transmembrane protein 1.20699
DAND5 DAN domain family member 5, BMP antagonist 1.16478
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit 1.1507
CTSC cathepsin C 1.1473
C19ORF26 chromosome 19 open reading frame 26 1.14348
IRX6 iroquois homeobox 6 1.12066
LCK LCK proto-oncogene, Src family tyrosine kinase 1.11183
IRX3 iroquois homeobox 3 1.03746
SUB1 SUB1 homolog (S. cerevisiae) 1.03325
KIF21A kinesin family member 21A 1.00963
OR2B2 olfactory receptor, family 2, subfamily B, member 2 0.97296
CDK11A cyclin-dependent kinase 11A 0.961634
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic 0.95745
VSX1 visual system homeobox 1 0.922561
TBC1D7 TBC1 domain family, member 7 0.911022
AK3 adenylate kinase 3 0.905265
VAX2 ventral anterior homeobox 2 0.898282
EARS2 glutamyl-tRNA synthetase 2, mitochondrial 0.898282
RPGR retinitis pigmentosa GTPase regulator 0.88475
CORO1A coronin, actin binding protein, 1A 0.865502
SIM2 single-minded family bHLH transcription factor 2 0.843802
ADAMTSL4 ADAMTS-like 4 0.813873
STAP2 signal transducing adaptor family member 2 0.768801
CAND1 cullin-associated and neddylation-dissociated 1 0.768393
NYX nyctalopin 0.728547
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.682294
CROCC ciliary rootlet coiled-coil, rootletin 0.677903
AKAP5 A kinase (PRKA) anchor protein 5 0.668742
SYCP3 synaptonemal complex protein 3 0.667947
BAG4 BCL2-associated athanogene 4 0.666358
ST5 suppression of tumorigenicity 5 0.637102
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1 0.635135
RP2 retinitis pigmentosa 2 (X-linked recessive) 0.630813
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 0.63042
FABP9 fatty acid binding protein 9, testis 0.619051
PER1 period circadian clock 1 0.615529
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 0.613574
POU2F1 POU class 2 homeobox 1 0.610838
MBD5 methyl-CpG binding domain protein 5 0.610057
GALNS galactosamine (N-acetyl)-6-sulfatase 0.604201
PRAMEF20 PRAME family member 20 0.592895
AK2 adenylate kinase 2 0.589779
GK glycerol kinase 0.578106
GRM6 glutamate receptor, metabotropic 6 0.571495
TSPAN12 tetraspanin 12 0.564112
LAMA3 laminin, alpha 3 0.548583
PRSS21 protease, serine, 21 (testisin) 0.53928
CCDC27 coiled-coil domain containing 27 0.532701
KCNK6 potassium channel, two pore domain subfamily K, member 6 0.531541
PHOX2A paired-like homeobox 2a 0.528449
SPAG7 sperm associated antigen 7 0.52343
STIL SCL/TAL1 interrupting locus 0.513802
KRT12 keratin 12, type I 0.513802
SCX scleraxis basic helix-loop-helix transcription factor 0.493122
AATF apoptosis antagonizing transcription factor 0.483985
UST uronyl-2-sulfotransferase 0.480566
FUT2 fucosyltransferase 2 (secretor status included) 0.46655
SPN sialophorin 0.466172
CHST6 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6 0.465416
FBXO7 F-box protein 7 0.461639
CDKN2A cyclin-dependent kinase inhibitor 2A 0.459373
GLIS2 GLIS family zinc finger 2 0.451831
CUTA cutA divalent cation tolerance homolog (E. coli) 0.443923
DCLRE1C DNA cross-link repair 1C 0.436026
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3 0.433397
TBCE tubulin folding cofactor E 0.41727
ZEB1 zinc finger E-box binding homeobox 1 0.416896
HRK harakiri, BCL2 interacting protein 0.416896
MON1A MON1 secretory trafficking family member A 0.416147
TGFBI transforming growth factor, beta-induced, 68kDa 0.415398
TRPS1 trichorhinophalangeal syndrome I 0.40904
C5ORF38 chromosome 5 open reading frame 38 0.406425
KRT6A keratin 6A, type II 0.405305
ALK anaplastic lymphoma receptor tyrosine kinase 0.403811
AK1 adenylate kinase 1 0.390769
SIX2 SIX homeobox 2 0.390397
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 0.382966
FGFR2 fibroblast growth factor receptor 2 0.375179
BLK BLK proto-oncogene, Src family tyrosine kinase 0.374809
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 0.370368
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.365562
FZD4 frizzled class receptor 4 0.332487
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 0.331391
MS4A2 membrane-spanning 4-domains, subfamily A, member 2 0.33066
SRPX2 sushi-repeat containing protein, X-linked 2 0.330295
CYCS cytochrome c, somatic 0.328469
ZNF77 zinc finger protein 77 0.32774
MATN3 matrilin 3 0.326646
FMOD fibromodulin 0.323002
KRT15 keratin 15, type I 0.322273
MRPL49 mitochondrial ribosomal protein L49 0.320817
ZAK sterile alpha motif and leucine zipper containing kinase AZK 0.320817
NRL neural retina leucine zipper 0.319726
PER2 period circadian clock 2 0.31464
LST1 leukocyte specific transcript 1 0.313552
HTN3 histatin 3 0.304142
HSPB8 heat shock 22kDa protein 8 0.300173
ASPH aspartate beta-hydroxylase 0.298011
KLK15 kallikrein-related peptidase 15 0.297651
BBS1 Bardet-Biedl syndrome 1 0.295492
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.289386
NOVA2 neuro-oncological ventral antigen 2 0.280439
OCA2 oculocutaneous albinism II 0.269043
LMX1B LIM homeobox transcription factor 1, beta 0.267267
CHD7 chromodomain helicase DNA binding protein 7 0.264077
SNRPN small nuclear ribonucleoprotein polypeptide N 0.255946
NMT1 N-myristoyltransferase 1 0.255946
MSMB microseminoprotein, beta- 0.251366
ITGB4 integrin, beta 4 0.242245
CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1 0.240847
WIPF2 WAS/WASL interacting protein family, member 2 0.23492
WNK1 WNK lysine deficient protein kinase 1 0.229716
FGFR3 fibroblast growth factor receptor 3 0.225573
TNC tenascin C 0.220424
IL4 interleukin 4 0.209248
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.206913
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 0.198064
ICK intestinal cell (MAK-like) kinase 0.192971
CORT cortistatin 0.190476
LOXL1 lysyl oxidase-like 1 0.189551
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.181798
CYLD cylindromatosis (turban tumor syndrome) 0.180367
EXTL3 exostosin-like glycosyltransferase 3 0.173057
TNFRSF18 tumor necrosis factor receptor superfamily, member 18 0.169812
FN1 fibronectin 1 0.168381
OR10K2 olfactory receptor, family 10, subfamily K, member 2 0.168381
MMP11 matrix metallopeptidase 11 0.166995
OR10T2 olfactory receptor, family 10, subfamily T, member 2 0.164571
TYR tyrosinase 0.163111
EXT1 exostosin glycosyltransferase 1 0.160574
HSPG2 heparan sulfate proteoglycan 2 0.144868
CD59 CD59 molecule, complement regulatory protein 0.143455
CD68 CD68 molecule 0.135078