astrocytoma Gene Set

Dataset GWASdb SNP-Disease Associations
Category disease or phenotype associations
Type disease
Description A glial tumor of the brain or spinal cord showing astrocytic differentiation. It includes the following clinicopathological entities: pilocytic astrocytoma, diffuse astrocytoma, anaplastic astrocytoma, pleomorphic xanthoastrocytoma, subependymal giant cell astrocytoma, and glioblastoma.|Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation (MeSH).|Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082) (Experimental Factor Ontology, EFO_0000272)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/DOID:3069
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Genes

66 genes associated with the disease astrocytoma in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.

Symbol Name Standardized Value
MGMT O-6-methylguanine-DNA methyltransferase 1.42467
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2 0.474846
USP10 ubiquitin specific peptidase 10 0.474846
KAT2B K(lysine) acetyltransferase 2B 0.473391
LINC00189 long intergenic non-protein coding RNA 189 0.472092
DCC DCC netrin 1 receptor 0.470932
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 0.470095
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) 0.469325
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 0.468962
OGFRL1 opioid growth factor receptor-like 1 0.467687
FRMD8 FERM domain containing 8 0.467525
PCSK6 proprotein convertase subtilisin/kexin type 6 0.465705
IQSEC3 IQ motif and Sec7 domain 3 0.464575
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.464398
MAN1B1 mannosidase, alpha, class 1B, member 1 0.462899
SHROOM3 shroom family member 3 0.462611
LOC146513 uncharacterized LOC146513 0.462611
ZMYND15 zinc finger, MYND-type containing 15 0.461947
TTYH1 tweety family member 1 0.460775
LOC100507195 uncharacterized LOC100507195 0.460583
BTNL2 butyrophilin-like 2 0.459072
ALKBH6 alkB, alkylation repair homolog 6 (E. coli) 0.458231
DOCK1 dedicator of cytokinesis 1 0.457555
CLIP3 CAP-GLY domain containing linker protein 3 0.456744
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.456355
SCARB1 scavenger receptor class B, member 1 0.454559
PTPRO protein tyrosine phosphatase, receptor type, O 0.453479
PAQR5 progestin and adipoQ receptor family member V 0.45341
GPA33 glycoprotein A33 (transmembrane) 0.453375
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.452902
AIFM2 apoptosis-inducing factor, mitochondrion-associated, 2 0.452541
SP100 SP100 nuclear antigen 0.452348
GTSF1 gametocyte specific factor 1 0.451391
RNF168 ring finger protein 168, E3 ubiquitin protein ligase 0.451167
FAM13A family with sequence similarity 13, member A 0.450776
DPH6 diphthamine biosynthesis 6 0.450567
MRPL23 mitochondrial ribosomal protein L23 0.449525
FOXP1 forkhead box P1 0.449525
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.44876
PPA2 pyrophosphatase (inorganic) 2 0.446961
DLG2 discs, large homolog 2 (Drosophila) 0.444667
PARK2 parkin RBR E3 ubiquitin protein ligase 0.444449
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 0.444401
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3 0.444282
PITPNM3 PITPNM family member 3 0.444211
DOCK5 dedicator of cytokinesis 5 0.443882
CDH23 cadherin-related 23 0.443583
DGKI diacylglycerol kinase, iota 0.443067
TMEM222 transmembrane protein 222 0.442974
CEP128 centrosomal protein 128kDa 0.442605
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila) 0.441801
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive) 0.441714
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 0.441477
AADACL3 arylacetamide deacetylase-like 3 0.441306
ARID1A AT rich interactive domain 1A (SWI-like) 0.440519
INSC inscuteable homolog (Drosophila) 0.440277
LOXHD1 lipoxygenase homology domains 1 0.439941
MARCH1 membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase 0.439902
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 0.439649
SLIT3 slit homolog 3 (Drosophila) 0.439515
MROH2A maestro heat-like repeat family member 2A 0.439439
RAI1 retinoic acid induced 1 0.439363
MTUS1 microtubule associated tumor suppressor 1 0.439062
ADGRB3 adhesion G protein-coupled receptor B3 0.439043
SASH1 SAM and SH3 domain containing 1 0.438657
ONECUT2 one cut homeobox 2 0.438512